Synthesis of steroids in pancreas: evidence of cytochrome P-450scc activity.

abstract：OBJECTIVES:Patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) are at a higher risk of developing post-ERCP pancreatitis than patients undergoing diagnostic ERCP. The aim of this study was to evaluate the effectiveness of somatostatin in preventing post-therapeutic ERCP pancreatitis. ...

journal_title：Pancreas

authors： Lee KT,Lee DH,Yoo BM

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

journal_title：Pancreas

authors： Shah P,Singh MH,Yang YX,Metz DC

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...

journal_title：Pancreas

authors： Park HS,Yoon HS,Park YD,Cui ZY,Lee YL,Park HJ

更新日期：2002-05-01 00:00:00

abstract：:A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...

journal_title：Pancreas

authors： Lin JT,Wang TH,Chen DS,How SW,Lai MY,Chen JC,Sung JL

更新日期：1988-01-01 00:00:00

abstract：METHODOLOGY:The authors performed the reverse transcription-polymerase chain reaction (RT-PCR) in 17 cases of pancreatic ductal cell carcinoma (PDC) and five cases of normal pancreatic tissues to determine the expression of tumor necrosis factor -related apoptosis-inducing factor (TRAIL) and its five receptors in PDC. ...

journal_title：Pancreas

authors： Satoh K,Kaneko K,Hirota M,Masamune A,Satoh A,Shimosegawa T

更新日期：2001-10-01 00:00:00

abstract：:Abdominal and/or back pain is one of the most common symptoms in patients with pancreatic cancer. However, the cause of the pain and the clinicopathologic features of patients with pain have not been fully elucidated. We retrospectively determined the factors related to preoperative abdominal and/or back pain in 95 pa...

journal_title：Pancreas

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Shimada K,Yamamoto J,Kosuge T,Yamasaki S,Fukushima N,Sakamoto M

更新日期：2001-04-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...

journal_title：Pancreas

authors： Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

更新日期：2008-08-01 00:00:00

abstract：:Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...

journal_title：Pancreas

authors： De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

更新日期：2003-10-01 00:00:00

abstract：:Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....

journal_title：Pancreas

authors： Gou S,Yu J,Wang C,Liu T,Cui P,Li X

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...

journal_title：Pancreas

authors： Inui K,Masamune A,Igarashi Y,Ohara H,Tazuma S,Sugiyama M,Suzuki Y,Miyoshi H,Yamamoto S,Takeyama Y,Nakano E,Takuma K,Sakagami J,Hayashi K,Kogure A,Ito T,Mukai T,Maetani I,Nagahama M,Serikawa M,Ueki T,Furuya K,I

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...

journal_title：Pancreas

authors： Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

更新日期：2010-08-01 00:00:00

abstract：:Metastatic pancreatic cancer (PC) is an aggressive malignancy, with most patients deriving benefit only from first-line chemotherapy. Increasingly, the recommended treatment for those with a germline mutation in a gene involved in homologous recombination repair is with a platinum drug followed by a poly (ADP-ribose) ...

journal_title：Pancreas

authors： Martino C,Pandya D,Lee R,Levy G,Lo T,Lobo S,Frank RC

更新日期：2020-01-01 00:00:00

abstract：:The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...

journal_title：Pancreas

authors： Terashima H,Debas HT,Bunnett NW

更新日期：1992-01-01 00:00:00

abstract：:Despite the new diagnostic and therapeutic advancements, acute pancreatitis has still high rate of morbidity and mortality. We aimed to evaluate the effects of hyperbaric oxygen (HBO) therapy alone or combined with S-methylisothiourea (SMT), and meropenem (MER) therapy in an experimental rat model of acute necrotizing...

journal_title：Pancreas

authors： Isik AT,Mas MR,Comert B,Yasar M,Korkmaz A,Akay C,Deveci S,Tasci I,Mas N,Ates Y,Kocar IH

更新日期：2004-01-01 00:00:00

abstract：:Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...

journal_title：Pancreas

authors： Wu F,Jagir M,Powell JS

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:Pancreatic functions were determined in a Ki-ras-induced actin-interacting protein (KRAP)-deficient (-/-) mouse mutant. METHODS:Pancreatic enzyme, protein, and DNA contents were measured, and histological examinations were conducted. The mixture of bile-pancreatic juice was collected, and amylase and bile a...

journal_title：Pancreas

authors： Miyasaka K,Fujimoto T,Kawanami T,Takiguchi S,Jimi A,Funakoshi A,Shirasawa S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunoh...

journal_title：Pancreas

authors： Nakashima A,Murakami Y,Uemura K,Hayashidani Y,Sudo T,Hashimoto Y,Ohge H,Oda M,Sueda T,Hiyama E

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:To investigate embryology of complete and incomplete pancreas divisum (PD). METHODS:We analyzed anatomy of the pancreatic duct system in 44 cases of complete PD and 41 cases of incomplete PD. Under the concept of branch fusion between the ventral and dorsal pancreatic ducts, incomplete PD was divided into 3...

journal_title：Pancreas

authors： Kamisawa T,Egawa N,Tu Y,Tsuruta K,Okamoto A

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...

journal_title：Pancreas

authors： Ramudo L,Yubero S,Manso MA,Sanchez-Recio J,Weruaga E,De Dios I

更新日期：2010-10-01 00:00:00

abstract：:This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...

journal_title：Pancreas

authors： Lankisch PG,Pflichthofer D,Lehnick D

更新日期：1999-11-01 00:00:00

abstract：:Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...

journal_title：Pancreas

authors： Roza AM,Pieper GM,Johnson CP,Adams MB

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...

journal_title：Pancreas

authors： Schneider L,Hackert T,Longerich T,Hartwig W,Fritz S,Krych R,Fortunato F,Gebhard MM,Werner J

更新日期：2010-05-01 00:00:00

abstract：:To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...

journal_title：Pancreas

authors： Lee YL,Kwon HY,Park HS,Lee TH,Park HJ

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine,...

journal_title：Pancreas

authors： Steele CW,Oien KA,McKay CJ,Jamieson NB

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：:Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive ja...

journal_title：Pancreas

authors： Estrella JS,Wang H,Bhosale PR,Evans HL,Abraham SC

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...

journal_title：Pancreas

authors： Shea K,Rouse R

更新日期：2019-09-01 00:00:00