Conversion of human pancreatic acinar cells toward a ductal-mesenchymal phenotype and the role of transforming growth factor β and activin signaling.

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...

journal_title：Pancreas

authors： Jutric Z,Grendar J,Hoen HM,Cho SW,Cassera MA,Newell PH,Hammill CW,Hansen PD,Wolf RF

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:The risk of adverse effects of dipeptidyl peptidase-4 inhibitors on the exocrine pancreas, particularly the high risk of pancreatitis, is controversial. In this study, we examined the exocrine pancreatic function and structure in spontaneously diabetic Goto-Kakizaki (GK) rats treated with a dipeptidyl peptid...

journal_title：Pancreas

authors： Mizukami H,Inaba W,Takahashi K,Kamata K,Tsuboi K,Yagihashi S

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:An impaired host immunity might concur in determining the dismal prognosis of patients with pancreatic cancer (PC). Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival. METHODS:We studied 115 patients with PC, 44 with chroni...

journal_title：Pancreas

authors： Fogar P,Sperti C,Basso D,Sanzari MC,Greco E,Davoli C,Navaglia F,Zambon CF,Pasquali C,Venza E,Pedrazzoli S,Plebani M

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...

journal_title：Pancreas

authors： Philips T,Kusmartseva I,Gerling IC,Campbell-Thompson M,Wasserfall C,Pugliese A,Longmate JA,Schatz DA,Atkinson MA,Kaddis JS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...

journal_title：Pancreas

authors： Schöffel N,Krempel M,Bundschuh M,Bendels MH,Brüggmann D,Groneberg DA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...

journal_title：Pancreas

authors： Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

更新日期：2014-04-01 00:00:00

abstract：:This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

journal_title：Pancreas

authors： Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraducta...

journal_title：Pancreas

authors： Nakazato T,Suzuki Y,Tanaka R,Abe N,Masaki T,Mori T,Ohkura Y,Sugiyama M

更新日期：2018-03-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：:In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...

journal_title：Pancreas

authors： Merisko EM,Farquhar MG,Palade GE

更新日期：1986-01-01 00:00:00

abstract：:The effects of manganese (Mn2+) on phosphorylation activity in the rat pancreas were examined in an in vitro phosphorylation assay and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of endogenous proteins. Several histones were phosphorylated in the presence of pancreatic supernatant obtained ...

journal_title：Pancreas

authors： Brockenbrough JS,Korc M

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the effects of exogenously administered lactate and pyruvate on blood perfusion in endogenous and transplanted islets. METHODS:Anesthetized Wistar-Furth rats were given lactate or pyruvate intravenously, and regional blood perfusion was studied 3 or 30 minutes late...

journal_title：Pancreas

authors： Barbu A,Johansson Å,Bodin B,Källskog Ö,Carlsson PO,Sandberg M,Börjesson JL,Jansson L

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...

journal_title：Pancreas

authors： Lin Y,Kikuchi S,Tamakoshi A,Yagyu K,Obata Y,Kurosawa M,Inaba Y,Kawamura T,Motohashi Y,Ishibashi T,JACC Study Group.

更新日期：2008-07-01 00:00:00

abstract：:The diagnostic value of bile salt-dependent lipase for pancreatic diseases was tested in sera of 187 patients. Of these patients, 76 suffered from pancreatic carcinoma, 43 from nonmalignant liver diseases (cirrhosis and chronic hepatitis), 18 from acute pancreatitis, and 20 from chronic pancreatitis. The remaining sub...

journal_title：Pancreas

authors： Lombardo D,Montalto G,Roudani S,Mas E,Laugier R,Sbarra V,Abouakil N

更新日期：1993-09-01 00:00:00

abstract：:To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...

journal_title：Pancreas

authors： Lee YL,Kwon HY,Park HS,Lee TH,Park HJ

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...

journal_title：Pancreas

authors： Wang X,Li YG,Du Y,Zhu JY,Li Z

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...

journal_title：Pancreas

authors： Aso T,Ohtsuka T,Matsunaga T,Kimura H,Watanabe Y,Tamura K,Ideno N,Osoegawa T,Takahata S,Shindo K,Ushijima Y,Aishima S,Oda Y,Ito T,Mizumoto K,Tanaka M

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....

journal_title：Pancreas

authors： Xu S,Wei S,Guo Y,Cui D,Yao J

更新日期：2018-02-01 00:00:00

abstract：:Cutaneous metastasis of an occult malignancy to the umbilicus has come to be known as a Sister Mary Joseph's nodule (SMJN). More than 400 cases of this well-described clinical presentation of advanced gastrointestinal and gynecologic cancers have been reported. Pancreatic cancer presenting as a SMJN is a rare phenomen...

journal_title：Pancreas

authors： Yendluri V,Centeno B,Springett GM

更新日期：2007-01-01 00:00:00

abstract：:The clinical, diagnostic, and therapeutic aspects of 27 patients with pancreatopleural fistula (PPF) reported in the literature, and two additional patients managed by the authors, form the basis of this report. The diagnosis of PPF is based on the triad of massive pleural effusions, elevated pleural fluid amylase, an...

journal_title：Pancreas

authors： Bedingfield JA,Anderson MC

更新日期：1986-01-01 00:00:00

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...

journal_title：Pancreas

authors： Hsiao JY,Wang CL,Hsia PJ,Hsieh MC,Hsin SC,Lin KD,Shin SJ

更新日期：2007-11-01 00:00:00

abstract：:Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...

journal_title：Pancreas

authors： Yao CZ,Poston GJ,Ishizuka J,Townsend CM Jr,Thompson JC

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...

journal_title：Pancreas

authors： LaBarre NT,Morgan KA,Adams DB,Waljee AK,Coté GA,Elmunzer BJ

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...

journal_title：Pancreas

authors： Marques RG,Fontaine MJ,Rogers J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:Prognostic value of histological subtypes of pancreatic intraductal papillary mucinous neoplasm (IPMN) has been reported to have conflicting results. The authors investigated the clinicopathological characteristics and prognostic significance of the histological subtypes of IPMNs with various degrees of dysp...

journal_title：Pancreas

authors： Kang MJ,Lee KB,Jang JY,Han IW,Kim SW

更新日期：2013-08-01 00:00:00