Abstract:
:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were treated with normal saline, the NO-synthase substrate L-arginine, the NO donor S-nitroso-N-acetylpenicillamine, aminoguanidine, which is a more powerful inhibitor of inducible NO synthase (iNOS) than is endothelial NO synthase (eNOS), and N-nitro-L-arginine methyl ester (L-NAME), a more powerful inhibitor of eNOS than of iNOS. All drugs were infused intravenously during a period of 6 or 12 h in each group. Pancreatic tissue was removed at 6 and 12 h after creating the CDL. L-Arginine, S-nitroso-N-acetyl-penicillamine, and aminoguanidine treatment had no effect on the elevation of serum pancreatic enzymes, whereas L-NAME administration significantly exacerbated their elevation. Pathologically, L-NAME treatment resulted in a significantly worse histologic score at 6 and 12 h, especially in terms of the degree of hemorrhage, acinar cell necrosis, and microvascular thrombosis. Addition of L-arginine clearly reversed the effect of L-NAME. Neither the NO substrate nor NO donor could inhibit the progression of hemorrhagic pancreatitis in CDL-induced pancreatitis. Aminoguanidine had no effect on the severity of the pancreatitis. We therefore concluded that NO production by eNOS may play a significant role in preventing the development and progression of acute pancreatitis.
journal_name
Pancreasjournal_title
Pancreasauthors
Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi Mdoi
10.1097/00006676-199911000-00011subject
Has Abstractpub_date
1999-11-01 00:00:00pages
390-400issue
4eissn
0885-3177issn
1536-4828journal_volume
19pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001496
更新日期:2020-03-01 00:00:00
abstract::Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199001000-00007
更新日期:1990-01-01 00:00:00
abstract::The secretin stimulation test is the most sensitive and specific test for pancreatic function. It is usually performed using biologically derived porcine secretin. Several shortages of biologic porcine secretin have occurred in the past few years. The aim of this study was to compare synthetic porcine secretin to biol...
journal_title:Pancreas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006676-200010000-00007
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200304000-00007
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181da0f3e
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Prognostic value of histological subtypes of pancreatic intraductal papillary mucinous neoplasm (IPMN) has been reported to have conflicting results. The authors investigated the clinicopathological characteristics and prognostic significance of the histological subtypes of IPMNs with various degrees of dysp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31827cddbc
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236735.39241.d0
更新日期:2006-10-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199805000-00006
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000085
更新日期:2014-07-01 00:00:00
abstract::We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both se...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00005
更新日期:1998-04-01 00:00:00
abstract::Conscious rats were infused with optimal doses of secretin (16 clinical units [CU]/kg/h), cerulein (0.25 microgram/kg/h), and both for varying periods of time over 24 h. The presence of zymogen granules in acinar cells and the tissue content of enzymes showed progressive decreases over 3 and 12 h for cerulein and secr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198611000-00010
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate whether the previously described differentiating islet-like aggregates of human pancreatic adenocarcinoma cells (PANC-1) develop glucose response and exhibit intercellular communication. METHODS:Fura 2-loaded PANC-1 cells in serum-free medium were assayed for changes in cytoso...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182277e56
更新日期:2012-03-01 00:00:00
abstract::In a previous retrospective case-control study, hemoconcentration was associated with the development of pancreatic necrosis. The aim of the present study was to determine in a cohort study whether hemoconcentration is a marker for both organ failure and necrotizing pancreatitis. A cohort study was performed on patien...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200005000-00005
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:Pancreatic stellate cells (PSCs) are important players in pancreatic fibrosis and are major contributors to the extracellular matrix proteins observed with the stromal response characteristic of pancreatic ductal adenocarcinoma (PDAC). Pancreatic stellate cells are also believed to secrete soluble factors tha...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318214efaf
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraducta...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001002
更新日期:2018-03-01 00:00:00
abstract::Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Co...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199701000-00001
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract::Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00015
更新日期:1994-01-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF alpha) has been implicated as one of the numerous likely mediators of the systemic complications of acute pancreatitis. Recent suggestions that calcium (Ca2+) acts as a signal not only for TNF alpha release but also for TNF alpha action at distant sites led us to hypothesize that the c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199607000-00003
更新日期:1996-07-01 00:00:00
abstract:INTRODUCTION:Severe acute pancreatitis (SAP) remains a serious disease state difficult to manage. Laparoscopic surgery represents a relatively new solution to this problem. This study was aimed to investigate the feasibility of laparoscopic treatment of SAP and the selection of laparoscopic procedures in various stages...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200310000-00019
更新日期:2003-10-01 00:00:00
abstract::In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00012
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e318160a5e2
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0b013e3182557c24
更新日期:2013-01-01 00:00:00
abstract::250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00008
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000001225
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182a85e1e
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The risk of adverse effects of dipeptidyl peptidase-4 inhibitors on the exocrine pancreas, particularly the high risk of pancreatitis, is controversial. In this study, we examined the exocrine pancreatic function and structure in spontaneously diabetic Goto-Kakizaki (GK) rats treated with a dipeptidyl peptid...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318287c9b5
更新日期:2013-07-01 00:00:00
abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199311000-00010
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS:MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measure...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31815929fe
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000001016
更新日期:2018-04-01 00:00:00