Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis.


OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically suspected chronic pancreatitis and 21 healthy volunteers were evaluated. All subjects underwent MRI/MRCP and fecal elastase 1 testing within 1 to 4 weeks' interval. Magnetic resonance cholangiopancreatography images were evaluated according to Cambridge classification. Magnetic resonance imaging of the pancreas was assessed for pancreatic size, signal, and arterial enhancement. RESULTS:All volunteers had normal fecal elastase 1 levels (>200 microg/g) and normal MRI/MRCP findings. Thirty-one of 56 patients revealed MRI and/or MRCP findings despite normal fecal elastase 1 concentration. Four of 25 patients revealed normal MRI and MRCP findings despite low fecal elastase 1 concentration (<200 microg/g). Magnetic resonance imaging findings of size (P = 0.00001), arterial enhancement (P = 0.00001), and parenchymal signal (P = 0.001) were significantly different among the control group, patients with normal fecal elastase 1 levels, and patients with low fecal elastase 1 levels. Magnetic resonance cholangiopancreatography findings (P = 0.00001), pancreatic size (P = 0.00001), arterial enhancement (P = 0.014), and parenchymal signal (P = 0.004) on MRI correlated with the fecal elastase 1 concentration. CONCLUSIONS:Magnetic resonance imaging/MRCP findings correlate with fecal elastase 1 concentration and may precede pancreatic exocrine insufficiency in the early stages of chronic pancreatitis.






Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS




Has Abstract


2008-01-01 00:00:00
















  • Does acetylsalicylic acid interfere with stimulated pancreatic secretion? An experimental study in the rat.

    abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...


    pub_type: 杂志文章


    authors: Fabris C,Munaretto S,Basso D,Dodi G,Infantino A,Piccoli A,Meggiato T,Fogar P,Panozzo MP,Del Favero G

    更新日期:1993-07-01 00:00:00

  • Clinicopathologic Features and Germline Sequence Variants in Young Patients (≤40 Years Old) With Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...


    pub_type: 杂志文章


    authors: Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

    更新日期:2016-08-01 00:00:00

  • Dynamic aspects of granulocyte activation in rat severe acute pancreatitis.

    abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...


    pub_type: 杂志文章


    authors: Kimura Y,Hirota M,Okabe A,Inoue K,Kuwata K,Ohmuraya M,Ogawa M

    更新日期:2003-08-01 00:00:00

  • Efficacy of stone density on noncontrast computed tomography in predicting the outcome of extracorporeal shock wave lithotripsy for patients with pancreatic stones.

    abstract:OBJECTIVES:Patients with chronic pancreatitis are managed by extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones. Stone density on noncontrast computed tomography (NCCT) is used to predict stone composition and fragility, but no report investigating the pancreatic stone density has been documented. We ai...


    pub_type: 杂志文章


    authors: Ohyama H,Mikata R,Ishihara T,Tsuyuguchi T,Sakai Y,Sugiyama H,Yasui S,Ishii K,Itoh S,Nishikawa T,Watanabe Y,Yokosuka O

    更新日期:2015-04-01 00:00:00

  • An enzyme immunoassay for the determination of lipase in human duodenal fluid.

    abstract::The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...


    pub_type: 杂志文章


    authors: Hafkenscheid JC,Hessels M,Kerstens PJ,Lamers CB

    更新日期:1989-01-01 00:00:00

  • Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58.

    abstract:INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...


    pub_type: 杂志文章


    authors: Reeve JR Jr,McVey DC,Bunnett NW,Solomon TE,Keire DA,Ho FJ,Davis MT,Lee TD,Shively JE,Vigna SR

    更新日期:2002-10-01 00:00:00

  • Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers.

    abstract:OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...


    pub_type: 杂志文章


    authors: Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

    更新日期:2008-08-01 00:00:00

  • Future Directions in the Treatment of Gastrointestinal and Pancreatic Neuroendocrine Tumors.

    abstract::Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...


    pub_type: 杂志文章


    authors: Asmis T

    更新日期:2016-07-01 00:00:00

  • Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis.

    abstract:OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...


    pub_type: 杂志文章,多中心研究


    authors: Mayumi T,Inui K,Maetani I,Yokoe M,Sakamoto T,Yoshida M,Ko S,Hirata K,Takada T,Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group).

    更新日期:2012-08-01 00:00:00

  • Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy.

    abstract:OBJECTIVES:Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunoh...


    pub_type: 杂志文章


    authors: Nakashima A,Murakami Y,Uemura K,Hayashidani Y,Sudo T,Hashimoto Y,Ohge H,Oda M,Sueda T,Hiyama E

    更新日期:2009-07-01 00:00:00

  • Effects of early ductal decompression in human biliary acute pancreatitis.

    abstract::It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...


    pub_type: 杂志文章


    authors: Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

    更新日期:1998-03-01 00:00:00

  • Enhanced Recovery in Mild Acute Pancreatitis: A Randomized Controlled Trial.

    abstract:OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...


    pub_type: 杂志文章,随机对照试验


    authors: Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

    更新日期:2019-02-01 00:00:00

  • Gene Expression Profiling of the Pancreas in Patients Undergoing Total Pancreatectomy With Islet Autotransplant Suggests Unique Features of Alcoholic, Idiopathic, and Hereditary Pancreatitis.

    abstract:OBJECTIVES:To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies. METHODS:Data were assessed in 2 dimensions, based on RNA-seq si...


    pub_type: 杂志文章


    authors: Blobner BM,Bellin MD,Beilman GJ,Shelton CA,Park HJ,Whitcomb DC

    更新日期:2020-09-01 00:00:00

  • Coagulation, platelets, and acute pancreatitis.

    abstract::Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemos...


    pub_type: 杂志文章,评审


    authors: Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DP

    更新日期:2007-01-01 00:00:00

  • Risk factors for the development of intra-abdominal fungal infections in acute pancreatitis.

    abstract:OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...


    pub_type: 杂志文章


    authors: Schwender BJ,Gordon SR,Gardner TB

    更新日期:2015-07-01 00:00:00

  • The Research of Acellular Pancreatic Bioscaffold as a Natural 3-Dimensional Platform In Vitro.

    abstract:OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...


    pub_type: 杂志文章


    authors: Wang X,Li YG,Du Y,Zhu JY,Li Z

    更新日期:2018-09-01 00:00:00

  • Mitochondrial transcription factor a worsens the clinical course of patients with pancreatic cancer through inhibition of apoptosis of cancer cells.

    abstract:OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...


    pub_type: 杂志文章


    authors: Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

    更新日期:2014-04-01 00:00:00

  • Cholecystokinin stimulates a specific ribosomal S6 kinase in rat pancreatic acini.

    abstract::Stimulation of intact rat pancreatic acini with cholecystokinin (CCK) enhances the phosphorylation of the ribosomal protein S6 in a dose-dependent manner with half maximal stimulation at 40 pM and maximal stimulation at 1 nM CCK octapeptide. Soluble cellular extracts contained S6 kinase activity assayed using purified...


    pub_type: 杂志文章


    authors: Sung CK,Williams JA

    更新日期:1990-11-01 00:00:00

  • Reduction of immunogenicity by cyclophosphamide pretreatment and culture on xenograft survival of monkey pancreatic islets transplanted into rats.

    abstract:INTRODUCTION:Islet cell transplantation offers a new approach for the treatment of diabetes. Before transplantation, immunomodulation procedures are conducted to reduce the immunogenicity of the pancreatic islets. AIM:To study the effect of cyclophosphamide pretreatment and culture on the xenograft survival of monkey ...


    pub_type: 杂志文章


    authors: Mythili MD,Ramakrishna B,Gunasekaran S

    更新日期:2002-04-01 00:00:00

  • Heterogeneous cell renewal of pancreas in mice: [(3)H]-thymidine autoradiographic investigation.

    abstract:INTRODUCTION:Although cell kinetics of the gastrointestinal mucosa has been extensively examined, that of the pancreas has not been fully analyzed. AIM:To determine the renewal rate of pancreatic cells directly. METHODOLOGY:Postnatal proliferative activity and cellular renewal of the parenchymal cells in ICR mouse pa...


    pub_type: 杂志文章


    authors: Magami Y,Azuma T,Inokuchi H,Moriyasu F,Kawai K,Hattori T

    更新日期:2002-03-01 00:00:00

  • Microvessel Density and Impact of Angiogenesis on Survival of Resected Pancreatic Cancer Patients: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...


    pub_type: 杂志文章,meta分析


    authors: Ntellas P,Dadouli K,Perivoliotis K,Sogka E,Pentheroudakis G,Ioannou M,Hadjichristodoulou C,Tepetes K,Mauri D

    更新日期:2019-02-01 00:00:00

  • Decreased serum leptin concentration in patients with chronic pancreatitis.

    abstract:OBJECTIVE:Previously reported data suggest that serum leptin concentration changes in some acute and chronic inflammatory diseases. The aim of the present study was to assess serum leptin concentration in patients with chronic pancreatitis. METHODS:Forty-four male patients with chronic pancreatitis and 16 healthy (mal...


    pub_type: 杂志文章


    authors: Adrych K,Smoczynski M,Goyke E,Stelmanska E,Swierczynski J

    更新日期:2007-05-01 00:00:00

  • The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma.

    abstract:OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...


    pub_type: 杂志文章


    authors: Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

    更新日期:2017-05-01 00:00:00

  • Lipase synthesis in the rat pancreas is regulated by secretin.

    abstract::Conscious rats were infused with optimal doses of secretin (16 clinical units [CU]/kg/h), cerulein (0.25 microgram/kg/h), and both for varying periods of time over 24 h. The presence of zymogen granules in acinar cells and the tissue content of enzymes showed progressive decreases over 3 and 12 h for cerulein and secr...


    pub_type: 杂志文章


    authors: Rausch U,Rüdiger K,Vasiloudes P,Kern H,Scheele G

    更新日期:1986-01-01 00:00:00

  • Clinical Benefits of Telotristat Ethyl in Patients With Neuroendocrine Tumors and Low Bowel Movement Frequency: An Observational Patient-Reported Outcomes Study.

    abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...


    pub_type: 杂志文章


    authors: Benson AB 3rd,Strosberg J,Joish VN,Dharba S,Sapre D,Lapuerta P

    更新日期:2020-03-01 00:00:00

  • Nab-Paclitaxel Plus S-1 Shows Increased Antitumor Activity in Patient-Derived Pancreatic Cancer Xenograft Mouse Models.

    abstract:OBJECTIVES:To investigate the antitumor activity of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus S-1 in patient-derived pancreatic cancer xenograft mouse models and to explore biomarkers that could predict drug efficacy. METHODS:Ten patient-derived xenograft models were established. The third-generation...


    pub_type: 杂志文章


    authors: Li JA,Xu XF,Han X,Fang Y,Shi CY,Jin DY,Lou WH

    更新日期:2016-03-01 00:00:00

  • Combination treatment with comprehensive cryoablation and immunotherapy in metastatic pancreatic cancer.

    abstract:OBJECTIVE:The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer. METHODS:We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 pati...


    pub_type: 杂志文章


    authors: Niu L,Chen J,He L,Liao M,Yuan Y,Zeng J,Li J,Zuo J,Xu K

    更新日期:2013-10-01 00:00:00

  • Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.

    abstract:OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...


    pub_type: 杂志文章


    authors: Ueda K,Kawabe K,Lee L,Tachibana Y,Fujimori N,Igarashi H,Oda Y,Jensen RT,Takayanagi R,Ito T

    更新日期:2017-04-01 00:00:00

  • Hepatitis viruses causing pancreatitis and hepatitis: a case series and review of literature.

    abstract:OBJECTIVES:Association between acute pancreatitis and acute viral hepatitis (AVH) is more frequent than previously thought. Most cases are hepatitis A or B virus related. Only 6 cases of acute pancreatitis with acute hepatitis E virus (HEV)-related hepatitis has been reported so far. METHODS:We analyzed the hospital r...


    pub_type: 杂志文章


    authors: Bhagat S,Wadhawan M,Sud R,Arora A

    更新日期:2008-05-01 00:00:00

  • Histopathologic correlation of endoscopic ultrasound findings of chronic pancreatitis in human autopsies.

    abstract:OBJECTIVES:To provide histologic correlation of endoscopic ultrasound (EUS) findings believed to represent chronic pancreatitis (CP). METHODS:Eighteen postmortem pancreatic specimens in patients dying of all causes were examined in vitro by EUS for features of CP: (1) echogenic foci, (2) hypoechoic foci, (3) echogenic...


    pub_type: 杂志文章


    authors: Bhutani MS,Arantes VN,Verma D,Moezzi J,Suryaprasad S,Kapadia AS,Gopalswamy N

    更新日期:2009-10-01 00:00:00