Effects of dexamethasone on intercellular adhesion molecule 1 expression and inflammatory response in necrotizing acute pancreatitis in rats.

abstract：:Islet amyloid polypeptide (IAPP) is synthesized in islet B cells and stored in the secretory granules. We examined whether IAPP and insulin are released in parallel in humans. Arginine hydrochloride (5 g) was injected intravenously at three glucose levels in 11 healthy 58-year-old female subjects. In the fasting state...

journal_title：Pancreas

authors： Larsson H,Ahrén B

更新日期：1995-08-01 00:00:00

abstract：:In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...

journal_title：Pancreas

authors： Morales A,Cuéllar A,Ramírez J,Vilchis F,Díaz-Sánchez V

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

journal_title：Pancreas

authors： Shah P,Singh MH,Yang YX,Metz DC

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. METHODS:: In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant...

journal_title：Pancreas

authors： Webb MA,Illouz SC,Pollard CA,Gregory R,Mayberry JF,Tordoff SG,Bone M,Cordle CJ,Berry DP,Nicholson ML,Musto PP,Dennison AR

更新日期：2008-10-01 00:00:00

abstract：:Peptide YY (PYY) is a recently isolated gut peptide that is found primarily in the mucosal endocrine cells of the terminal ileum, colon, and rectum of several mammalian species, including humans. The purpose of this study was to characterize the effect of PYY on pancreatic exocrine secretion in six conscious dogs prep...

journal_title：Pancreas

authors： Lluis F,Gomez G,Fujimura M,Greeley GH Jr,Thompson JC

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...

journal_title：Pancreas

authors： Muehling B,Kolb A,Ramadani M,Schmidt E,Gansauge F,Beger HG

更新日期：2004-03-01 00:00:00

abstract：:Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...

journal_title：Pancreas

authors： Takaya H,Andoh A,Shimada M,Hata K,Fujiyama Y,Bamba T

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:To assess the degree of interobserver agreement of MRI in the diagnostic assessment of pancreatic cysts (PCs). METHODS:Magnetic resonance imaging sets of images of 62 patients with PCs (32 with histological confirmation and 30 with clinical diagnosis) were reviewed by 4 experienced radiologists. Features sc...

journal_title：Pancreas

authors： de Jong K,Nio CY,Mearadji B,Phoa SS,Engelbrecht MR,Dijkgraaf MG,Bruno MJ,Fockens P

更新日期：2012-03-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...

journal_title：Pancreas

authors： Arita Y,Kimura T,Ogami Y,Nawata H

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00

abstract：:The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...

journal_title：Pancreas

authors： Kuroda T,Shiohara E,Haba Y,Kaneko G,Hanazaki K,Kajikawa S,Iida F

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...

journal_title：Pancreas

authors： Einama T,Kagata Y,Tsuda H,Morita D,Ogata S,Ueda S,Takigawa T,Kawarabayashi N,Fukatsu K,Sugiura Y,Matsubara O,Hatsuse K

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...

journal_title：Pancreas

authors： Wang C,Yang A,Zhang B,Yin Q,Huang H,Chen M,Xie J

更新日期：2014-03-01 00:00:00

abstract：:Cutaneous metastasis of an occult malignancy to the umbilicus has come to be known as a Sister Mary Joseph's nodule (SMJN). More than 400 cases of this well-described clinical presentation of advanced gastrointestinal and gynecologic cancers have been reported. Pancreatic cancer presenting as a SMJN is a rare phenomen...

journal_title：Pancreas

authors： Yendluri V,Centeno B,Springett GM

更新日期：2007-01-01 00:00:00

abstract：:Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....

journal_title：Pancreas

authors： Gou S,Yu J,Wang C,Liu T,Cui P,Li X

更新日期：2013-01-01 00:00:00

abstract：:Changes in pancreatic growth and in mRNA concentrations in rat pancreas were monitored by dot-blot hybridization with cloned cDNAs of rat amylase, chymotrypsinogen B, proinsulin I, and actin during the pre- and postnatal period in the rat. Wistar rats were killed at the 18th day of gestation and at the 1st, 10th, 20th...

journal_title：Pancreas

authors： Iovanna JL,Dusetti N,Cadenas B,Calvo EL

更新日期：1990-07-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：:Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...

journal_title：Pancreas

authors： Göke B,Keim V,Dagorn JC,Arnold R,Adler G

更新日期：1990-05-01 00:00:00

abstract：INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...

journal_title：Pancreas

authors： Eibl G,Forgacs B,Hotz HG,Buhr HJ,Foitzik T

更新日期：2002-08-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...

journal_title：Pancreas

authors： Ueda K,Kawabe K,Lee L,Tachibana Y,Fujimori N,Igarashi H,Oda Y,Jensen RT,Takayanagi R,Ito T

更新日期：2017-04-01 00:00:00

abstract：:Nicotine is a possible risk factor for chronic pancreatitis and pancreatic cancer. To study the loci where nicotine might exert its effect, we examined interactions between nicotine and rat pancreatic acini. When pancreatic acini were incubated with [3H]nicotine, [3H]nicotine levels in pancreatic acini were increased ...

journal_title：Pancreas

authors： Doi R,Chowdhury P,Nishikawa M,Takaori K,Inoue K,Imamura M,Rayford PL

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:This study developed a novel protocol for creating an acute necrotizing pancreatitis model in rats using L-arginine. METHODS:Anesthetic laparotomy was performed on the upper abdomen, and the pancreatic parenchyma of Sprague-Dawley rats was injected with 1 mL of sterilized L-arginine solution at 5 different l...

journal_title：Pancreas

authors： Guo F,Zheng S,Gao X,Zhang Q,Liu J

更新日期：2015-03-01 00:00:00

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to perform an external validation of 2 Asian prognostic indices for patients with advanced pancreatic cancer. METHODS:A score was calculated in patients treated with frontline therapy derived from the factors Eastern Cooperative Oncology Group Performance Status, localization...

journal_title：Pancreas

authors： Haas M,Laubender RP,Klose C,Schulz C,Mansmann U,Boeck S,Heinemann V

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...

journal_title：Pancreas

authors： Estrella JS,Ma LT,Milton DR,Yao JC,Wang H,Rashid A,Broaddus RR

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METH...

journal_title：Pancreas

authors： da Silva A,Bowden M,Zhang S,Masugi Y,Thorner AR,Herbert ZT,Zhou CW,Brais L,Chan JA,Hodi FS,Rodig S,Ogino S,Kulke MH

更新日期：2018-10-01 00:00:00

abstract：:We examined whether pancreas grafts preserved by the two-layer method maintained adenine nucleotides pool as substrates for ATP synthesis before reperfusion and had the ability to recover pancreatic tissue perfusion and synthesize ATP promptly after reperfusion. After preservation by the two-layer cold storage method ...

journal_title：Pancreas

authors： Kim Y,Kuroda Y,Tanioka Y,Matsumoto S,Fujita H,Sakai T,Hamano M,Suzuki Y,Ku Y,Saitoh Y

更新日期：1997-04-01 00:00:00