Abstract:
PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirmed. The results obtained for HLA frequencies were compared with those of 105 healthy control subjects (control group). RESULTS:Increased frequencies of HLA-A30 (16.7 vs. 3.8%; P < 0.01; OR = 5.05), A31 (9.5 vs. 1.9%; P < 0.05; OR = 5.72), B18 (31.7 vs. 14.3%; P < 0.05; OR = 2.78) and Cw7 (53.3 vs. 21.9%; P < 0.01; OR = 4.07) were observed in patients with pancreatic cancer in comparison to the control subjects. CONCLUSIONS:This study demonstrates the association between specific HLA antigens and pancreatic cancer development in whites and suggests a genetic susceptibility factor for the disease.
journal_name
Pancreasjournal_title
Pancreasauthors
Kouerinis IA,Zografos G,Tarassi KE,Athanasiades TH,Liontos M,Gorgoulis VG,Korkolis D,Konstandoulakis MM,Fotiadis CI,Androulakis G,Papasteriades CAdoi
10.1097/00006676-200407000-00054subject
Has Abstractpub_date
2004-07-01 00:00:00pages
41-4issue
1eissn
0885-3177issn
1536-4828pii
00006676-200407000-00054journal_volume
29pub_type
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