Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis.

Abstract:

OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically suspected chronic pancreatitis and 21 healthy volunteers were evaluated. All subjects underwent MRI/MRCP and fecal elastase 1 testing within 1 to 4 weeks' interval. Magnetic resonance cholangiopancreatography images were evaluated according to Cambridge classification. Magnetic resonance imaging of the pancreas was assessed for pancreatic size, signal, and arterial enhancement. RESULTS:All volunteers had normal fecal elastase 1 levels (>200 microg/g) and normal MRI/MRCP findings. Thirty-one of 56 patients revealed MRI and/or MRCP findings despite normal fecal elastase 1 concentration. Four of 25 patients revealed normal MRI and MRCP findings despite low fecal elastase 1 concentration (<200 microg/g). Magnetic resonance imaging findings of size (P = 0.00001), arterial enhancement (P = 0.00001), and parenchymal signal (P = 0.001) were significantly different among the control group, patients with normal fecal elastase 1 levels, and patients with low fecal elastase 1 levels. Magnetic resonance cholangiopancreatography findings (P = 0.00001), pancreatic size (P = 0.00001), arterial enhancement (P = 0.014), and parenchymal signal (P = 0.004) on MRI correlated with the fecal elastase 1 concentration. CONCLUSIONS:Magnetic resonance imaging/MRCP findings correlate with fecal elastase 1 concentration and may precede pancreatic exocrine insufficiency in the early stages of chronic pancreatitis.

journal_name

Pancreas

journal_title

Pancreas

authors

Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

doi

10.1097/mpa.0b013e318150e557

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

e33-9

issue

1

eissn

0885-3177

issn

1536-4828

pii

00006676-200801000-00026

journal_volume

36

pub_type

杂志文章

相关文献

PANCREAS文献大全
  • Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.

    abstract:OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3182847b2e

    authors: Shah P,Singh MH,Yang YX,Metz DC

    更新日期:2013-08-01 00:00:00

  • Comparison of murine embryonic pancreatic development in vitro and in vivo.

    abstract:OBJECTIVES:The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo. METHODS:Murine embryonic pancreas at 12.5 days of gestation was dissected and cultured at the air-medium interface. At 1, 3, and 7 days of culture, the characteristics of cultured murine pancre...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e31821ad758

    authors: Ma F,Haumaitre C,Chen F,Han Z

    更新日期:2011-10-01 00:00:00

  • Effects of leucine on insulin secretion and beta cell membrane potential in mouse islets of Langerhans.

    abstract::Leucine is known to enhance insulin secretion from islets of Langerhans, and insulin promotes leucine uptake in peripheral tissues. The present studies were designed to elucidate the effects of leucine on glucose responsiveness and stimulus secretion coupling in mouse islets of Langerhans. The effects of 20 mM leucine...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199103000-00015

    authors: Brouwer AE,Carroll PB,Atwater IJ

    更新日期:1991-03-01 00:00:00

  • The effects of profound hypothermia on pancreas ischemic injury: a new experimental model.

    abstract:OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000150

    authors: Rocha-Santos V,Ferro OC,Pantanali CA,Seixas MP,Pecora RA,Pinheiro RS,Claro LC,Abdo EE,Chaib E,D'Albuquerque LA

    更新日期:2014-08-01 00:00:00

  • Functional response of a limited beta-cell mass to long-term hyperglycemia.

    abstract::250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199403000-00008

    authors: Dunger A,Kauert C,Brömme HJ,Hildebrandt W,Blech W,Hahn HJ

    更新日期:1994-03-01 00:00:00

  • A case of primary non-Hodgkin lymphoma of the pancreas.

    abstract::Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199201000-00017

    authors: Joly I,David A,Payan MJ,Sahel J,Sarles H

    更新日期:1992-01-01 00:00:00

  • Intestinal disaccharidase activity following pancreatic duct occlusion in the rat.

    abstract::The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four s...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-198705000-00008

    authors: Hauer-Jensen M,Christensen K,Wilson HD,Schedl HP

    更新日期:1987-01-01 00:00:00

  • Reduction of immunogenicity by cyclophosphamide pretreatment and culture on xenograft survival of monkey pancreatic islets transplanted into rats.

    abstract:INTRODUCTION:Islet cell transplantation offers a new approach for the treatment of diabetes. Before transplantation, immunomodulation procedures are conducted to reduce the immunogenicity of the pancreatic islets. AIM:To study the effect of cyclophosphamide pretreatment and culture on the xenograft survival of monkey ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-200204000-00005

    authors: Mythili MD,Ramakrishna B,Gunasekaran S

    更新日期:2002-04-01 00:00:00

  • Venous bypass grafting for celiac occlusion in radical pancreaticoduodenectomy.

    abstract::Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199105000-00014

    authors: Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

    更新日期:1991-05-01 00:00:00

  • Pancreatic antioxidant enzyme activity in normoglycemic diabetic prone BB rats.

    abstract::Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199501000-00007

    authors: Roza AM,Pieper GM,Johnson CP,Adams MB

    更新日期:1995-01-01 00:00:00

  • The expression of chemokine genes correlates with nuclear factor-kappaB activation in human pancreatic cancer cell lines.

    abstract::Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-200007000-00049

    authors: Takaya H,Andoh A,Shimada M,Hata K,Fujiyama Y,Bamba T

    更新日期:2000-07-01 00:00:00

  • Resolution of human exocrine pancreatic juice proteins by reversed-phase high performance liquid chromatography (HPLC).

    abstract::Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199005000-00004

    authors: Göke B,Keim V,Dagorn JC,Arnold R,Adler G

    更新日期:1990-05-01 00:00:00

  • Improved recovery of cryopreserved canine islets by use of beraprost sodium.

    abstract::Cryopreservation of pancreatic islets provides many advantages for clinical transplantation. Unfortunately, the freezing and thawing processes lead to a significant loss of islets. In this study, an attempt was made to increase the yield and viability of islets after cryopreservation and thawing. By using canine islet...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199910000-00010

    authors: Arita S,Kasraie A,Une S,Ohtsuka S,Kawahara T,Smith CV,Mullen Y

    更新日期:1999-10-01 00:00:00

  • Impact of Antibiotic-Resistant Bacterial and Fungal Infections in Outcome of Acute Pancreatitis.

    abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000001019

    authors: Moka P,Goswami P,Kapil A,Xess I,Sreenivas V,Saraya A

    更新日期:2018-04-01 00:00:00

  • Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved in Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins among various stages of pancreatic ductal adenocarcinoma (PDAC) by shotgun proteomics using nano-liquid chromatography coupled tandem mass spectrometry and stable isotope dimethyl labeling. METHODS:Differentially expressed proteins were...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000388

    authors: Kuo KK,Kuo CJ,Chiu CY,Liang SS,Huang CH,Chi SW,Tsai KB,Chen CY,Hsi E,Cheng KH,Chiou SH

    更新日期:2016-01-01 00:00:00

  • Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12-14, 2018, Shanghai, China.

    abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000001482

    authors: Xiao GG,Zhang Z,Lu B,Wang H,Fan TW,Boros LG,Gao P,Pan Y,Go VLW

    更新日期:2020-02-01 00:00:00

  • Nonprevention of post-endoscopic retrograde cholangiopancreatographic pancreatitis by pancreatic stent after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms of the pancreas.

    abstract:OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3181bb8da1

    authors: Harada R,Kawamoto H,Fukatsu H,Kato H,Hirao K,Kurihara N,Mizuno O,Ogawa T,Ishida E,Okada H,Yamamoto K,Yamamoto H

    更新日期:2010-04-01 00:00:00

  • Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?

    abstract:OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...

    journal_title:Pancreas

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPA.0000000000000475

    authors: Olesen SS,Graversen C,Bouwense SA,Wilder-Smith OH,van Goor H,Drewes AM

    更新日期:2016-03-01 00:00:00

  • SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma.

    abstract:OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e318247d6af

    authors: Singh P,Srinivasan R,Wig JD

    更新日期:2012-05-01 00:00:00

  • Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.

    abstract:INTRODUCTION:The consumption of green tea is associated with a lower risk of several types of human carcinomas. A number of studies have focused on the possible mechanisms of cancer prevention by tea extracts, especially polyphenols such as epigallocatechin-3-gallate (EGCG). AIMS AND METHODOLOGY:Green tea-derived EGCG...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-200207000-00012

    authors: Takada M,Nakamura Y,Koizumi T,Toyama H,Kamigaki T,Suzuki Y,Takeyama Y,Kuroda Y

    更新日期:2002-07-01 00:00:00

  • The clinical results of duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy in consecutive 55 cases.

    abstract:OBJECTIVES:Pancreatic anastomotic leakage remains a major troublesome complication after pancreaticoduodenectomy. Thus, various technical modifications regarding the pancreatic anastomosis after pancreaticoduodenectomy have been attempted to minimize anastomotic leakage. We have performed duct-to-mucosa pancreaticojeju...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3180676dc2

    authors: Hayashibe A,Kameyama M

    更新日期:2007-10-01 00:00:00

  • Decreased serum leptin concentration in patients with chronic pancreatitis.

    abstract:OBJECTIVE:Previously reported data suggest that serum leptin concentration changes in some acute and chronic inflammatory diseases. The aim of the present study was to assess serum leptin concentration in patients with chronic pancreatitis. METHODS:Forty-four male patients with chronic pancreatitis and 16 healthy (mal...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/mpa.0b013e3180332e62

    authors: Adrych K,Smoczynski M,Goyke E,Stelmanska E,Swierczynski J

    更新日期:2007-05-01 00:00:00

  • Predictive Effect of the Total Number of Examined Lymph Nodes on N Staging and Survival in Pancreatic Neuroendocrine Neoplasms.

    abstract:OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000987

    authors: Zhang X,Lu L,Liu P,Cao F,Wei Y,Ma L,Gong P

    更新日期:2018-02-01 00:00:00

  • Mitochondrial gene mutations in patients with insulin-dependent diabetes mellitus in Taiwan.

    abstract::We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199604000-00006

    authors: Chuang LM,Wu HP,Tsai WY,Lai CS,Tai TY,Lin BJ

    更新日期:1996-04-01 00:00:00

  • In vivo assessment of lipid peroxidation in experimental edematous and necrotizing rat pancreatitis.

    abstract::Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199705000-00004

    authors: Lévy P,Lettéron P,Paye F,Molas G,Guimont MC,Pessayre D,Bernades P,Rozé C

    更新日期:1997-05-01 00:00:00

  • Use of Mammalian Target of Rapamycin Inhibitors for Pancreas Transplant Immunosuppression Is Associated With Improved Allograft Survival and Improved Early Patient Survival.

    abstract:OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000001322

    authors: Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

    更新日期:2019-05-01 00:00:00

  • Pancreatic cancer presenting with resolving pseudocyst during octreotide therapy.

    abstract::Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199307000-00016

    authors: Nugent CE,Lehman GA,Madura JA,Kopecky K

    更新日期:1993-07-01 00:00:00

  • Effects of early ductal decompression in human biliary acute pancreatitis.

    abstract::It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199803000-00010

    authors: Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

    更新日期:1998-03-01 00:00:00

  • Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans.

    abstract::Amylase inhibition has gastrointestinal and metabolic effects that may aid in the treatment of diabetes and obesity. We tested whether 4 g of a commercially available wheat amylase inhibitor (WAI) affected postprandial carbohydrate (CHO) absorption and plasma glucose or hormones. Twelve persons (four lean and four obe...

    journal_title:Pancreas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006676-199808000-00011

    authors: Lankisch M,Layer P,Rizza RA,DiMagno EP

    更新日期:1998-08-01 00:00:00

  • Aberrant expression of cdx2 homeobox gene in intraductal papillary-mucinous neoplasm of the pancreas but not in pancreatic ductal adenocarcinoma.

    abstract:OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/01.mpa.0000153615.55761.00

    authors: Yeh TS,Ho YP,Chiu CT,Chen TC,Jan YY,Chen MF

    更新日期:2005-04-01 00:00:00