A minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma using biomarkers in duodenal juice.

abstract：OBJECTIVES:Serum pancreastatin is a sensitive and specific diagnostic biomarker in neuroendocrine tumors (NETs). Elevated pancreastatin levels are associated with worse progression-free survival and overall survival in small bowel and pancreatic NETs. In this study, we investigated the clinical significance of elevated...

journal_title：Pancreas

authors： Khan TM,Garg M,Warner RR,Uhr JH,Divino CM

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...

journal_title：Pancreas

authors： Bayan JA,Peng Z,Zeng N,He L,Chen J,Stiles BL

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...

journal_title：Pancreas

authors： Inui K,Masamune A,Igarashi Y,Ohara H,Tazuma S,Sugiyama M,Suzuki Y,Miyoshi H,Yamamoto S,Takeyama Y,Nakano E,Takuma K,Sakagami J,Hayashi K,Kogure A,Ito T,Mukai T,Maetani I,Nagahama M,Serikawa M,Ueki T,Furuya K,I

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...

journal_title：Pancreas

authors： Kudo M,Kobayashi T,Gotohda N,Konishi M,Takahashi S,Kobayashi S,Sugimoto M,Okubo S,Martin J,Cabral H,Ishii G,Kojima M

更新日期：2020-05-01 00:00:00

abstract：:The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...

journal_title：Pancreas

authors： Cavallini G,Talamini G,Vaona B,Bovo P,Filippini M,Rigo L,Angelini G,Vantini I,Riela A,Frulloni L

更新日期：1994-01-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...

journal_title：Pancreas

authors： Wang H,Xiu D,Jiang B,Ma C,Yuan C

更新日期：2014-05-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Jou TS,Tai TY,Lin BJ

更新日期：1992-01-01 00:00:00

abstract：:We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...

journal_title：Pancreas

authors： Kimura Y,Hirota M,Okabe A,Inoue K,Kuwata K,Ohmuraya M,Ogawa M

更新日期：2003-08-01 00:00:00

abstract：:Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...

journal_title：Pancreas

authors： Roza AM,Pieper GM,Johnson CP,Adams MB

更新日期：1995-01-01 00:00:00

abstract：:Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...

journal_title：Pancreas

authors： Lukás Z,Dvorák K,Kroupová I,Valásková I,Habanec B

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Activation of "nicotinic anti-inflammatory pathway" could reduce severity of inflammation and injury induced by acute pancreatitis. However, the role of regulatory T (Treg) cells in this pathway is unclear. METHODS:Severe acute pancreatitis (SAP) was induced in mice through retrograde injection of 50-μL 2% ...

journal_title：Pancreas

authors： Zheng YS,Wu ZS,Zhang LY,Ke L,Li WQ,Li N,Li JS

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed...

journal_title：Pancreas

authors： Dežman R,Čemažar M,Serša G,Seliškar A,Erjavec V,Trotovšek B,Gašljevič G,Bošnjak M,Lampreht Tratar U,Kos B,Djokić M,Milevoj N,Štukelj M,Boc N,Izlakar J,Popovič P

更新日期：2020-10-01 00:00:00

abstract：:Dogs with chronic pancreatic fistulae were given 0.5 ml of nonimmune rabbit serum or antibody S5, an antibody raised against the C-terminal pancreatic polypeptide (PP) hexapeptide. A 3-h infusion of secretin (125 ng/kg/h) and CCK8 (50 ng/kg/h) was started 30 min after injecting serum. Exogenous BPP (400 pmol/kg/h) was...

journal_title：Pancreas

authors： Fink AS,Gilbert S,Green H,Taylor IL

更新日期：1987-01-01 00:00:00

abstract：:Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...

journal_title：Pancreas

authors： Göke B,Keim V,Dagorn JC,Arnold R,Adler G

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a usef...

journal_title：Pancreas

authors： Lipinski M,Rydzewska-Rosolowska A,Rydzewski A,Rydzewska G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS:MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measure...

journal_title：Pancreas

authors： Baker AF,Koh MY,Williams RR,James B,Wang H,Tate WR,Gallegos A,Von Hoff DD,Han H,Powis G

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...

journal_title：Pancreas

authors： Li Y,Li G,Dong W,Chen J,Lu D,Tan J

更新日期：2006-10-01 00:00:00

abstract：:140 patients with alcoholic acute (recurrent) pancreatitis were enrolled in a prospective long-term study over the last 16 years. Regular control studies regarding progression to advanced chronic pancreatitis were performed. Based on long-term outcome the patients were classified into two groups: group A (n = 109; 77....

journal_title：Pancreas

authors： Ammann RW,Muellhaupt B,Meyenberger C,Heitz PU

更新日期：1994-05-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：:It was reported that free fatty acids degraded from triglycerides by lipase may play a major role in acute necrotizing or hyperlipidemia-induced pancreatitis. We hypothesized that this injury may be related to the peroxidation of cell membrane phospholipids and tested this hypothesis using isolated pancreatic acini. P...

journal_title：Pancreas

authors： Morita Y,Yoshikawa T,Takeda S,Matsuyama K,Takahashi S,Yoshida N,Clemens MG,Kondo M

更新日期：1998-11-01 00:00:00

abstract：:Stimulation of the exocrine pancreas is one of the biological effects attributed to the tridecapeptide neurotensin (NT). Only the C-terminal 8-13 fragment with its extremely short plasma half-life in the peripheral circulation was considered to be necessary for biological activity. The N-terminal fragments that are de...

journal_title：Pancreas

authors： Nustede R,Köhler H,Pfannkuche A,Fölsch UR,Schafmayer A

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...

journal_title：Pancreas

authors： Choi J,Wang J,Ren G,Thakor AS

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...

journal_title：Pancreas

authors： Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：:We have studied the degree of pancreatic secretory alterations assessed by secretin-cerulein test (S-C) in relation to various morphological changes detected by real-time ultrasonography (US) in 42 patients affected by chronic pancreatitis. Exocrine insufficiency was found in 41 patients (97.6%), while morphological a...

journal_title：Pancreas

authors： Bolondi L,Priori P,Gullo L,Santi V,Li Bassi S,Barbara L,Labó G

更新日期：1987-01-01 00:00:00

abstract：:The recent publication of evidence-based guidelines by the American Gastroenterological Association for the management of the incidental pancreatic cyst has stimulated considerable discussion among clinicians and researchers. The guidelines examined the evidence in an accompanying technical review defining current dia...

journal_title：Pancreas

authors： Scheiman JM

更新日期：2017-07-01 00:00:00

abstract：:The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to disc...

journal_title：Pancreas

authors： Brunicardi FC,Mullen Y

更新日期：1994-05-01 00:00:00

abstract：:In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...

journal_title：Pancreas

authors： Hadac EM,Ghanekar DV,Holicky EL,Pinon DI,Dougherty RW,Miller LJ

更新日期：1996-08-01 00:00:00