Abstract:
INTRODUCTION AND AIMS:Extracellular matrix (ECM) components participate in the process of tissue repair and development of fibrosis in the pancreas. We studied the production kinetics of ECM components and transforming growth factor (TGF)-beta1 and identified their production sites in the pancreas following pancreatitis. METHODOLOGY:Pancreatitis was induced in rats by a single intraductal infusion of oleic acid. Gene expression of TGF-betas and ECM components was studied by northern blotting. Pancreatic stellate cell activation was assessed by immunostaining for alpha-smooth muscle actin (alphaSMA) and desmin. RESULTS:Gene expression of TGF-betas and ECM components was increased in association with pancreatic fibrosis after 1-2 weeks and remained higher than the control levels for the ensuing 12 weeks. Both alphaSMA and desmin were strongly immunostained around small vessels and faintly stained in mesenchymal cells and tubular complexes at 1 week. The combination of staining for alphaSMA plus in situ hybridization for procollagen type III mRNA revealed that procollagen type III mRNA was expressed in both alphaSMA-positive and alphaSMA-negative cells in the mesenchyma. CONCLUSIONS:Our findings demonstrate that expression of genes for both TGF-betas and ECM components was increased and that both alphaSMA-positive myofibroblasts and mesenchymal cells are the major sources of ECM components after pancreatitis.
journal_name
Pancreasjournal_title
Pancreasauthors
Tashiro M,Nakamura H,Taguchi M,Yamaguchi T,Yoshikawa H,Fukumitsu K,Kihara Y,Otsuki Mdoi
10.1097/00006676-200303000-00018subject
Has Abstractpub_date
2003-03-01 00:00:00pages
197-204issue
2eissn
0885-3177issn
1536-4828journal_volume
26pub_type
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