Abstract:
OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of Australia and investigating if there is a role of vitamin D-effective ultraviolet radiation (DUVR), which is related to latitude. METHODS:Mortality data from 1968 to 2005 were sourced from the Australian General Record of Incidence and Mortality books. Negative binomial models were fitted to calculate the association between state and PaCa mortality. Clear sky monthly DUVR in each capital city was also modeled. RESULTS:Mortality from PaCa was 10% higher in southern states than in Queensland, with those in Victoria recording the highest mortality risk (relative risk, 1.13; 95% confidence interval, 1.09-1.17). We found a highly significant association between DUVR and PaCa mortality, with an estimated 1.5% decrease in the risk per 10-kJ/m increase in yearly DUVR. CONCLUSIONS:These data show an association between latitude, DUVR, and PaCa mortality. Although this study cannot be used to infer causality, it supports the need for further investigations of a possible role of vitamin D in PaCa etiology.
journal_name
Pancreasjournal_title
Pancreasauthors
Neale RE,Youlden DR,Krnjacki L,Kimlin MG,van der Pols JCdoi
10.1097/MPA.0b013e31819975f4subject
Has Abstractpub_date
2009-05-01 00:00:00pages
387-90issue
4eissn
0885-3177issn
1536-4828journal_volume
38pub_type
杂志文章相关文献
PANCREAS文献大全abstract::beta-1,4-Galactosyltransferase (GalTase) is the glycosyltransferase in the Golgi apparatus that transfers galactose from UDP-galactose to terminal N-acetylglucosamine residues in glycoconjugates with formation of a beta-1,4 linkage. Neoplasms undergo various changes in the carbohydrate moieties of their glycoconjugate...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199908000-00006
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bb8da1
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000726
更新日期:2017-02-01 00:00:00
abstract::To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199005000-00013
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000835
更新日期:2017-07-01 00:00:00
abstract::In a previous retrospective case-control study, hemoconcentration was associated with the development of pancreatic necrosis. The aim of the present study was to determine in a cohort study whether hemoconcentration is a marker for both organ failure and necrotizing pancreatitis. A cohort study was performed on patien...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200005000-00005
更新日期:2000-05-01 00:00:00
abstract::These studies were undertaken to assess the effects of chronic administration of cerulein plus secretin, every 8 h for 10 days on fluid, protein, and somatostatin-like immunoreactivity (SLI) outputs in rat pancreatic juice. Pancreatic secretion was studied with conscious, cannulated rats, during infusion of precollect...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198808000-00002
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000221617.89376.38
更新日期:2006-05-01 00:00:00
abstract::Pancreatic duct fragments were isolated from rat and hamster pancreas and were cultured in an agarose matrix for up to 8 weeks (rat) or 20 weeks (hamster). The fragments consisted predominantly of duct epithelium, lesser numbers of stromal and atrophied acinar cells, and small numbers of islet cells. Hamster ducts ave...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198707000-00010
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Survivin, an antiapoptotic gene inhibited by p53, is overexpressed in human cancers and correlates with chemotherapy resistance. Here, we investigated the mutual regulatory mechanism between MGMT (O-methylguanine DNA methyltransferase) and survivin. METHODS:This study used standard techniques for protein an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000299
更新日期:2015-05-01 00:00:00
abstract::Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182554276
更新日期:2013-01-01 00:00:00
abstract::We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199905000-00005
更新日期:1999-05-01 00:00:00
abstract::The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000202937.55460.0c
更新日期:2006-03-01 00:00:00
abstract::The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervation was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholinesterase (AChE) activity and the induced fluor...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00013
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd672c
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is the main diagnostic modality for pancreatic mass lesions. However, cytology is often indeterminate, leading to repeat FNAs and delay in care. Here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (FISH) ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182200201
更新日期:2011-10-01 00:00:00
abstract::: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200404000-00021
更新日期:2004-04-01 00:00:00
abstract::The aim of this study was to determine the relationship between pancreatic necrosis and organ failure in acute pancreatitis. Two hundred seventeen patients with acute pancreatitis were prospectively included. All of them had been examined by computed tomography (CT) within 72 hours of admission. Initial organ failure ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200004000-00015
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318201654a
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd6470
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001496
更新日期:2020-03-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is synthesized in islet B cells and stored in the secretory granules. We examined whether IAPP and insulin are released in parallel in humans. Arginine hydrochloride (5 g) was injected intravenously at three glucose levels in 11 healthy 58-year-old female subjects. In the fasting state...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199508000-00015
更新日期:1995-08-01 00:00:00
abstract::A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-198802000-00020
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001707
更新日期:2021-01-01 00:00:00
abstract::The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00035
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000765
更新日期:2017-04-01 00:00:00
abstract::Reports of a so-called "mucin-producing tumor of the pancreas" are increasing worldwide. Although the clinicopathologic features and therapeutic strategies of this tumor have been enthusiastically investigated, there are still many unanswered questions regarding this ailment. In this study, problems in the diagnosis a...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00025
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/01.mpa.0000202952.10612.21
更新日期:2006-04-01 00:00:00
abstract::The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199003000-00003
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d3645b
更新日期:2010-08-01 00:00:00