Abstract:
:Several reports have described a loss of endogenous antioxidants and molecular oxidative damage during acute pancreatitis. Since hyaluronic acid and chondroitin-4-sulfate possess antioxidant properties, the effect of the administration of these glycosaminoglycans in a cerulein-induced acute pancreatitis in rats was investigated. Cerulein administration produced pancreatic edema and a marked increase in serum lipase and amylase activity; induced a severe depletion of reduced glutathione, catalase, and superoxide dismutase levels; primed lipid peroxidation; and promoted neutrophil intervention. Intraperitoneal pretreatment of rats with hyaluronic acid or chondroitin-4-sulfate or with both compounds ameliorated pancreatic cell conditions; restored the endogenous antioxidants reduced glutathione, catalase and superoxide dismutase; limited cell membrane peroxidation; and reduced neutrophil activation. Our data confirm the antioxidant activity of these 2 glycosaminoglycans.
journal_name
Pancreasjournal_title
Pancreasauthors
Campo GM,Avenoso A,Campo S,Ferlazzo AM,Calatroni Adoi
10.1097/00006676-200403000-00019subject
Has Abstractpub_date
2004-03-01 00:00:00pages
E45-53issue
2eissn
0885-3177issn
1536-4828pii
00006676-200403000-00019journal_volume
28pub_type
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