Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis.

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00

abstract：INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...

journal_title：Pancreas

authors： Reeve JR Jr,McVey DC,Bunnett NW,Solomon TE,Keire DA,Ho FJ,Davis MT,Lee TD,Shively JE,Vigna SR

更新日期：2002-10-01 00:00:00

abstract：AIM:To assess the feasibility and usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) for evaluation of pancreatic exocrine function. METHODOLOGY:S-MRCP was performed in 20 patients with mild (n = 8) or severe (n = 12) chronic pancreatitis (according to the grade of exocrine pancreatic...

journal_title：Pancreas

authors： Czakó L,Endes J,Takács T,Boda K,Lonovics J

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVES:Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as ...

journal_title：Pancreas

authors： Miyasaka K,Kawanami T,Shimokata H,Ohta S,Funakoshi A

更新日期：2005-03-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：:In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...

journal_title：Pancreas

authors： Slimak GG,Stark HA,Egan JJ,Jensen RT,Gardner JD

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...

journal_title：Pancreas

authors： Coppola D,Helm J,Ghayouri M,Malafa MP,Wang HG

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Severe acute pancreatitis (SAP) remains a serious disease state difficult to manage. Laparoscopic surgery represents a relatively new solution to this problem. This study was aimed to investigate the feasibility of laparoscopic treatment of SAP and the selection of laparoscopic procedures in various stages...

journal_title：Pancreas

authors： Zhou ZG,Zheng YC,Shu Y,Hu WM,Tian BL,Li QS,Zhang ZD

更新日期：2003-10-01 00:00:00

abstract：:The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...

journal_title：Pancreas

authors： Terashima H,Debas HT,Bunnett NW

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...

journal_title：Pancreas

authors： Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

更新日期：2016-02-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is synthesized in islet B cells and stored in the secretory granules. We examined whether IAPP and insulin are released in parallel in humans. Arginine hydrochloride (5 g) was injected intravenously at three glucose levels in 11 healthy 58-year-old female subjects. In the fasting state...

journal_title：Pancreas

authors： Larsson H,Ahrén B

更新日期：1995-08-01 00:00:00

abstract：:The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...

journal_title：Pancreas

authors： Hafkenscheid JC,Hessels M,Kerstens PJ,Lamers CB

更新日期：1989-01-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

journal_title：Pancreas

authors： Jia D,Taguchi M,Otsuki M

更新日期：2005-01-01 00:00:00

abstract：:A 62-year-old man underwent distal pancreatectomy for invasive pancreatic carcinoma. Histopathologically, the main lesion that obstructed the main pancreatic duct and measured 2.0 cm in diameter was a moderately differentiated adenocarcinoma with marked neural invasion. The main pancreatic duct immediately distal to t...

journal_title：Pancreas

authors： Sanada Y,Masumoto T,Nishimura R

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...

journal_title：Pancreas

authors： Jia DM,Otsuki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS:We inhibited I...

journal_title：Pancreas

authors： Li JH,McMillan RH,Begum A,Gocke CB,Matsui W

更新日期：2019-01-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：:Chronic pancreatitis (CP) is one condition in which epidemiologic studies have demonstrated a definite association with pancreatic adenocarcinoma (PAC). The pathophysiologic and molecular events that either predispose to the development of, or potentiate the growth of, PAC are unknown. Mutation of the codon 12 K-ras g...

journal_title：Pancreas

authors： Banerjee SK,Zoubine MN,Mullick M,Weston AP,Cherian R,Campbell DR

更新日期：2000-04-01 00:00:00

abstract：:To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...

journal_title：Pancreas

authors： Kamisawa T,Isawa T,Koike M,Tsuruta K,Okamoto A

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP). METHODS:One hundred fifty-nine consecutive patients with SAP admitted to the intensive care units between January 2005 and December 2008 were incl...

journal_title：Pancreas

authors： Wilkman E,Kaukonen KM,Pettilä V,Kuitunen A,Varpula M

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to evaluate the severity of patients with acute pancreatitis (AP) on chronic pancreatitis (CP) and compare this to patients with AP without CP. METHODS:The Maryland Health Services database was queried for all adult inpatient discharges with a primary diagnosis of AP from 1...

journal_title：Pancreas

authors： Akshintala VS,Hutfless SM,Yadav D,Khashab MA,Lennon AM,Makary MA,Hirose K,Andersen DK,Kalloo AN,Singh VK

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...

journal_title：Pancreas

authors： Jo JH,Chung MJ,Park JY,Bang S,Park SW,Chung JB,Song SY

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...

journal_title：Pancreas

authors： Yang Z,Chen M,Fialkow LB,Ellett JD,Wu R,Nadler JL

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Image-guided radiation therapy allows precise tumor targeting using real-time tracking of radiopaque fiducial markers. To enable appropriate tracking, it is recommended to place fiducials with "ideal fiducial geometry" (IFG). Our objectives were to determine the proportion of patients in whom IFG can be achie...

journal_title：Pancreas

authors： Majumder S,Berzin TM,Mahadevan A,Pawa R,Ellsmere J,Sepe PS,Larosa SA,Pleskow DK,Chuttani R,Sawhney MS

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...

journal_title：Pancreas

authors： Azria D,Ychou M,Jacot W,Thezenas S,Lemanski C,Senesse P,Prost P,Delard R,Masson B,Dubois JB

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Pancreatic stellate cells (PSCs) are important players in pancreatic fibrosis and are major contributors to the extracellular matrix proteins observed with the stromal response characteristic of pancreatic ductal adenocarcinoma (PDAC). Pancreatic stellate cells are also believed to secrete soluble factors tha...

journal_title：Pancreas

authors： Wehr AY,Furth EE,Sangar V,Blair IA,Yu KH

更新日期：2011-05-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...

journal_title：Pancreas

authors： Langlois A,Morisset J

更新日期：1991-09-01 00:00:00

abstract：:Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...

journal_title：Pancreas

authors： Frantz ED,Peixoto-Silva N,Pinheiro-Mulder A

更新日期：2012-01-01 00:00:00