Abstract:
:Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either from defective ability of galanin to inhibit insulin release or from a reduced degree of pancreatic galaninergic innervation. To address these possibilities, we examined the effect of exogenous galanin on immunoreactive insulin (IRI) levels in ob/ob mice and compared the pancreatic content of galaninlike immunoreactivity (GLIR) in ob/ob mice with that in lean littermates. Intravenous administration of synthetic porcine galanin significantly reduced basal IRI levels in ob/ob mice, suggesting that a defect in galanin action is unlikely to account for the hyperinsulinemia in this model. In contrast, reduced pancreatic galaninergic innervation was supported by findings that pancreatic content of GLIR in ob/ob mice was less than 10% of that in age- and sex-matched lean littermates. The reduction of pancreatic GLIR in ob/ob mice appeared organ specific; no such reduction was observed in adrenal GLIR content when comparing obese and lean mice. In addition, the relationship between pancreatic GLIR content and plasma IRI levels was examined in groups of obese and lean mice. It was found in young females, young males, and older mice of mixed sex that there was a significant negative correlation between pancreatic GLIR and plasma IRI in lean mice, whereas no such correlation was observed in obese mice.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pancreasjournal_title
Pancreasauthors
Dunning BE,Ahrén Bdoi
10.1097/00006676-199203000-00016subject
Has Abstractpub_date
1992-01-01 00:00:00pages
233-9issue
2eissn
0885-3177issn
1536-4828journal_volume
7pub_type
杂志文章相关文献
PANCREAS文献大全abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181f74ad7
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001642
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract::Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199801000-00006
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dab19a
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31816618ba
更新日期:2008-08-01 00:00:00
abstract::Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3182236320
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries. The present study examined the effect and cost of GM for AP treatment using the Japanese Diagnosis Procedure Combination database. METHODS:We performed a propensity score anal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31826495a0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00009
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000150
更新日期:2014-08-01 00:00:00
abstract::Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200011000-00006
更新日期:2000-11-01 00:00:00
abstract::: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200404000-00021
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000588
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000166998.04266.88
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000977
更新日期:2018-02-01 00:00:00
abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200308000-00004
更新日期:2003-08-01 00:00:00
abstract::Scanning electron microscopy (SEM) and energy dispersive x-ray fluorescence (EDXRF) have been used in this study to investigate the morphology, nature, and arrangement of major, minor, and trace elements in human pancreatic calculi (PC) obtained from patients with alcoholic and tropical pancreatitis. The present study...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00005
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181bc0f85
更新日期:2010-01-01 00:00:00
abstract::A new technique to obstruct the pancreatic ducts was developed by injecting zein solution into the common bile duct of the rat. Four weeks after the injection, the fate of the endocrine pancreas was investigated by studying (a) pancreatic content of four pancreatic hormones, (b) histology and immunohistochemistry of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198810000-00010
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181e89f74
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000150110.45017.fc
更新日期:2005-03-01 00:00:00
abstract::In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198603000-00002
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Image-guided radiation therapy allows precise tumor targeting using real-time tracking of radiopaque fiducial markers. To enable appropriate tracking, it is recommended to place fiducials with "ideal fiducial geometry" (IFG). Our objectives were to determine the proportion of patients in whom IFG can be achie...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182864559
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000634
更新日期:2016-11-01 00:00:00
abstract::In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199608000-00003
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182a85e1e
更新日期:2014-01-01 00:00:00
abstract::We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199903000-00004
更新日期:1999-03-01 00:00:00
abstract::The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00006
更新日期:1994-01-01 00:00:00