Immunohistochemical and molecular analysis of giant cell carcinoma of the pancreas: a report of three cases.

abstract：OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...

journal_title：Pancreas

authors： Rogers MB,Aveson V,Firek B,Yeh A,Brooks B,Brower-Sinning R,Steve J,Banfield JF,Zureikat A,Hogg M,Boone BA,Zeh HJ,Morowitz MJ

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...

journal_title：Pancreas

authors： Karabatas LM,Pastorale C,de Bruno LF,Maschi F,Pivetta OH,Lombardo YB,Chemes H,Basabe JC

更新日期：2005-05-01 00:00:00

abstract：:Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemos...

journal_title：Pancreas

authors： Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DP

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...

journal_title：Pancreas

authors： Tian Y,Xue Y,Ruan G,Cheng K,Tian J,Qiu Q,Xiao M,Li H,Yang H,Wang L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...

journal_title：Pancreas

authors： Yeh TS,Ho YP,Chiu CT,Chen TC,Jan YY,Chen MF

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...

journal_title：Pancreas

authors： Khan D,Abureesh M,Alkhayyat M,Sadiq W,Alshami M,Munir AB,Karam B,Deeb L,Lafferty J

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...

journal_title：Pancreas

authors： Takai S,Satoi S,Toyokawa H,Yanagimoto H,Sugimoto N,Tsuji K,Araki H,Matsui Y,Imamura A,Kwon AH,Kamiyama Y

更新日期：2003-04-01 00:00:00

abstract：:The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without possibility of cure. Although in recent years there have been some new promising chemotherapy regimens that improve overall survival by a few months, the prognosis re...

journal_title：Pancreas

authors： Shah R,Ostapoff KT,Kuvshinoff B,Hochwald SN

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...

journal_title：Pancreas

authors： Watanabe H,Okada G,Ohtsubo K,Yao F,Jiang PH,Mouri H,Wakabayashi T,Sawabu N

更新日期：2006-05-01 00:00:00

abstract：:A new technique to obstruct the pancreatic ducts was developed by injecting zein solution into the common bile duct of the rat. Four weeks after the injection, the fate of the endocrine pancreas was investigated by studying (a) pancreatic content of four pancreatic hormones, (b) histology and immunohistochemistry of t...

journal_title：Pancreas

authors： Tomita T,Rhodes J,Falscroft J,Doull V,Kimmel JR,Pollock HG

更新日期：1988-01-01 00:00:00

abstract：:To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...

journal_title：Pancreas

authors： Banks PA,Gerzof SG,Chong FK,Worthington MG,Doos WG,Sullivan JG,Johnson WC

更新日期：1990-05-01 00:00:00

abstract：:Peptide YY (PYY) is a recently isolated gut peptide that is found primarily in the mucosal endocrine cells of the terminal ileum, colon, and rectum of several mammalian species, including humans. The purpose of this study was to characterize the effect of PYY on pancreatic exocrine secretion in six conscious dogs prep...

journal_title：Pancreas

authors： Lluis F,Gomez G,Fujimura M,Greeley GH Jr,Thompson JC

更新日期：1987-01-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...

journal_title：Pancreas

authors： Jo JH,Chung MJ,Park JY,Bang S,Park SW,Chung JB,Song SY

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...

journal_title：Pancreas

authors： Pierzynowski SG,Sharma P,Sobczyk J,Garwacki S,Barej W,Weström B

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...

journal_title：Pancreas

authors： Yasuda T,Ueda T,Takeyama Y,Shinzeki M,Sawa H,Nakajima T,Ajiki T,Fujino Y,Suzuki Y,Kuroda Y

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...

journal_title：Pancreas

authors： Gangi A,Malafa M,Klapman J

更新日期：2018-05-01 00:00:00

abstract：:To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...

journal_title：Pancreas

authors： Konturek SJ,Bielański W,Kwiecień N,Konturek J,Czarnobilski K

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) are at a higher risk of developing post-ERCP pancreatitis than patients undergoing diagnostic ERCP. The aim of this study was to evaluate the effectiveness of somatostatin in preventing post-therapeutic ERCP pancreatitis. ...

journal_title：Pancreas

authors： Lee KT,Lee DH,Yoo BM

更新日期：2008-11-01 00:00:00

abstract：:Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...

journal_title：Pancreas

authors： Dunning BE,Ahrén B

更新日期：1992-01-01 00:00:00

abstract：:To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...

journal_title：Pancreas

authors： Lee YL,Kwon HY,Park HS,Lee TH,Park HJ

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...

journal_title：Pancreas

authors： Maehira H,Iida H,Mori H,Kitamura N,Miyake T,Shimizu T,Tani M

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...

journal_title：Pancreas

authors： Shimizu K,Tahara J,Takayama Y,Akao J,Ajihara T,Nagao K,Shiratori K,Tokushige K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

journal_title：Pancreas

authors： Jia D,Taguchi M,Otsuki M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...

journal_title：Pancreas

authors： Hsiao JY,Wang CL,Hsia PJ,Hsieh MC,Hsin SC,Lin KD,Shin SJ

更新日期：2007-11-01 00:00:00

abstract：:In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...

journal_title：Pancreas

authors： Hadac EM,Ghanekar DV,Holicky EL,Pinon DI,Dougherty RW,Miller LJ

更新日期：1996-08-01 00:00:00

abstract：:Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on ...

journal_title：Pancreas

authors： Pandol SJ,Gukovsky I,Satoh A,Lugea A,Gukovskaya AS

更新日期：2003-11-01 00:00:00