C-peptide: much more than a byproduct of insulin biosynthesis.

abstract：OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...

journal_title：Pancreas

authors： Satoi S,Toyokawa H,Yanagimoto H,Yamamoto T,Hirooka S,Yui R,Yamaki S,Takahashi K,Matsui Y,Mergental H,Kwon AH

更新日期：2010-03-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：:Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...

journal_title：Pancreas

authors： Berry SM,Fink AS

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...

journal_title：Pancreas

authors： Nishida A,Inatomi O,Fujimoto T,Imaeda H,Tani M,Andoh A

更新日期：2017-04-01 00:00:00

abstract：:Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....

journal_title：Pancreas

authors： Gou S,Yu J,Wang C,Liu T,Cui P,Li X

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...

journal_title：Pancreas

authors： Harada R,Kawamoto H,Fukatsu H,Kato H,Hirao K,Kurihara N,Mizuno O,Ogawa T,Ishida E,Okada H,Yamamoto K,Yamamoto H

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:The present study describes a simple and cost-effective islet isolation procedure. Using this method, allogeneic islets reverse diabetes in cynomolgus monkeys. METHODS:Pancreatic tissue from 11 cynomolgus monkeys were digested, collected, and purified using a simplified method. Islet quantification, purity,...

journal_title：Pancreas

authors： Qi M,Wang Y,Formo K,Marchese E,Wang S,McGarrigle JJ,Bochenek MA,Kinzer K,Vaca P,Davis M,Ahn SJ,Chang K,Bartholomew A,Benedetti E,Oberholzer J

更新日期：2014-03-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Understanding the effect of lymph node metastasis (LNM) on prognosis in pancreatic neuroendocrine neoplasm is helpful for surgery and follow-up. In this study, we investigated the significance of LNM in well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization ...

journal_title：Pancreas

authors： Harimoto N,Hoshino K,Muranushi R,Hagiwara K,Yamanaka T,Ishii N,Tsukagoshi M,Igarashi T,Tanaka H,Watanabe A,Kubo N,Araki K,Hosouchi Y,Suzuki H,Arakawa K,Hirai K,Fukazawa T,Ikota H,Shirabe K

更新日期：2019-08-01 00:00:00

abstract：:The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...

journal_title：Pancreas

authors： Hafkenscheid JC,Hessels M,Kerstens PJ,Lamers CB

更新日期：1989-01-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) binding sites in adult rat exocrine pancreas were studied by autoradiography using slide-mounted frozen tissue sections with mono-iodinated ANF (101-126) as the tracer. Radiolabel was displaced by unlabeled atrial peptide (IC50 = 2 X 10(-11) M). High specific labeling was found in pancr...

journal_title：Pancreas

authors： Chabot JG,Morel G,Kopelman H,Belles-Isles M,Heisler S

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...

journal_title：Pancreas

authors： Majumder S,Gierisch JM,Bastian LA

更新日期：2015-05-01 00:00:00

abstract：:We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both se...

journal_title：Pancreas

authors： Oomi K,Amano M

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...

journal_title：Pancreas

authors： Olesen SS,Graversen C,Bouwense SA,Wilder-Smith OH,van Goor H,Drewes AM

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Recent observations demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in sensory ganglion neurons. Because sensory nerves are implicated in pancreatic inflammatory processes, we studied the colocal...

journal_title：Pancreas

authors： Lázár BA,Jancsó G,Oszlács O,Nagy I,Sántha P

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Exocrine pancreatic secretion contributes to limit pathogenic bacteria-associated diarrhea. Bovine colostrum, used in the treatment of diarrhea, reduces symptoms originating from gut pathogenic bacteria overgrowth. We hypothesized that bovine colostrum may stimulate the exocrine pancreatic secretion. METHOD...

journal_title：Pancreas

authors： Huguet A,Savary G,Bobillier E,Le Huërou-Luron I

更新日期：2009-04-01 00:00:00

abstract：:We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...

journal_title：Pancreas

authors： Yamaguchi Y,Matsumura F,Liang J,Okabe K,Matsuda T,Ohshiro H,Ishihara K,Akizuki E,Yamada S,Ogawa M

更新日期：1999-05-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on ...

journal_title：Pancreas

authors： Pandol SJ,Gukovsky I,Satoh A,Lugea A,Gukovskaya AS

更新日期：2003-11-01 00:00:00

abstract：:The clinical, diagnostic, and therapeutic aspects of 27 patients with pancreatopleural fistula (PPF) reported in the literature, and two additional patients managed by the authors, form the basis of this report. The diagnosis of PPF is based on the triad of massive pleural effusions, elevated pleural fluid amylase, an...

journal_title：Pancreas

authors： Bedingfield JA,Anderson MC

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...

journal_title：Pancreas

authors： Ceroni M,Galindo J,Guerra JF,Salinas J,Martínez J,Jarufe N

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...

journal_title：Pancreas

authors： Ueda K,Kawabe K,Lee L,Tachibana Y,Fujimori N,Igarashi H,Oda Y,Jensen RT,Takayanagi R,Ito T

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is increased in experimental acute pancreatitis. The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis. METHODS:Acute pancreatitis was in...

journal_title：Pancreas

authors： Sandstrom P,Brooke-Smith ME,Thomas AC,Grivell MB,Saccone GT,Toouli J,Svanvik J

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...

journal_title：Pancreas

authors： Xia QS,Ishigaki Y,Zhao X,Shimasaki T,Nakajima H,Nakagawa H,Takegami T,Chen ZH,Motoo Y

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The consumption of green tea is associated with a lower risk of several types of human carcinomas. A number of studies have focused on the possible mechanisms of cancer prevention by tea extracts, especially polyphenols such as epigallocatechin-3-gallate (EGCG). AIMS AND METHODOLOGY:Green tea-derived EGCG...

journal_title：Pancreas

authors： Takada M,Nakamura Y,Koizumi T,Toyama H,Kamigaki T,Suzuki Y,Takeyama Y,Kuroda Y

更新日期：2002-07-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：:In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...

journal_title：Pancreas

authors： Morales A,Cuéllar A,Ramírez J,Vilchis F,Díaz-Sánchez V

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:This study aims to identify the computed tomography (CT) features that may differentiate nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) with lymph node (LN) metastasis from NF-PanNETs without lymph node metastasis. METHODS:We retrospectively analyzed 166 NF-PanNETs in 166 patients who had unde...

journal_title：Pancreas

authors： Choi SH,Kim HJ,Kim SY,Byun JH,Kim KW,Song KB,Kim SC,Kim MH

更新日期：2017-09-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...

journal_title：Pancreas

authors： Kitagawa M,Naruse S,Ishiguro H,Hayakawa T

更新日期：1998-04-01 00:00:00