The biological relevance of N-terminal neurotensin fragments in the regulation of exocrine pancreas secretion.

abstract：INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...

journal_title：Pancreas

authors： Park HS,Yoon HS,Park YD,Cui ZY,Lee YL,Park HJ

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...

journal_title：Pancreas

authors： Bashaw H,Brownell JN,Schall JI,Stallings VA

更新日期：2020-07-01 00:00:00

abstract：METHODOLOGY:The authors performed the reverse transcription-polymerase chain reaction (RT-PCR) in 17 cases of pancreatic ductal cell carcinoma (PDC) and five cases of normal pancreatic tissues to determine the expression of tumor necrosis factor -related apoptosis-inducing factor (TRAIL) and its five receptors in PDC. ...

journal_title：Pancreas

authors： Satoh K,Kaneko K,Hirota M,Masamune A,Satoh A,Shimosegawa T

更新日期：2001-10-01 00:00:00

abstract：:In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...

journal_title：Pancreas

authors： Merisko EM,Farquhar MG,Palade GE

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...

journal_title：Pancreas

authors： Mitnala S,Pondugala PK,Guduru VR,Rabella P,Thiyyari J,Chivukula S,Boddupalli S,Hardikar AA,Reddy DN

更新日期：2010-08-01 00:00:00

abstract：:The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...

journal_title：Pancreas

authors： Duan RD,Erlanson-Albertsson C

更新日期：1990-03-01 00:00:00

abstract：:Wheat amylase inhibitor (WAI) was given to growing rats to determine whether chronic inhibition of intraluminal amylase activity alters pancreatic growth, pancreatic enzyme composition, and secretory responsiveness to cholecystokinin octapeptide (CCK-OP) and carbachol. For 21 days 13 rats were fed amylase inhibitor (A...

journal_title：Pancreas

authors： Kataoka K,DiMagno EP

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...

journal_title：Pancreas

authors： Satoi S,Toyokawa H,Yanagimoto H,Yamamoto T,Hirooka S,Yui R,Yamaki S,Takahashi K,Matsui Y,Mergental H,Kwon AH

更新日期：2010-03-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：:Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,El-Metwally T,Moyer MP,Ricordi C,Adrian TE,Batra SK,Pour PM

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft. METHODS:Isolated rat islets were encapsulated in an inner core made with 1.5% low-viscos...

journal_title：Pancreas

authors： Pareta R,McQuilling JP,Sittadjody S,Jenkins R,Bowden S,Orlando G,Farney AC,Brey EM,Opara EC

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal tr...

journal_title：Pancreas

authors： De Waele E,Wauters E,Ling Z,Bouwens L

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...

journal_title：Pancreas

authors： Ostenson CG,Chen J,Sheu L,Gaisano HY

更新日期：2007-04-01 00:00:00

abstract：:A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...

journal_title：Pancreas

authors： Iwai K,Fushiki T,Fukuoka S

更新日期：1988-01-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS:A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 ...

journal_title：Pancreas

authors： Philips P,Kooby DA,Maithel S,Merchant NB,Weber SM,Winslow ER,Ahmad S,Kim HJ,Scoggins CR,McMasters KM,Martin RCG 2nd

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...

journal_title：Pancreas

authors： Sell NM,Lee GC,Fernández-Del Castillo C,Ferrone CR,Warshaw AL,Hong TS,Blaszkowsky LS,Lillemoe KD,Qadan M

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To establish new biomarkers for accurate diagnosis of pancreatic cancer (PC) using a standardized serum peptidome profiling and compare the results with those from the tumor marker, CA 19-9. METHODS:Serum samples from 102 patients (55 with chronic pancreatitis and 47 with PC) and 56 healthy controls were col...

journal_title：Pancreas

authors： Zapico-Muñiz E,Farré-Viladrich A,Rico-Santana N,González-Sastre F,Mora-Brugués J

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma oc...

journal_title：Pancreas

authors： Woltering EA,Salvo VA,O'Dorisio TM,Lyons J 3rd,Li G,Zhou Y,Seward JR,Go VL,Vinik AI,Mamikunian P,Mamikunian G

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Pancreatic anastomotic leakage remains a major troublesome complication after pancreaticoduodenectomy. Thus, various technical modifications regarding the pancreatic anastomosis after pancreaticoduodenectomy have been attempted to minimize anastomotic leakage. We have performed duct-to-mucosa pancreaticojeju...

journal_title：Pancreas

authors： Hayashibe A,Kameyama M

更新日期：2007-10-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：:Pancreatic cystic insulinoma is an uncommon tumor. Perioperative localization remained challenging if the tumor is atypical with cystic feature or in small size. Near-infrared (NIR) imaging is a technique by injecting fluorescent dye intravenously, which accumulates to the target lesion and creating signal by laser so...

journal_title：Pancreas

authors： Kou HW,Yu MC,Chong SW,Hsu HY,Chou HH,Lee CW,Chen TC,Huang SF

更新日期：2020-11-01 00:00:00

abstract：:High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the cl...

journal_title：Pancreas

authors： Fisher WE,Cruz-Monserrate Z,McElhany AL,Lesinski GB,Hart PA,Ghosh R,Van Buren G,Fishman DS,Rinaudo JAS,Serrano J,Srivastava S,Mace T,Topazian M,Feng Z,Yadav D,Pandol SJ,Hughes SJ,Liu RY,Lu E,Orr R,Whitcomb DC,Ab

更新日期：2018-11-01 00:00:00

abstract：:Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...

journal_title：Pancreas

authors： Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

更新日期：1994-03-01 00:00:00

abstract：:The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...

journal_title：Pancreas

authors： Friess H,Malfertheiner P,Isenmann R,Kühne H,Beger HG,Büchler MW

更新日期：1996-08-01 00:00:00

abstract：:The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...

journal_title：Pancreas

authors： Saydjari R,Alexander RW,Barranco SC,Townsend CM Jr,Thompson JC

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...

journal_title：Pancreas

authors： Gardner TB,Taylor DJ,Gordon SR

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...

journal_title：Pancreas

authors： Singh P,Srinivasan R,Wig JD

更新日期：2012-05-01 00:00:00

abstract：:Neonatal rats treated with streptozotocin on day 5 after birth (n5-STZ model) exhibited, when fully grown, a frank basal hyperglycemia (17.4 +/- 0.7 vs. 6.6 +/- 0.2 mmol/L in nondiabetic rats), a specific failure of glucose-induced insulin release, and hyperresponse to arginine. To investigate whether or not chronic c...

journal_title：Pancreas

authors： Serradas P,Bailbé D,Blondel O,Portha B

更新日期：1991-01-01 00:00:00