Abstract:
:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice received seven intraperitoneal injections of cerulein at hourly intervals, at doses ranging from physiological (0.1 micrograms/kg) to pharmacological (50 micrograms/kg). A single dose of cerulein induced a 28-33% decrease in ATP, whereas a complete course of injections led to a nadir as low as 45% of the control value. The overall pattern of ATP tissue content during the observed time course was surprisingly similar in all four groups and statistically not different at any time point. Until 12 h, ATP levels in all groups remained below the control value. In contrast, serum amylase and light microscopy reflected a degree of pancreatitis in a close dose-response pattern to the administered cerulein dose. These findings suggest that ATP depletion--although probably facilitating acinar damage--does not seem to play a causal or primary role in the pathophysiology of acute pancreatitis.
journal_name
Pancreasjournal_title
Pancreasauthors
Lüthen RE,Niederau C,Ferrell LD,Grendell JHdoi
10.1097/00006676-199508000-00005subject
Has Abstractpub_date
1995-08-01 00:00:00pages
141-6issue
2eissn
0885-3177issn
1536-4828journal_volume
11pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001587
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS:Thirty-nine pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000917
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:An impaired host immunity might concur in determining the dismal prognosis of patients with pancreatic cancer (PC). Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival. METHODS:We studied 115 patients with PC, 44 with chroni...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000188305.90290.50
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001019
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318053eae2
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31811f44fd
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001434
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31812e9688
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000835
更新日期:2017-07-01 00:00:00
abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00004
更新日期:1987-01-01 00:00:00
abstract::To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198611000-00001
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200210000-00021
更新日期:2002-10-01 00:00:00
abstract::The involvement of endogenous prostaglandins (PGs) in pancreatic endocrine and exocrine secretion was investigated, using the isolated and perfused dog pancreas. Spontaneous production of both PGE2 and 6-keto-PGF1 alpha was recorded in venous effluent. Prostaglandin production increased following stimulation with both...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198912000-00008
更新日期:1989-01-01 00:00:00
abstract::Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3182236320
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS:A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000000990
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182480ab7
更新日期:2012-08-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess the oxidative stress markers and antioxidant defense system in patients with CP and those with PC. METHODS:Activities of superoxide dismutase 1 (SOD1), catalase (CAT)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318288360a
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS:We inhibited I...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001198
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001606
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer. METHODS:We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 pati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182965dde
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001557
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000434
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB). This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP). METHODS:Male CD mice (median weight,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181b28d11
更新日期:2009-11-01 00:00:00
abstract::A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00003
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...
journal_title:Pancreas
pub_type: 杂志文章,meta分析
doi:10.1097/MPA.0000000000001237
更新日期:2019-02-01 00:00:00
abstract::The transport specificity of L-glutamine influx in the perfused rat exocrine pancreas has been investigated using a dual isotope tracer dilution technique. During a single circulation through the isolated pancreas, an epithelial uptake of 71 +/- 1% (n = 10) was measured for L-(3H)glutamine relative to the extracellula...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198605000-00007
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182649979
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181baac47
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000087
更新日期:2014-03-01 00:00:00