Computed Tomography Features Predictive of Lymph Node Involvement in Patients With a Nonfunctioning Pancreatic Neuroendocrine Tumor.

abstract：OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...

journal_title：Pancreas

authors： Nishida A,Inatomi O,Fujimoto T,Imaeda H,Tani M,Andoh A

更新日期：2017-04-01 00:00:00

abstract：:The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...

journal_title：Pancreas

authors： Kuroda T,Shiohara E,Haba Y,Kaneko G,Hanazaki K,Kajikawa S,Iida F

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...

journal_title：Pancreas

authors： Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

更新日期：2005-07-01 00:00:00

abstract：:Human pure pancreatic juice (PPJ) and serum were analyzed for free fatty acids (FFAs) to study whether the damage to pancreatic cell membranes in pancreatitis is reflected as abnormal FFAs concentration and composition. Patients consisted of 13 normal controls, 7 patients with acute pancreatitis (AP) in remission, and...

journal_title：Pancreas

authors： Miyake H,Harada H,Ochi K,Oka H,Ishibashi T,Kimura I

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...

journal_title：Pancreas

authors： Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner H

更新日期：2016-07-01 00:00:00

abstract：:The diagnostic value of bile salt-dependent lipase for pancreatic diseases was tested in sera of 187 patients. Of these patients, 76 suffered from pancreatic carcinoma, 43 from nonmalignant liver diseases (cirrhosis and chronic hepatitis), 18 from acute pancreatitis, and 20 from chronic pancreatitis. The remaining sub...

journal_title：Pancreas

authors： Lombardo D,Montalto G,Roudani S,Mas E,Laugier R,Sbarra V,Abouakil N

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to assess the prognostic significance of late parenchymal pancreas necrosis as observed on serial contrast-enhanced computed tomographic (CT) scan. METHODS:Eighty-four patients with acute necrotizing pancreatitis were included. All initial CT scans were examined on complete contr...

journal_title：Pancreas

authors： Wijffels NA,van Walraven LA,Ophof PJ,Hop WC,van der Harst E,Lange JF

更新日期：2007-03-01 00:00:00

abstract：:In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...

journal_title：Pancreas

authors： Slimak GG,Stark HA,Egan JJ,Jensen RT,Gardner JD

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...

journal_title：Pancreas

authors： Ma QS,Zhang XM,Shen CY,Zeng NL,Wu ZS,Pu Y,Wu CY,Zhou LS,Yang ZW,Zhang M,Shao Y

更新日期：2012-07-01 00:00:00

abstract：:We examined whether pancreas grafts preserved by the two-layer method maintained adenine nucleotides pool as substrates for ATP synthesis before reperfusion and had the ability to recover pancreatic tissue perfusion and synthesize ATP promptly after reperfusion. After preservation by the two-layer cold storage method ...

journal_title：Pancreas

authors： Kim Y,Kuroda Y,Tanioka Y,Matsumoto S,Fujita H,Sakai T,Hamano M,Suzuki Y,Ku Y,Saitoh Y

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of A...

journal_title：Pancreas

authors： Neale RE,Youlden DR,Krnjacki L,Kimlin MG,van der Pols JC

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...

journal_title：Pancreas

authors： Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

更新日期：2008-01-01 00:00:00

abstract：:Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...

journal_title：Pancreas

authors： De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:Our aim was to establish and characterize a novel pancreatic ductal adenocarcinoma cell line from a patient in whom the origin of the invasive carcinoma could be traced back to the intraductal papillary mucinous neoplasm (IPMN) precursor lesion. METHODS:The primary patient-derived tumor was propagated in im...

journal_title：Pancreas

authors： Heller A,Angelova AL,Bauer S,Grekova SP,Aprahamian M,Rommelaere J,Volkmar M,Janssen JW,Bauer N,Herr I,Giese T,Gaida MM,Bergmann F,Hackert T,Fritz S,Giese NA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) are at a higher risk of developing post-ERCP pancreatitis than patients undergoing diagnostic ERCP. The aim of this study was to evaluate the effectiveness of somatostatin in preventing post-therapeutic ERCP pancreatitis. ...

journal_title：Pancreas

authors： Lee KT,Lee DH,Yoo BM

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION AND AIMS:Extracellular matrix (ECM) components participate in the process of tissue repair and development of fibrosis in the pancreas. We studied the production kinetics of ECM components and transforming growth factor (TGF)-beta1 and identified their production sites in the pancreas following pancreatiti...

journal_title：Pancreas

authors： Tashiro M,Nakamura H,Taguchi M,Yamaguchi T,Yoshikawa H,Fukumitsu K,Kihara Y,Otsuki M

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides. METHODS:The effects of antisense to miR-21 and miR-221 on cell proliferation, cell cycle arrest, induction of apoptosis, combinat...

journal_title：Pancreas

authors： Park JK,Lee EJ,Esau C,Schmittgen TD

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Adhesion of tumor cells to extracellular matrix (ECM) proteins plays an important role in tumor invasion and metastasis. AIMS:To investigate the expression of integrins in human pancreatic cancer cell lines and its alteration by interleukin (IL)-1alpha to examine the mechanism of adhesion of metastatic hu...

journal_title：Pancreas

authors： Sawai H,Yamamoto M,Okada Y,Sato M,Akamo Y,Takeyama H,Manabe T

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:The transcription factor Stat1 is a member of the family of signal transducers and transcription activators and responds to interferon-γ stimulation. p21 is a p53-responsive gene for cell cycle regulation and mediates Stat1 antitumor activity. The aim of this study was to analyze their expression for predicti...

journal_title：Pancreas

authors： Sun Y,Yang S,Sun N,Chen J

更新日期：2014-05-01 00:00:00

abstract：:Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...

journal_title：Pancreas

authors： Bhat ST,Talkad VD,Pollo DA,Gardner JD

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...

journal_title：Pancreas

authors： Ikemoto T,Noguchi H,Fujita Y,Takita M,Shimoda M,Sugimoto K,Jackson A,Naziruddin B,Shimada M,Levy MF,Matsumoto S

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...

journal_title：Pancreas

authors： Simsek H,Singh M

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a usef...

journal_title：Pancreas

authors： Lipinski M,Rydzewska-Rosolowska A,Rydzewski A,Rydzewska G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...

journal_title：Pancreas

authors： Yeh TS,Ho YP,Chiu CT,Chen TC,Jan YY,Chen MF

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...

journal_title：Pancreas

authors： Negrelli R,Boninsegna E,Avesani G,Zamboni GA,Brozzi L,Frulloni L,Manfredi R,Pozzi Mucelli R

更新日期：2018-10-01 00:00:00

abstract：AIM:To assess the feasibility and usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) for evaluation of pancreatic exocrine function. METHODOLOGY:S-MRCP was performed in 20 patients with mild (n = 8) or severe (n = 12) chronic pancreatitis (according to the grade of exocrine pancreatic...

journal_title：Pancreas

authors： Czakó L,Endes J,Takács T,Boda K,Lonovics J

更新日期：2001-10-01 00:00:00

abstract：INTRODUCTION:Massive bleeding may complicate the course of either acute or chronic pancreatitis. Although the latter is more frequently involved when bleeding occurs in the acute form, a poorer prognosis is to be expected. Abscess, severe inflammation, regional necrosis, and pseudocysts may cause major vessel erosion, ...

journal_title：Pancreas

authors： Flati G,Andrén-Sandberg A,La Pinta M,Porowska B,Carboni M

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:The role of melatonin in human insulin regulation is poorly understood. AIM:To investigate the influence of melatonin supplementation on glucose and insulin levels and on lipid metabolism in blood serum and the liver. METHODOLOGY:The acute melatonin effects on insulin secretion in male Wistar rats were i...

journal_title：Pancreas

authors： Fabiś M,Pruszyńska E,Maćkowiak P

更新日期：2002-08-01 00:00:00