Microvessel Density and Impact of Angiogenesis on Survival of Resected Pancreatic Cancer Patients: A Systematic Review and Meta-analysis.

abstract：OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...

journal_title：Pancreas

authors： LaBarre NT,Morgan KA,Adams DB,Waljee AK,Coté GA,Elmunzer BJ

更新日期：2019-01-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:Glucocorticoids are effective in the treatment of certain leukemias and lymphomas, but their effects on the growth of several solid tumors have not been determined. We report here that cortivazol (CVZ), a potent synthetic glucocorticoid, inhibits the growth of a hamster pancreatic adenocarcinoma, H2T, in vivo. CVZ reg...

journal_title：Pancreas

authors： Evers BM,Thompson EB,Townsend CM Jr,Lawrence JL,Johnson B,Srinivasan G,Thompson JC

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...

journal_title：Pancreas

authors： Goldstein D,Von Hoff DD,Chiorean EG,Reni M,Tabernero J,Ramanathan RK,Botteman M,Aly A,Margunato-Debay S,Lu B,Louis CU,McGovern D,Lee CK

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...

journal_title：Pancreas

authors： Apodaca-Torrez FR,Goldenberg A,Lobo EJ,Farah JF,Triviño T,Montero EF,Schraibman V,Benvenuto RB,Artigiani Neto R

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...

journal_title：Pancreas

authors： Schlosser W,Gansauge F,Schlosser S,Gansauge S,Beger HG

更新日期：2001-11-01 00:00:00

abstract：:These studies were undertaken to assess the effects of chronic administration of cerulein plus secretin, every 8 h for 10 days on fluid, protein, and somatostatin-like immunoreactivity (SLI) outputs in rat pancreatic juice. Pancreatic secretion was studied with conscious, cannulated rats, during infusion of precollect...

journal_title：Pancreas

authors： Sarfati P,Green GM,Morisset J

更新日期：1988-01-01 00:00:00

abstract：:We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Tsai WY,Lai CS,Tai TY,Lin BJ

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...

journal_title：Pancreas

authors： Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00

abstract：AIM:To assess the feasibility and usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) for evaluation of pancreatic exocrine function. METHODOLOGY:S-MRCP was performed in 20 patients with mild (n = 8) or severe (n = 12) chronic pancreatitis (according to the grade of exocrine pancreatic...

journal_title：Pancreas

authors： Czakó L,Endes J,Takács T,Boda K,Lonovics J

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...

journal_title：Pancreas

authors： Li Y,Li G,Dong W,Chen J,Lu D,Tan J

更新日期：2006-10-01 00:00:00

abstract：:Over 80% of adenocarcinomas of the pancreas originate from duct cells, which are the major source of mucins in the pancreas. Pathological conditions produce changes in the composition and structure of the oligosaccharides of colonic and pancreatic mucins, and it has been suggested that mucins may have a role in the de...

journal_title：Pancreas

authors： Ho JJ,Kim YS

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...

journal_title：Pancreas

authors： Cizginer S,Turner BG,Bilge AR,Karaca C,Pitman MB,Brugge WR

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:An impaired host immunity might concur in determining the dismal prognosis of patients with pancreatic cancer (PC). Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival. METHODS:We studied 115 patients with PC, 44 with chroni...

journal_title：Pancreas

authors： Fogar P,Sperti C,Basso D,Sanzari MC,Greco E,Davoli C,Navaglia F,Zambon CF,Pasquali C,Venza E,Pedrazzoli S,Plebani M

更新日期：2006-01-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：:The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...

journal_title：Pancreas

authors： Natsume T,Watanabe Y,Maruyama T,Tanaka H,Sunouchi K,Tohma T,Noju M,Muto Y,Tohnosu N,Uehara T,Shimizu S,Ochiai T,Nabeya Y

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...

journal_title：Pancreas

authors： Aoufi Rabih S,García Agudo R,Legaz Huidobro ML,Ynfante Ferrús M,González Carro P,Pérez Roldán F,Ruiz Carrillo F,Tenías Burillo JM

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...

journal_title：Pancreas

authors： Yang Z,Chen M,Fialkow LB,Ellett JD,Wu R,Nadler JL

更新日期：2003-05-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...

journal_title：Pancreas

authors： Mouratidis PX,Dalgleish AG,Colston KW

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...

journal_title：Pancreas

authors： Hane Y,Tsuchikawa T,Nakamura T,Hatanaka KC,Saito T,Tanaka K,Nakanishi Y,Asano T,Noji T,Okamura K,Shichinohe T,Yokota I,Hatanaka Y,Hirano S

更新日期：2020-10-01 00:00:00

abstract：:A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...

journal_title：Pancreas

authors： Lee WY,Tzeng CC,Jin YT,Chow NH,Yip CM,Lee JC

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...

journal_title：Pancreas

authors： Jia DM,Otsuki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Protein kinase C (PKC) is involved in cell growth, differentiation, and apoptosis. We investigated the effects of the PKC activator, the tetradecanylphorbol acetate (TPA), in human pancreatic cancer cells. METHODS:Cell proliferation was measured by thymidine incorporation. Expression of cell cycle proteins ...

journal_title：Pancreas

authors： Salabat MR,Ding XZ,Flesche JB,Ujiki MB,Robin TP,Talamonti MS,Bell RH Jr,Adrian TE

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...

journal_title：Pancreas

authors： Rosenblum RE,Harris CK,Baeg KJ,Starr JA,Brais LK,Stashek KM,Ward SC,Katona BW,Clancy TE,Wisnivesky JP,Kulke MH,Metz DC,Kim MK,Chan JA

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS:MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measure...

journal_title：Pancreas

authors： Baker AF,Koh MY,Williams RR,James B,Wang H,Tate WR,Gallegos A,Von Hoff DD,Han H,Powis G

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:Pancreatic ductal adenocarcinoma remains as a chemoresistant disease with the poorest prognosis. Gemcitabine has been the standard treatment during the last decade. Erlotinib, a tyrosine kinase inhibitor, in combination with gemcitabine produces a small increase in survival. However, these results remain ins...

journal_title：Pancreas

authors： Torres C,Linares A,Alejandre MJ,Palomino-Morales RJ,Delgado JR,Perales S

更新日期：2016-02-01 00:00:00