Impact of Antibiotic-Resistant Bacterial and Fungal Infections in Outcome of Acute Pancreatitis.

abstract：:Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...

journal_title：Pancreas

authors： Nakano S,Tachibana I,Otsuki M

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:Benign pancreatic hyperenzymemia is characterized by a long-term increase of serum pancreatic enzymes in otherwise healthy subjects. This study was designed to determine (a) whether all pancreatic enzymes are elevated, (b) the extent of each enzyme increase, (c) the relative frequency of the familial form, an...

journal_title：Pancreas

authors： Galassi E,Birtolo C,Migliori M,Bastagli L,Gabusi V,Stanghellini V,De Giorgio R

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...

journal_title：Pancreas

authors： Ben Q,An W,Wang L,Wang W,Yu L,Yuan Y

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00

abstract：:To study the influence of extracellular matrix (ECM) on isolated fetal porcine islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel (MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix for 20 days. The insulin accumulation in the culture medium was determined every fifth...

journal_title：Pancreas

authors： Oberg-Welsh C

更新日期：2001-03-01 00:00:00

abstract：:Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...

journal_title：Pancreas

authors： Lévy P,Lettéron P,Paye F,Molas G,Guimont MC,Pessayre D,Bernades P,Rozé C

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

journal_title：Pancreas

authors： Jia D,Taguchi M,Otsuki M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...

journal_title：Pancreas

authors： Gougol A,Machicado JD,Matta B,Paragomi P,Pothoulakis I,Slivka A,Whitcomb DC,Yadav D,Papachristou GI

更新日期：2019-11-01 00:00:00

abstract：:The transport specificity of L-glutamine influx in the perfused rat exocrine pancreas has been investigated using a dual isotope tracer dilution technique. During a single circulation through the isolated pancreas, an epithelial uptake of 71 +/- 1% (n = 10) was measured for L-(3H)glutamine relative to the extracellula...

journal_title：Pancreas

authors： Mann GE,Habara Y,Peran S

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...

journal_title：Pancreas

authors： Negrelli R,Boninsegna E,Avesani G,Zamboni GA,Brozzi L,Frulloni L,Manfredi R,Pozzi Mucelli R

更新日期：2018-10-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) binding sites in adult rat exocrine pancreas were studied by autoradiography using slide-mounted frozen tissue sections with mono-iodinated ANF (101-126) as the tracer. Radiolabel was displaced by unlabeled atrial peptide (IC50 = 2 X 10(-11) M). High specific labeling was found in pancr...

journal_title：Pancreas

authors： Chabot JG,Morel G,Kopelman H,Belles-Isles M,Heisler S

更新日期：1987-01-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METH...

journal_title：Pancreas

authors： da Silva A,Bowden M,Zhang S,Masugi Y,Thorner AR,Herbert ZT,Zhou CW,Brais L,Chan JA,Hodi FS,Rodig S,Ogino S,Kulke MH

更新日期：2018-10-01 00:00:00

abstract：:Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...

journal_title：Pancreas

authors： Conget I,Sarri Y,Somoza N,Vives M,Novials A,Ariza A,Fernández-Alvarez J,Pujol-Borrell R,Gomis R

更新日期：1997-01-01 00:00:00

abstract：:A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...

journal_title：Pancreas

authors： Lee WY,Tzeng CC,Jin YT,Chow NH,Yip CM,Lee JC

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution to...

journal_title：Pancreas

authors： Amodio A,De Marchi G,Granato A,de Pretis N,Gabbrielli A,Manfredi R,Pozzi Mucelli R,Frulloni L

更新日期：2019-04-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：:Several reports have described a loss of endogenous antioxidants and molecular oxidative damage during acute pancreatitis. Since hyaluronic acid and chondroitin-4-sulfate possess antioxidant properties, the effect of the administration of these glycosaminoglycans in a cerulein-induced acute pancreatitis in rats was in...

journal_title：Pancreas

authors： Campo GM,Avenoso A,Campo S,Ferlazzo AM,Calatroni A

更新日期：2004-03-01 00:00:00

abstract：:In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia t...

journal_title：Pancreas

authors： Konishi Y,Tsutsumi M,Tsujiuchi T

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：:We have studied the degree of pancreatic secretory alterations assessed by secretin-cerulein test (S-C) in relation to various morphological changes detected by real-time ultrasonography (US) in 42 patients affected by chronic pancreatitis. Exocrine insufficiency was found in 41 patients (97.6%), while morphological a...

journal_title：Pancreas

authors： Bolondi L,Priori P,Gullo L,Santi V,Li Bassi S,Barbara L,Labó G

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the tumor necrosis factor alpha (TNF-alpha) releasing capacity in whole blood stimulated by lipopolysaccharide (LPS) in patients with pancreatic cancer during the perioperative period, and before and after chemotherapy. METHODS:The current study involved a total of 39 pa...

journal_title：Pancreas

authors： Terakawa N,Satoi S,Takai S,Yanagimoto H,Takahashi K,Komiyama Y,A-Hon K,Kamiyama Y,Takahashi H

更新日期：2006-07-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...

journal_title：Pancreas

authors： Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

更新日期：1998-05-01 00:00:00

abstract：:Neuroendocrine tumors (NETs) arise in most organs of the body and share many common pathologic features. However, a variety of different organ-specific systems have been developed for nomenclature, grading, and staging of NETs, causing much confusion. This review examines issues in the pathologic assessment of NETs th...

journal_title：Pancreas

authors： Klimstra DS,Modlin IR,Coppola D,Lloyd RV,Suster S

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To establish new biomarkers for accurate diagnosis of pancreatic cancer (PC) using a standardized serum peptidome profiling and compare the results with those from the tumor marker, CA 19-9. METHODS:Serum samples from 102 patients (55 with chronic pancreatitis and 47 with PC) and 56 healthy controls were col...

journal_title：Pancreas

authors： Zapico-Muñiz E,Farré-Viladrich A,Rico-Santana N,González-Sastre F,Mora-Brugués J

更新日期：2010-11-01 00:00:00

abstract：:Opioid growth factor (OGF, [Met5]-enkephalin) is an endogenous peptide that regulates the growth of human pancreatic cancer. To evaluate whether human subjects with pancreatic cancer have alterations in plasma levels of OGF, fasting blood samples were obtained from 15 patients with histologically confirmed pancreatic ...

journal_title：Pancreas

authors： Smith JP,Conter RL,Demers TM,McLaughlin PJ,Zagon IS

更新日期：2000-08-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...

journal_title：Pancreas

authors： Morinville VD,Barmada MM,Lowe ME

更新日期：2010-01-01 00:00:00