The prophylactic effect of somatostatin on post-therapeutic endoscopic retrograde cholangiopancreatography pancreatitis: a randomized, multicenter controlled trial.


OBJECTIVES:Patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) are at a higher risk of developing post-ERCP pancreatitis than patients undergoing diagnostic ERCP. The aim of this study was to evaluate the effectiveness of somatostatin in preventing post-therapeutic ERCP pancreatitis. METHODS:This placebo-controlled, double-blind, randomized study involved 391 patients in 3 hospitals who required therapeutic ERCP. Patients were assigned to receive either somatostatin or placebo. The incidence of pancreatitis and hyperamylasemia after performing ERCP was compared between the somatostatin and placebo groups. RESULTS:Pancreatitis occurred in statistically significantly fewer ERCP patients who received somatostatin (7/193: 3.6%) than placebo (19/198: 9.6%; P = 0.02). With regard to the individual ERCP procedures, statistically significant reductions in post-ERCP pancreatitis were seen in patients treated with somatostatin who had stoneremoval (P = 0.04) and endoscopic papillary balloon dilation (P= 0.03). The incidence of hyperamylasemia was lower in the somatostatin group (7.8%) than in the placebo group (12.6%), although this difference was not statistically significant (P > 0.05). CONCLUSIONS:A significantly lower incidence of post-ERCP pancreatitis occurred in patients who received somatostatin prophylaxis. This finding suggests that the administration of somatostatin is useful in preventing pancreatitis in patients undergoing therapeutic ERCP.






Lee KT,Lee DH,Yoo BM




Has Abstract


2008-11-01 00:00:00
















  • Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits.

    abstract:OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...


    pub_type: 杂志文章


    authors: Apodaca-Torrez FR,Goldenberg A,Lobo EJ,Farah JF,Triviño T,Montero EF,Schraibman V,Benvenuto RB,Artigiani Neto R

    更新日期:2007-11-01 00:00:00

  • Use of Mammalian Target of Rapamycin Inhibitors for Pancreas Transplant Immunosuppression Is Associated With Improved Allograft Survival and Improved Early Patient Survival.

    abstract:OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...


    pub_type: 杂志文章


    authors: Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

    更新日期:2019-05-01 00:00:00

  • Regeneration of tubular complex is promoted by a free space.

    abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...


    pub_type: 杂志文章


    authors: Kitamura T,Asanuma N,Inaba M,Otsuki M,Kasayama S,Kouhara H,Kawase I

    更新日期:2005-03-01 00:00:00

  • Cholecystokinin stimulates a specific ribosomal S6 kinase in rat pancreatic acini.

    abstract::Stimulation of intact rat pancreatic acini with cholecystokinin (CCK) enhances the phosphorylation of the ribosomal protein S6 in a dose-dependent manner with half maximal stimulation at 40 pM and maximal stimulation at 1 nM CCK octapeptide. Soluble cellular extracts contained S6 kinase activity assayed using purified...


    pub_type: 杂志文章


    authors: Sung CK,Williams JA

    更新日期:1990-11-01 00:00:00

  • Pancreatic enzyme secretion mediated by novel peptide: monitor peptide hypothesis.

    abstract::A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...


    pub_type: 杂志文章


    authors: Iwai K,Fushiki T,Fukuoka S

    更新日期:1988-01-01 00:00:00

  • Personalized Pancreatic Cancer Management: A Systematic Review of How Machine Learning Is Supporting Decision-making.

    abstract::This review critically analyzes how machine learning is being used to support clinical decision-making in the management of potentially resectable pancreatic cancer. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines, electronic searches of MEDLINE, Embase, PubMed, and Coc...


    pub_type: 杂志文章


    authors: Bradley A,van der Meer R,McKay C

    更新日期:2019-05-01 00:00:00

  • Prior History of Pancreatitis Accelerates the Development of Pancreatic Adenocarcinoma.

    abstract:OBJECTIVES:Presentation of pancreatic adenocarcinoma (PC) as acute pancreatitis (AP), association of chronic pancreatitis (CP) with PC, and role of inflammation in PC carcinogenesis are well recognized. We hypothesized that inflammatory changes associated with remote history of AP (≥2 years before PC diagnosis) would r...


    pub_type: 杂志文章


    authors: Phillips AE,Shah N,Borhani AA,Yadav D,Brand RE

    更新日期:2018-11-01 00:00:00

  • An enzyme immunoassay for the determination of lipase in human duodenal fluid.

    abstract::The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...


    pub_type: 杂志文章


    authors: Hafkenscheid JC,Hessels M,Kerstens PJ,Lamers CB

    更新日期:1989-01-01 00:00:00

  • Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis.

    abstract:INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...


    pub_type: 杂志文章


    authors: Eibl G,Forgacs B,Hotz HG,Buhr HJ,Foitzik T

    更新日期:2002-08-01 00:00:00

  • Emerging Evidence for the Clinical Relevance of Pancreatic Cancer Exosomes.

    abstract::The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...


    pub_type: 杂志文章,评审


    authors: Massoumi RL,Hines OJ,Eibl G,King JC

    更新日期:2019-01-01 00:00:00

  • Clinical Utility of Histological and Radiological Evaluations of Tumor Necrosis for Predicting Prognosis in Pancreatic Cancer.

    abstract:OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...


    pub_type: 杂志文章


    authors: Kudo M,Kobayashi T,Gotohda N,Konishi M,Takahashi S,Kobayashi S,Sugimoto M,Okubo S,Martin J,Cabral H,Ishii G,Kojima M

    更新日期:2020-05-01 00:00:00

  • Assessment of the Rate of Decrease in Serum IgG4 Level of Autoimmune Pancreatitis Patients in Response to Initial Steroid Therapy as a Predictor of Subsequent Relapse.

    abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...


    pub_type: 杂志文章


    authors: Shimizu K,Tahara J,Takayama Y,Akao J,Ajihara T,Nagao K,Shiratori K,Tokushige K

    更新日期:2016-10-01 00:00:00

  • Laparoscopic management of severe acute pancreatitis.

    abstract:INTRODUCTION:Severe acute pancreatitis (SAP) remains a serious disease state difficult to manage. Laparoscopic surgery represents a relatively new solution to this problem. This study was aimed to investigate the feasibility of laparoscopic treatment of SAP and the selection of laparoscopic procedures in various stages...


    pub_type: 杂志文章


    authors: Zhou ZG,Zheng YC,Shu Y,Hu WM,Tian BL,Li QS,Zhang ZD

    更新日期:2003-10-01 00:00:00

  • Type 1 and Type 2 Autoimmune Pancreatitis: Distinctive Clinical and Pathological Features, But Are There Any Differences at Magnetic Resonance? Experience From a Referral Center.

    abstract:OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...


    pub_type: 杂志文章


    authors: Negrelli R,Boninsegna E,Avesani G,Zamboni GA,Brozzi L,Frulloni L,Manfredi R,Pozzi Mucelli R

    更新日期:2018-10-01 00:00:00

  • Atrial natriuretic factor and exocrine pancreas: autoradiographic localization of binding sites and ultrastructural evidence for internalization of endogenous ANF.

    abstract::Atrial natriuretic factor (ANF) binding sites in adult rat exocrine pancreas were studied by autoradiography using slide-mounted frozen tissue sections with mono-iodinated ANF (101-126) as the tracer. Radiolabel was displaced by unlabeled atrial peptide (IC50 = 2 X 10(-11) M). High specific labeling was found in pancr...


    pub_type: 杂志文章


    authors: Chabot JG,Morel G,Kopelman H,Belles-Isles M,Heisler S

    更新日期:1987-01-01 00:00:00

  • Disturbances of the Perioperative Microbiome Across Multiple Body Sites in Patients Undergoing Pancreaticoduodenectomy.

    abstract:OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...


    pub_type: 杂志文章


    authors: Rogers MB,Aveson V,Firek B,Yeh A,Brooks B,Brower-Sinning R,Steve J,Banfield JF,Zureikat A,Hogg M,Boone BA,Zeh HJ,Morowitz MJ

    更新日期:2017-02-01 00:00:00

  • Evaluation of Pathologic Response on Overall Survival After Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...


    pub_type: 杂志文章


    authors: Sell NM,Lee GC,Fernández-Del Castillo C,Ferrone CR,Warshaw AL,Hong TS,Blaszkowsky LS,Lillemoe KD,Qadan M

    更新日期:2020-08-01 00:00:00

  • Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways.

    abstract:OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...


    pub_type: 杂志文章


    authors: Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

    更新日期:2010-01-01 00:00:00

  • High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome.

    abstract:OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...


    pub_type: 杂志文章


    authors: Einama T,Kagata Y,Tsuda H,Morita D,Ogata S,Ueda S,Takigawa T,Kawarabayashi N,Fukatsu K,Sugiura Y,Matsubara O,Hatsuse K

    更新日期:2006-05-01 00:00:00

  • Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.

    abstract:OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...


    pub_type: 杂志文章


    authors: Shah P,Singh MH,Yang YX,Metz DC

    更新日期:2013-08-01 00:00:00

  • Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling.

    abstract:OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...


    pub_type: 杂志文章


    authors: Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

    更新日期:2010-08-01 00:00:00

  • Treatment of duct carcinoma of the pancreas with the LH-RH analogue buserelin.

    abstract::Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...


    pub_type: 杂志文章


    authors: Friess H,Büchler M,Krüger M,Beger HG

    更新日期:1992-01-01 00:00:00

  • Diagnostic Strategy for Differentiating Autoimmune Pancreatitis From Pancreatic Cancer: Is an Endoscopic Retrograde Pancreatography Essential?

    abstract::OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...


    pub_type: 杂志文章


    authors: Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

    更新日期:2012-05-01 00:00:00

  • Energy metabolism in mouse pancreas in response to different dosages of a CCK analogue.

    abstract::Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...


    pub_type: 杂志文章


    authors: Lüthen RE,Niederau C,Ferrell LD,Grendell JH

    更新日期:1995-08-01 00:00:00

  • The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

    abstract:OBJECTIVES:The risk of adverse effects of dipeptidyl peptidase-4 inhibitors on the exocrine pancreas, particularly the high risk of pancreatitis, is controversial. In this study, we examined the exocrine pancreatic function and structure in spontaneously diabetic Goto-Kakizaki (GK) rats treated with a dipeptidyl peptid...


    pub_type: 杂志文章


    authors: Mizukami H,Inaba W,Takahashi K,Kamata K,Tsuboi K,Yagihashi S

    更新日期:2013-07-01 00:00:00

  • Homologous orthotopic implantation models of pancreatic ductal cancer in Syrian golden hamsters: which is better for metastasis research--cell implantation or tissue implantation?

    abstract::With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...


    pub_type: 杂志文章


    authors: Morioka CY,Saito S,Ohzawa K,Watanabe A

    更新日期:2000-03-01 00:00:00

  • Magnetic resonance imaging for pancreatic ductal adenocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters.

    abstract:OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...


    pub_type: 杂志文章


    authors: Ma QS,Zhang XM,Shen CY,Zeng NL,Wu ZS,Pu Y,Wu CY,Zhou LS,Yang ZW,Zhang M,Shao Y

    更新日期:2012-07-01 00:00:00

  • Future Directions in the Treatment of Gastrointestinal and Pancreatic Neuroendocrine Tumors.

    abstract::Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...


    pub_type: 杂志文章


    authors: Asmis T

    更新日期:2016-07-01 00:00:00

  • The Insulin Receptor Is Colocalized With the TRPV1 Nociceptive Ion Channel and Neuropeptides in Pancreatic Spinal and Vagal Primary Sensory Neurons.

    abstract:OBJECTIVES:Recent observations demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in sensory ganglion neurons. Because sensory nerves are implicated in pancreatic inflammatory processes, we studied the colocal...


    pub_type: 杂志文章


    authors: Lázár BA,Jancsó G,Oszlács O,Nagy I,Sántha P

    更新日期:2018-01-01 00:00:00

  • Development and Diagnostic Accuracy of a Breath Test for Pancreatic Exocrine Insufficiency in Chronic Pancreatitis.

    abstract:OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...


    pub_type: 杂志文章


    authors: Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

    更新日期:2016-02-01 00:00:00