Low serum levels of CD44, CD44v6, and neopterin indicate immune dysfunction in chronic pancreatitis.

abstract：OBJECTIVES:Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries. The present study examined the effect and cost of GM for AP treatment using the Japanese Diagnosis Procedure Combination database. METHODS:We performed a propensity score anal...

journal_title：Pancreas

authors： Yasunaga H,Horiguchi H,Hashimoto H,Matsuda S,Fushimi K

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:The role of melatonin in human insulin regulation is poorly understood. AIM:To investigate the influence of melatonin supplementation on glucose and insulin levels and on lipid metabolism in blood serum and the liver. METHODOLOGY:The acute melatonin effects on insulin secretion in male Wistar rats were i...

journal_title：Pancreas

authors： Fabiś M,Pruszyńska E,Maćkowiak P

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirme...

journal_title：Pancreas

authors： Kouerinis IA,Zografos G,Tarassi KE,Athanasiades TH,Liontos M,Gorgoulis VG,Korkolis D,Konstandoulakis MM,Fotiadis CI,Androulakis G,Papasteriades CA

更新日期：2004-07-01 00:00:00

abstract：:A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...

journal_title：Pancreas

authors： Iwai K,Fushiki T,Fukuoka S

更新日期：1988-01-01 00:00:00

abstract：UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...

journal_title：Pancreas

authors： Chang MC,Chang YT,Su TC,Yang WS,Chen CL,Tien YW,Liang PC,Wei SC,Wong JM

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...

journal_title：Pancreas

authors： Ortega AR,Gómez-Rodríguez R,Romero M,Fernández-Zapardiel S,Céspedes Mdel M,Carrobles JM

更新日期：2011-03-01 00:00:00

abstract：:Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...

journal_title：Pancreas

authors： Bhat ST,Talkad VD,Pollo DA,Gardner JD

更新日期：1994-01-01 00:00:00

abstract：:In a previous retrospective case-control study, hemoconcentration was associated with the development of pancreatic necrosis. The aim of the present study was to determine in a cohort study whether hemoconcentration is a marker for both organ failure and necrotizing pancreatitis. A cohort study was performed on patien...

journal_title：Pancreas

authors： Brown A,Orav J,Banks PA

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...

journal_title：Pancreas

authors： Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner H

更新日期：2016-07-01 00:00:00

abstract：:Clinical and translational research is critical for the development of improvement in care of pancreatic diseases. Major concerns are the lack of dedicated trainees in pancreatic research and the difficulty for the remaining trainees to develop independent research careers to be included into the pancreas research com...

journal_title：Pancreas

authors： Gelrud A,Whitcomb DC

更新日期：2010-04-01 00:00:00

abstract：:The nuclear DNA content was assessed by image cytometry on cytologic specimens obtained with fine-needle aspiration biopsy in 96 patients with pancreatic duct carcinoma. Twenty-two of these patients had pancreaticoduodenal resection. According to DNA analysis there were 27 (28%) diploid, 17 (18%) tetraploid, and 52 (5...

journal_title：Pancreas

authors： Linder S,Falkmer U,Hagmar T,Blåsjö M,Sundelin P,von Rosen A

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...

journal_title：Pancreas

authors： Rocha-Santos V,Ferro OC,Pantanali CA,Seixas MP,Pecora RA,Pinheiro RS,Claro LC,Abdo EE,Chaib E,D'Albuquerque LA

更新日期：2014-08-01 00:00:00

abstract：:It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to deter...

journal_title：Pancreas

authors： Henry JP,Steinberg WM

更新日期：1993-09-01 00:00:00

abstract：:A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...

journal_title：Pancreas

authors： Kolar C,Caffrey T,Hollingsworth M,Scheetz M,Sutherlin M,Weide L,Lawson T

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...

journal_title：Pancreas

authors： Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

更新日期：2016-02-01 00:00:00

abstract：:Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcin...

journal_title：Pancreas

authors： Yong WH,Southern JF,Pins MR,Warshaw AL,Compton CC,Lewandrowski KB

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...

journal_title：Pancreas

authors： Karabatas LM,Pastorale C,de Bruno LF,Maschi F,Pivetta OH,Lombardo YB,Chemes H,Basabe JC

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:Pancreatic functions were determined in a Ki-ras-induced actin-interacting protein (KRAP)-deficient (-/-) mouse mutant. METHODS:Pancreatic enzyme, protein, and DNA contents were measured, and histological examinations were conducted. The mixture of bile-pancreatic juice was collected, and amylase and bile a...

journal_title：Pancreas

authors： Miyasaka K,Fujimoto T,Kawanami T,Takiguchi S,Jimi A,Funakoshi A,Shirasawa S

更新日期：2011-01-01 00:00:00

abstract：:Human pure pancreatic juice (PPJ) and serum were analyzed for free fatty acids (FFAs) to study whether the damage to pancreatic cell membranes in pancreatitis is reflected as abnormal FFAs concentration and composition. Patients consisted of 13 normal controls, 7 patients with acute pancreatitis (AP) in remission, and...

journal_title：Pancreas

authors： Miyake H,Harada H,Ochi K,Oka H,Ishibashi T,Kimura I

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Previously reported data suggest that serum leptin concentration changes in some acute and chronic inflammatory diseases. The aim of the present study was to assess serum leptin concentration in patients with chronic pancreatitis. METHODS:Forty-four male patients with chronic pancreatitis and 16 healthy (mal...

journal_title：Pancreas

authors： Adrych K,Smoczynski M,Goyke E,Stelmanska E,Swierczynski J

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...

journal_title：Pancreas

authors： Klöppel G,Lüttges J,Löhr M,Zamboni G,Longnecker D

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION AND AIMS:Extracellular matrix (ECM) components participate in the process of tissue repair and development of fibrosis in the pancreas. We studied the production kinetics of ECM components and transforming growth factor (TGF)-beta1 and identified their production sites in the pancreas following pancreatiti...

journal_title：Pancreas

authors： Tashiro M,Nakamura H,Taguchi M,Yamaguchi T,Yoshikawa H,Fukumitsu K,Kihara Y,Otsuki M

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP). METHODS:One hundred fifty-nine consecutive patients with SAP admitted to the intensive care units between January 2005 and December 2008 were incl...

journal_title：Pancreas

authors： Wilkman E,Kaukonen KM,Pettilä V,Kuitunen A,Varpula M

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:A selective therapy for pancreatitis is total pancreatectomy and islet autotransplantation. Outcomes and geographical variability of patients who had total pancreatectomy (TP) alone or total pancreatectomy with islet autotransplantation (TPIAT) were assessed. METHODS:Data were obtained from the Healthcare C...

journal_title：Pancreas

authors： Lara LF,Bellin MD,Ugbarugba E,Nathan JD,Witkowski P,Wijkstrom M,Steel JL,Smith KD,Singh VK,Schwarzenberg SJ,Pruett TL,Naziruddin B,Long-Simpson L,Kirchner VA,Gardner TB,Freeman ML,Dunn TB,Chinnakotla S,Beilman GJ,Ad

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:To investigate the antitumor activity of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus S-1 in patient-derived pancreatic cancer xenograft mouse models and to explore biomarkers that could predict drug efficacy. METHODS:Ten patient-derived xenograft models were established. The third-generation...

journal_title：Pancreas

authors： Li JA,Xu XF,Han X,Fang Y,Shi CY,Jin DY,Lou WH

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...

journal_title：Pancreas

authors： Aoufi Rabih S,García Agudo R,Legaz Huidobro ML,Ynfante Ferrús M,González Carro P,Pérez Roldán F,Ruiz Carrillo F,Tenías Burillo JM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Opioid therapy for pain in chronic pancreatitis (CP) is associated with tolerance and possibly opioid-induced hyperalgesia. We thus examined opioid use and pain rating in CP patients. METHODS:Medical records of patients with established CP treated at the University of Pittsburgh Medical Center's Digestive Di...

journal_title：Pancreas

authors： Nusrat S,Yadav D,Bielefeldt K

更新日期：2012-03-01 00:00:00

abstract：:Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...

journal_title：Pancreas

authors： Nakano S,Tachibana I,Otsuki M

更新日期：1995-04-01 00:00:00