Pancreatic regenerating protein I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes.


OBJECTIVES:We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance. METHODS:Rats underwent pancreatic duct ligation (PDL) and were followed through 12 months. Aging rats were studied at 12 and 20 months. Intraperitoneal glucose tolerance tests (IPGTTs) were performed, pancreatic reg I, reg I receptor, insulin gene expression, and reg I protein levels were measured. Pancreatic duct ligation and aged animals were treated with exogenous reg I protein and assessed for glucose metabolism. RESULTS:After PDL, chronic atrophic pancreatitis developed, with a progressive loss of acinar cells and pancreatic reg I. During aging, a similar depression of reg I gene expression was also noted. The reg I levels correlated with pancreatic insulin levels. Twelve months after PDL, IPGTT results were abnormal, which were significantly improved by administration of reg I protein. Aged animals demonstrated depressed IPGTT, which marginally improved after reg I administration. Anti-reg antibody administration to young rats depressed IPGTT to elderly levels. CONCLUSIONS:Depletion of the acinar product reg I is associated with the pathogenesis of impaired glucose tolerance of pancreatitis-associated diabetes and aging, and replacement therapy could be useful in these patients. Reg I is an acinar cell product, which affects islet function.






Bluth M,Mueller CM,Pierre J,Callender G,Kandil E,Viterbo D,Fu SL,Sugawara A,Okamoto H,Zenilman ME




Has Abstract


2008-11-01 00:00:00
















  • Immunoneutralization of circulating pancreatic polypeptide and pancreatic secretion.

    abstract::To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...


    pub_type: 杂志文章


    authors: Konturek SJ,Bielański W,Kwiecień N,Konturek J,Czarnobilski K

    更新日期:1987-01-01 00:00:00

  • Early hemodynamic variables and outcome in severe acute pancreatitis: a retrospective single-center cohort study.

    abstract:OBJECTIVES:The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP). METHODS:One hundred fifty-nine consecutive patients with SAP admitted to the intensive care units between January 2005 and December 2008 were incl...


    pub_type: 杂志文章


    authors: Wilkman E,Kaukonen KM,Pettilä V,Kuitunen A,Varpula M

    更新日期:2013-03-01 00:00:00

  • Effects of feeding, fasting, and caerulein treatment on ornithine decarboxylase in rat pancreas.

    abstract::Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...


    pub_type: 杂志文章


    authors: Langlois A,Morisset J

    更新日期:1991-09-01 00:00:00

  • Organic matrix of pancreatic stones associated with nutritional pancreatitis.

    abstract::In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...


    pub_type: 杂志文章


    authors: Montalto G,Multigner L,Sarles H,De Caro A

    更新日期:1988-01-01 00:00:00

  • Enteral feeding without pancreatic stimulation.

    abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...


    pub_type: 杂志文章


    authors: Kaushik N,Pietraszewski M,Holst JJ,O'Keefe SJ

    更新日期:2005-11-01 00:00:00

  • Nicotine ameliorates experimental severe acute pancreatitis via enhancing immunoregulation of CD4+ CD25+ regulatory T cells.

    abstract:OBJECTIVES:Activation of "nicotinic anti-inflammatory pathway" could reduce severity of inflammation and injury induced by acute pancreatitis. However, the role of regulatory T (Treg) cells in this pathway is unclear. METHODS:Severe acute pancreatitis (SAP) was induced in mice through retrograde injection of 50-μL 2% ...


    pub_type: 杂志文章


    authors: Zheng YS,Wu ZS,Zhang LY,Ke L,Li WQ,Li N,Li JS

    更新日期:2015-04-01 00:00:00

  • Treatment for hyperglycemia promotes pancreatic regeneration in rats without CCK-1 receptor gene expression.

    abstract:INTRODUCTION AND AIM:Recent studies have suggested that CCK is not essential for normal pancreatic growth in mice. We examined whether the treatment of hyperglycemia participates in a non-CCK-1-receptor-mediated mechanism of pancreatic regeneration after partial (30%) pancreatectomy (Px) with use of Otsuka Long-Evans T...


    pub_type: 杂志文章


    authors: Yamamoto M,Jia DM,Fukumitsu K,Otsuki M

    更新日期:2003-05-01 00:00:00

  • Mitochondrial transcription factor a worsens the clinical course of patients with pancreatic cancer through inhibition of apoptosis of cancer cells.

    abstract:OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...


    pub_type: 杂志文章


    authors: Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

    更新日期:2014-04-01 00:00:00

  • Hypertriglyceridemia Induced Pancreatitis: Inpatient Management at a Single Pediatric Institution.

    abstract:OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...


    pub_type: 杂志文章


    authors: Ippisch HM,Alfaro-Cruz L,Fei L,Zou Y,Thompson T,Abu-El-Haija M

    更新日期:2020-03-01 00:00:00

  • The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma.

    abstract:OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...


    pub_type: 杂志文章


    authors: Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

    更新日期:2017-05-01 00:00:00

  • Development of immunotherapy for pancreatic cancer.

    abstract::: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...


    pub_type: 杂志文章,评审


    authors: Kawakami Y,Okada T,Akada M

    更新日期:2004-04-01 00:00:00

  • Islet auto transplantation following total pancreatectomy: a long-term assessment of graft function.

    abstract:UNLABELLED:Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. METHODS:: In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant...


    pub_type: 杂志文章


    authors: Webb MA,Illouz SC,Pollard CA,Gregory R,Mayberry JF,Tordoff SG,Bone M,Cordle CJ,Berry DP,Nicholson ML,Musto PP,Dennison AR

    更新日期:2008-10-01 00:00:00

  • Secretion of protein, fluid, and immunoreactive somatostatin in rat pure pancreatic juice: adaptation to chronic cerulein and secretin treatment.

    abstract::These studies were undertaken to assess the effects of chronic administration of cerulein plus secretin, every 8 h for 10 days on fluid, protein, and somatostatin-like immunoreactivity (SLI) outputs in rat pancreatic juice. Pancreatic secretion was studied with conscious, cannulated rats, during infusion of precollect...


    pub_type: 杂志文章


    authors: Sarfati P,Green GM,Morisset J

    更新日期:1988-01-01 00:00:00

  • Long-term function of islets encapsulated in a redesigned alginate microcapsule construct in omentum pouches of immune-competent diabetic rats.

    abstract:OBJECTIVE:Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft. METHODS:Isolated rat islets were encapsulated in an inner core made with 1.5% low-viscos...


    pub_type: 杂志文章


    authors: Pareta R,McQuilling JP,Sittadjody S,Jenkins R,Bowden S,Orlando G,Farney AC,Brey EM,Opara EC

    更新日期:2014-05-01 00:00:00

  • Binge drinking aggravates the outcomes of first-attack severe acute pancreatitis.

    abstract:OBJECTIVES:To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP). METHODS:This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n...


    pub_type: 杂志文章


    authors: Deng L,Xue P,Huang L,Yang X,Wan M,Xia Q

    更新日期:2010-03-01 00:00:00

  • Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.

    abstract:OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...


    pub_type: 杂志文章


    authors: Ueda K,Kawabe K,Lee L,Tachibana Y,Fujimori N,Igarashi H,Oda Y,Jensen RT,Takayanagi R,Ito T

    更新日期:2017-04-01 00:00:00

  • Urinary neutrophil gelatinase-associated lipocalin as an early predictor of disease severity and mortality in acute pancreatitis.

    abstract:OBJECTIVES:In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a usef...


    pub_type: 杂志文章


    authors: Lipinski M,Rydzewska-Rosolowska A,Rydzewski A,Rydzewska G

    更新日期:2015-04-01 00:00:00

  • Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas.

    abstract:OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...


    pub_type: 杂志文章


    authors: Tei E,Mehta S,Tulachan SS,Yew H,Hembree M,Preuett B,Snyder CL,Yamataka A,Miyano T,Gittes GK

    更新日期:2005-08-01 00:00:00

  • Involvement of endogenous cholecystokinin in pancreatic regeneration after cerulein-induced acute pancreatitis.

    abstract::This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...


    pub_type: 杂志文章


    authors: Jurkowska G,Grondin G,Morisset J

    更新日期:1992-01-01 00:00:00

  • Vascular endothelial growth factor and not cyclooxygenase 2 promotes endothelial cell viability in the pancreatic tumor microenvironment.

    abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...


    pub_type: 杂志文章


    authors: Toomey DP,Manahan E,McKeown C,Rogers A,McMillan H,Geary M,Conlon KC,Murphy JF

    更新日期:2010-07-01 00:00:00

  • Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis.

    abstract:OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...


    pub_type: 杂志文章


    authors: Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

    更新日期:2008-01-01 00:00:00

  • Pancreatic fungal infections: a case report and review of the literature.

    abstract::Pancreatic necrosis as a consequence of acute pancreatitis usually implies a poor prognosis. Infection is the most common complication affecting mortality and appears to be increasing. While bacterial infections, particularly with coliforms, account for the majority of cases of infected necrosis, fungal infections are...


    pub_type: 杂志文章,评审


    authors: Robbins EG 2nd,Stollman NH,Bierman P,Grauer L,Barkin JS

    更新日期:1996-04-01 00:00:00

  • The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice.

    abstract:INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...


    pub_type: 杂志文章


    authors: Yang Z,Chen M,Fialkow LB,Ellett JD,Wu R,Nadler JL

    更新日期:2003-05-01 00:00:00

  • Low serum levels of CD44, CD44v6, and neopterin indicate immune dysfunction in chronic pancreatitis.

    abstract:INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...


    pub_type: 杂志文章


    authors: Schlosser W,Gansauge F,Schlosser S,Gansauge S,Beger HG

    更新日期:2001-11-01 00:00:00

  • Regeneration of tubular complex is promoted by a free space.

    abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...


    pub_type: 杂志文章


    authors: Kitamura T,Asanuma N,Inaba M,Otsuki M,Kasayama S,Kouhara H,Kawase I

    更新日期:2005-03-01 00:00:00

  • Endocrine pancreas in the rat model of exocrine pancreatic insufficiency.

    abstract::A new technique to obstruct the pancreatic ducts was developed by injecting zein solution into the common bile duct of the rat. Four weeks after the injection, the fate of the endocrine pancreas was investigated by studying (a) pancreatic content of four pancreatic hormones, (b) histology and immunohistochemistry of t...


    pub_type: 杂志文章


    authors: Tomita T,Rhodes J,Falscroft J,Doull V,Kimmel JR,Pollock HG

    更新日期:1988-01-01 00:00:00

  • Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor.

    abstract::Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...


    pub_type: 杂志文章


    authors: Song M,Zaninovic V,Kim D,Gukovsky I,Gukovskaya A,Kang K,Pandol S

    更新日期:1999-04-01 00:00:00

  • c-met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth.

    abstract::Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...


    pub_type: 杂志文章


    authors: Kiehne K,Herzig KH,Fölsch UR

    更新日期:1997-07-01 00:00:00

  • Bile exclusion from the gut exacerbates acute pancreatitis caused by pancreatic duct obstruction in rats.

    abstract::Acute pancreatic duct obstruction causes hyperamylasemia and mild pancreatic inflammation. We hypothesized that bile exclusion from the gut, which stimulates pancreatic secretion, exacerbates acute pancreatitis caused by pancreatic duct obstruction. Rats were surgically prepared with gastric, duodenal, bile, and pancr...


    pub_type: 杂志文章


    authors: Murayama KM,Drew JB,Yokoo H,Joehl RJ

    更新日期:1991-03-01 00:00:00

  • A systematic review of solid-pseudopapillary neoplasms: are these rare lesions?

    abstract:OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...


    pub_type: 杂志文章,评审


    authors: Law JK,Ahmed A,Singh VK,Akshintala VS,Olson MT,Raman SP,Ali SZ,Fishman EK,Kamel I,Canto MI,Dal Molin M,Moran RA,Khashab MA,Ahuja N,Goggins M,Hruban RH,Wolfgang CL,Lennon AM

    更新日期:2014-04-01 00:00:00