Abstract:
:Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Committee for Intractable Diseases of the Pancreas, Japanese Ministry of Health and Welfare (1990). To evaluate markers for early estimation of the severity of acute pancreatitis, we measured serum changes in various parameters. In the severe group interleukin-6 (IL-6) levels were increased significantly 5, 24, 72, and 120 h after the onset (p < 0.01), compared with the mild group. C-reactive protein (CRP), thrombin antithrombin III, and alpha 2-plasmin inhibitor plasmin complex levels were significantly increased only at the 72-h time point. Peak values of interleukin-8 (IL-8) and soluble human E selectin were observed at 5 and 72 h, respectively, after the onset. There was a significant correlation between IL-6 at 5 h and both pancreatic secretory trypsin inhibitor (r = 0.85) and CRP (r = 0.94) at 72 h. We therefore conclude that IL-6 is a useful marker for assessment of the severity of acute pancreatitis in its early stages.
journal_name
Pancreasjournal_title
Pancreasauthors
Inagaki T,Hoshino M,Hayakawa T,Ohara H,Yamada T,Yamada H,Iida M,Nakazawa T,Ogasawara T,Uchida A,Hasegawa C,Miyaji M,Takeuchi Tdoi
10.1097/00006676-199701000-00001subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1-8issue
1eissn
0885-3177issn
1536-4828journal_volume
14pub_type
杂志文章相关文献
PANCREAS文献大全abstract::The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000179727.15716.82
更新日期:2005-11-01 00:00:00
abstract::We diverted bile and pancreatic juice from jejunal blind loops of different lengths in conscious rats to see if the pancreatic secretory response was dependent on the length of the jejunal blind loop. Short-term bile and pancreatic juice diversion from a short jejunal blind loop, representing only 8-10% of the total l...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199901000-00007
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000000475
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by othe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000758
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution to...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001272
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000334
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:Prognostic value of histological subtypes of pancreatic intraductal papillary mucinous neoplasm (IPMN) has been reported to have conflicting results. The authors investigated the clinicopathological characteristics and prognostic significance of the histological subtypes of IPMNs with various degrees of dysp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31827cddbc
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000685
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:It is of utmost importance that autoimmune pancreatitis (AIP) be differentiated from pancreatic cancer (PC) because some AIP cases undergo unnecessary laparotomy or pancreatic resection on suspicion of PC. This study aimed to develop an appropriate strategy for differentiating between AIP and PC. METHODS:Cl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318175e3a0
更新日期:2008-10-01 00:00:00
abstract:UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181f95104
更新日期:2011-03-01 00:00:00
abstract::Protein phosphatases have recently been recognized to represent an important, independently regulated portion of cellular signaling cascades. Although reversible phosphorylation of multiple pancreatic proteins has been described, suggesting a role for these enzymes, little is known about the characteristics of protein...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199407000-00002
更新日期:1994-07-01 00:00:00
abstract::Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199801000-00006
更新日期:1998-01-01 00:00:00
abstract::Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198802000-00007
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000406
更新日期:2015-10-01 00:00:00
abstract::Pancreatic carcinoma is one of the most devastating neoplasms with regard to its resistance to conventional therapy. In a previous report, we found that endogenous tumor necrosis factor (enTNF) exerts an intracellular protective effect against exogenous TNF- and Adriamycin (ADM)-induced cytotoxicity by scavenging oxyg...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199611000-00009
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182649979
更新日期:2013-03-01 00:00:00
abstract::In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00012
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182847a86
更新日期:2013-10-01 00:00:00
abstract::Several reports have described a loss of endogenous antioxidants and molecular oxidative damage during acute pancreatitis. Since hyaluronic acid and chondroitin-4-sulfate possess antioxidant properties, the effect of the administration of these glycosaminoglycans in a cerulein-induced acute pancreatitis in rats was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00019
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:Survivin, an antiapoptotic gene inhibited by p53, is overexpressed in human cancers and correlates with chemotherapy resistance. Here, we investigated the mutual regulatory mechanism between MGMT (O-methylguanine DNA methyltransferase) and survivin. METHODS:This study used standard techniques for protein an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000299
更新日期:2015-05-01 00:00:00
abstract:UNLABELLED:Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. METHODS:: In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31816fd7b6
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31823ba75a
更新日期:2012-07-01 00:00:00
abstract::High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the cl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001171
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To investigate the antitumor activity of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus S-1 in patient-derived pancreatic cancer xenograft mouse models and to explore biomarkers that could predict drug efficacy. METHODS:Ten patient-derived xenograft models were established. The third-generation...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000501
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000072
更新日期:2014-05-01 00:00:00
abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00004
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000163
更新日期:2014-10-01 00:00:00
abstract::A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-198802000-00020
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001505
更新日期:2020-03-01 00:00:00