Platelet-activating factor antagonist (TCV-309) attenuates the priming effects of bronchoalveolar macrophages in cerulein-induced pancreatitis rats.

abstract：:Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemos...

journal_title：Pancreas

authors： Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DP

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...

journal_title：Pancreas

authors： El-Ghamari M,Bergmann F,Schmied BM,Weitz J,Ulrich A

更新日期：2011-03-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity w...

journal_title：Pancreas

authors： Ishiwata T,Bergmann U,Kornmann M,Lopez M,Beger HG,Korc M

更新日期：1997-11-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：:Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...

journal_title：Pancreas

authors： Crucitti F,Doglietto GB,Frontera D,Viola G,Morganti AG,Valentini V,Alfonsi G,Trodella L,Cellini N

更新日期：1998-01-01 00:00:00

abstract：:Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in beta-cell dysfunction, we investigated the impact of the PON1 polymorphisms on beta-cell function. This study included 84 healthy...

journal_title：Pancreas

authors： Chiu KC,Chuang LM,Chu A,Lu J,Hu J,Fernando S

更新日期：2004-05-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...

journal_title：Pancreas

authors： Ceroni M,Galindo J,Guerra JF,Salinas J,Martínez J,Jarufe N

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...

journal_title：Pancreas

authors： Tei E,Mehta S,Tulachan SS,Yew H,Hembree M,Preuett B,Snyder CL,Yamataka A,Miyano T,Gittes GK

更新日期：2005-08-01 00:00:00

abstract：:: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...

journal_title：Pancreas

authors： Kawakami Y,Okada T,Akada M

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...

journal_title：Pancreas

authors： Jia DM,Otsuki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Pancreatic stellate cells (PSCs) play a crucial role during pancreatic fibrosis development. Hydrogen sulfide (H2S) is a recently discovered gaseous transmitter, whose role in PSCs has not been explored yet. In the present study, we examined the effects of sodium hydrosulfide (NaHS), an H2S donor, on rat PSC...

journal_title：Pancreas

authors： Schwer CI,Stoll P,Goebel U,Buerkle H,Hoetzel A,Schmidt R

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis is the consequence of multiple episodes of recurrent acute pancreatitis (RAP). We hypothesized that apigenin can minimize the sequelae of RAP by limiting acinar cells' proinflammatory signaling pathways. METHODS:AR42J acinar cells were treated in vitro with transforming growth factor β (...

journal_title：Pancreas

authors： Mrazek AA,Bhatia V,Falzon M,Spratt H,Chao C,Hellmich MR

更新日期：2019-05-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：:In 134 consecutive patients with acute abdominal pain, we evaluated the clinical role of a new rapid test for serum lipase based on latex agglutination. The results were compared with those obtained with a widely used lipase immunoassay as well as with serum amylase and pancreatic isoamylase measurements. Fifty-five h...

journal_title：Pancreas

authors： Ventrucci M,Pezzilli R,Naldoni P,Montone L,Gullo L

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS:Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study....

journal_title：Pancreas

authors： Joo KR,Shin HP,Cha JM,Nam S,Huh Y

更新日期：2009-08-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Adhesion of tumor cells to extracellular matrix (ECM) proteins plays an important role in tumor invasion and metastasis. AIMS:To investigate the expression of integrins in human pancreatic cancer cell lines and its alteration by interleukin (IL)-1alpha to examine the mechanism of adhesion of metastatic hu...

journal_title：Pancreas

authors： Sawai H,Yamamoto M,Okada Y,Sato M,Akamo Y,Takeyama H,Manabe T

更新日期：2001-11-01 00:00:00

abstract：:Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...

journal_title：Pancreas

authors： Andersson R,Wang X,Sun Z,Deng X,Soltesz V,Ihse I

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:Pancreatoduodenectomy is feasible also in patients with locally advanced pancreatic adenocarcinoma (PA) nowadays. Data on risk and survival analysis of palliative pancreatic resections followed by gemcitabine-based chemotherapy (Cx) are limited. METHODS:Between 2000 and 2009, a total of 45 patients had prim...

journal_title：Pancreas

authors： Bahra M,Pratschke J,Klein F,Neuhaus P,Boas-Knoop S,Puhl G,Denecke T,Pullankavumkal JR,Sinn M,Riess H,Pelzer U

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:To provide histologic correlation of endoscopic ultrasound (EUS) findings believed to represent chronic pancreatitis (CP). METHODS:Eighteen postmortem pancreatic specimens in patients dying of all causes were examined in vitro by EUS for features of CP: (1) echogenic foci, (2) hypoechoic foci, (3) echogenic...

journal_title：Pancreas

authors： Bhutani MS,Arantes VN,Verma D,Moezzi J,Suryaprasad S,Kapadia AS,Gopalswamy N

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...

journal_title：Pancreas

authors： Mayumi T,Inui K,Maetani I,Yokoe M,Sakamoto T,Yoshida M,Ko S,Hirata K,Takada T,Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group).

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...

journal_title：Pancreas

authors： Khan D,Abureesh M,Alkhayyat M,Sadiq W,Alshami M,Munir AB,Karam B,Deeb L,Lafferty J

更新日期：2021-01-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：:This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

journal_title：Pancreas

authors： Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

更新日期：1990-03-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00