Abstract:
UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time of diagnosis in patients with CP and PC. METHODS:Serum ADP and CA-19-9 levels were measured by immunoassays in 72 patients with PC and 39 with CP and 290 control subjects. RESULTS:The median levels of ADP for PC were significantly higher than those for CP and control subjects (P = 0.0035). Increasing the upper reference value of ADP allowed for better discrimination between CP and PC. The introduction of 28 ng/mL as a cutoff for ADP significantly improved its specificity. At an elevated cutoff level for ADP (28 ng/mL), a better discrimination between PC and CP was obtained. CONCLUSIONS:Adiponectin might be useful in the differential diagnosis of PC and CP with elevated CA-19-9. This gives rise to the possibility that ADP has a potential role in differentiating CP and PC.
journal_name
Pancreasjournal_title
Pancreasauthors
Chang MC,Chang YT,Su TC,Yang WS,Chen CL,Tien YW,Liang PC,Wei SC,Wong JMdoi
10.1097/MPA.0b013e3180547709subject
Has Abstractpub_date
2007-07-01 00:00:00pages
16-21issue
1eissn
0885-3177issn
1536-4828pii
00006676-200707000-00002journal_volume
35pub_type
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