Abstract:
:The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity was present in the cytoplasm of islet cells, and mild cytoplasmic immunoreactivity was evident occasionally in ductal and acinar cells. Some ductal cells also exhibited nuclear IGF-IIR immunoreactivity. In the pancreatic cancers, regions of strong IGF-IIR immunoreactivity were present in the duct-like cancer cells within the tumor mass, often exhibiting nuclear localization. Expression of IGF-IIR mRNA in the cancer cells was confirmed by in situ hybridization. By comparison with normal pancreatic tissues, 7 of 12 pancreatic cancers exhibited a 5.6-fold increase in IGF-IIR mRNA levels, whereas in 3 cancers the IGF-IIR transcript was below the level of detection. Furthermore, all six tested cultured human pancreatic cancer cell lines expressed the IGF-IIR mRNA transcript. Our data indicate that IGF-IIR is overexpressed in a significant number of human pancreatic cancers, where it has a tendency to localize in the nucleus, and raise the possibility that IGF-IIR may contribute to the pathobiology of pancreatic cancer.
journal_name
Pancreasjournal_title
Pancreasauthors
Ishiwata T,Bergmann U,Kornmann M,Lopez M,Beger HG,Korc Mdoi
10.1097/00006676-199711000-00006subject
Has Abstractpub_date
1997-11-01 00:00:00pages
367-73issue
4eissn
0885-3177issn
1536-4828journal_volume
15pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000726
更新日期:2017-02-01 00:00:00
abstract::Stimulation of the exocrine pancreas is one of the biological effects attributed to the tridecapeptide neurotensin (NT). Only the C-terminal 8-13 fragment with its extremely short plasma half-life in the peripheral circulation was considered to be necessary for biological activity. The N-terminal fragments that are de...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00018
更新日期:1989-01-01 00:00:00
abstract::A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199001000-00016
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance. METHODS:Rats underwent pancreatic duct ligation (PDL) and were followed through 12 months. Aging rats were studied at 12 and...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31817f7893
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001123
更新日期:2018-09-01 00:00:00
abstract:UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181f95104
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000001071
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess the oxidative stress markers and antioxidant defense system in patients with CP and those with PC. METHODS:Activities of superoxide dismutase 1 (SOD1), catalase (CAT)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318288360a
更新日期:2013-05-01 00:00:00
abstract::Several studies have shown that pituitary adenylate cyclase activating polypeptide (PACAP) stimulates at very low concentration insulin release from pancreatic beta cells. In addition, PACAP has been evidenced in pancreatic nervous fibers surrounding the islets, the core of the islet, and the capillaries. The aim of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200107000-00010
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001496
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31816618ba
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153615.55761.00
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000271
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31805d0190
更新日期:2007-10-01 00:00:00
abstract::To study the influence of extracellular matrix (ECM) on isolated fetal porcine islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel (MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix for 20 days. The insulin accumulation in the culture medium was determined every fifth...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200103000-00008
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181baac47
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to assess the prognostic significance of late parenchymal pancreas necrosis as observed on serial contrast-enhanced computed tomographic (CT) scan. METHODS:Eighty-four patients with acute necrotizing pancreatitis were included. All initial CT scans were examined on complete contr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31802e01ec
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001382
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31812e9688
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c314b3
更新日期:2010-07-01 00:00:00
abstract::Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199105000-00014
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000160301.59319.ba
更新日期:2005-05-01 00:00:00
abstract::Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199707000-00005
更新日期:1997-07-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract::Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leu...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200101000-00001
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirme...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00054
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000861
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001539
更新日期:2020-05-01 00:00:00
abstract::Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199708000-00007
更新日期:1997-08-01 00:00:00
abstract:INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200307000-00002
更新日期:2003-07-01 00:00:00