Pancreatic regenerating protein I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes.

abstract：OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...

journal_title：Pancreas

authors： Yasuda T,Ueda T,Takeyama Y,Shinzeki M,Sawa H,Nakajima T,Ajiki T,Fujino Y,Suzuki Y,Kuroda Y

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...

journal_title：Pancreas

authors： Ikemoto T,Noguchi H,Fujita Y,Takita M,Shimoda M,Sugimoto K,Jackson A,Naziruddin B,Shimada M,Levy MF,Matsumoto S

更新日期：2010-10-01 00:00:00

abstract：:Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,El-Metwally T,Moyer MP,Ricordi C,Adrian TE,Batra SK,Pour PM

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...

journal_title：Pancreas

authors： Estrella JS,Ma LT,Milton DR,Yao JC,Wang H,Rashid A,Broaddus RR

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Clinical trials are a prerequisite for evidence-based medicine. Trial representativity by internal and external validities is an assumption for a transfer into the real world. METHODS:A questionnaire addressing several forms of bias was established. Randomized controlled trials for adjuvant treatment of pan...

journal_title：Pancreas

authors： Sorg C,Schmidt J,Büchler MW,Edler L,Märten A

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...

journal_title：Pancreas

authors： Ortega AR,Gómez-Rodríguez R,Romero M,Fernández-Zapardiel S,Céspedes Mdel M,Carrobles JM

更新日期：2011-03-01 00:00:00

abstract：:A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...

journal_title：Pancreas

authors： Pierzynowski SG,Sharma P,Sobczyk J,Garwacki S,Barej W,Weström B

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVES:Patients with chronic pancreatitis are managed by extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones. Stone density on noncontrast computed tomography (NCCT) is used to predict stone composition and fragility, but no report investigating the pancreatic stone density has been documented. We ai...

journal_title：Pancreas

authors： Ohyama H,Mikata R,Ishihara T,Tsuyuguchi T,Sakai Y,Sugiyama H,Yasui S,Ishii K,Itoh S,Nishikawa T,Watanabe Y,Yokosuka O

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：:Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...

journal_title：Pancreas

authors： Asmis T

更新日期：2016-07-01 00:00:00

abstract：:The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...

journal_title：Pancreas

authors： Friess H,Malfertheiner P,Isenmann R,Kühne H,Beger HG,Büchler MW

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...

journal_title：Pancreas

authors： Cizginer S,Turner BG,Bilge AR,Karaca C,Pitman MB,Brugge WR

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:Pancreatic functions were determined in a Ki-ras-induced actin-interacting protein (KRAP)-deficient (-/-) mouse mutant. METHODS:Pancreatic enzyme, protein, and DNA contents were measured, and histological examinations were conducted. The mixture of bile-pancreatic juice was collected, and amylase and bile a...

journal_title：Pancreas

authors： Miyasaka K,Fujimoto T,Kawanami T,Takiguchi S,Jimi A,Funakoshi A,Shirasawa S

更新日期：2011-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...

journal_title：Pancreas

authors： Kiehne K,Herzig KH,Fölsch UR

更新日期：1997-07-01 00:00:00

abstract：:Dogs with chronic pancreatic fistulae were given 0.5 ml of nonimmune rabbit serum or antibody S5, an antibody raised against the C-terminal pancreatic polypeptide (PP) hexapeptide. A 3-h infusion of secretin (125 ng/kg/h) and CCK8 (50 ng/kg/h) was started 30 min after injecting serum. Exogenous BPP (400 pmol/kg/h) was...

journal_title：Pancreas

authors： Fink AS,Gilbert S,Green H,Taylor IL

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...

journal_title：Pancreas

authors： Szepeshazi K,Schally AV,Nagy A,Halmos G

更新日期：2005-10-01 00:00:00

abstract：:Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcin...

journal_title：Pancreas

authors： Yong WH,Southern JF,Pins MR,Warshaw AL,Compton CC,Lewandrowski KB

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...

journal_title：Pancreas

authors： Zhang X,Duan W,Lee WN,Zhang Y,Xiang F,Liu Q,Go VL,Xiao GG

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...

journal_title：Pancreas

authors： Hane Y,Tsuchikawa T,Nakamura T,Hatanaka KC,Saito T,Tanaka K,Nakanishi Y,Asano T,Noji T,Okamura K,Shichinohe T,Yokota I,Hatanaka Y,Hirano S

更新日期：2020-10-01 00:00:00

abstract：:To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...

journal_title：Pancreas

authors： Kamisawa T,Isawa T,Koike M,Tsuruta K,Okamoto A

更新日期：1995-11-01 00:00:00

abstract：:Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...

journal_title：Pancreas

authors： Dunning BE,Ahrén B

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal tr...

journal_title：Pancreas

authors： De Waele E,Wauters E,Ling Z,Bouwens L

更新日期：2014-10-01 00:00:00

abstract：:Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...

journal_title：Pancreas

authors： Berry SM,Fink AS

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP). METHODS:Fifty patients with AP were prospectively enrolled. Erythrocyte sedimentation rate and CRP were measured at admission and every 12 hours for 48 hours aft...

journal_title：Pancreas

authors： Pongprasobchai S,Jianjaroonwong V,Charatcharoenwitthaya P,Komoltri C,Tanwandee T,Leelakusolvong S,Pausawasdi N,Srikureja W,Chainuvati S,Prachayakul V,Manatsathit S,Kachintorn U

更新日期：2010-11-01 00:00:00

abstract：:Opioid growth factor (OGF, [Met5]-enkephalin) is an endogenous peptide that regulates the growth of human pancreatic cancer. To evaluate whether human subjects with pancreatic cancer have alterations in plasma levels of OGF, fasting blood samples were obtained from 15 patients with histologically confirmed pancreatic ...

journal_title：Pancreas

authors： Smith JP,Conter RL,Demers TM,McLaughlin PJ,Zagon IS

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to i...

journal_title：Pancreas

authors： Inatomi O,Bamba S,Nakai Y,Kusumoto K,Kawakami T,Suzuki T,Suzuki A,Endoh B,Ota S,Inoue A,Itokawa Y,Chikugo K,Andoh A,Mizumoto Y,Tanaka K

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo. METHODS:Murine embryonic pancreas at 12.5 days of gestation was dissected and cultured at the air-medium interface. At 1, 3, and 7 days of culture, the characteristics of cultured murine pancre...

journal_title：Pancreas

authors： Ma F,Haumaitre C,Chen F,Han Z

更新日期：2011-10-01 00:00:00

abstract：:Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...

journal_title：Pancreas

authors： Crucitti F,Doglietto GB,Frontera D,Viola G,Morganti AG,Valentini V,Alfonsi G,Trodella L,Cellini N

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00