Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer.

abstract：:We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...

journal_title：Pancreas

authors： Yamaguchi Y,Matsumura F,Liang J,Okabe K,Matsuda T,Ohshiro H,Ishihara K,Akizuki E,Yamada S,Ogawa M

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...

journal_title：Pancreas

authors： Majumder S,Gierisch JM,Bastian LA

更新日期：2015-05-01 00:00:00

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00

abstract：:The clinical, diagnostic, and therapeutic aspects of 27 patients with pancreatopleural fistula (PPF) reported in the literature, and two additional patients managed by the authors, form the basis of this report. The diagnosis of PPF is based on the triad of massive pleural effusions, elevated pleural fluid amylase, an...

journal_title：Pancreas

authors： Bedingfield JA,Anderson MC

更新日期：1986-01-01 00:00:00

abstract：:Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...

journal_title：Pancreas

authors： Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...

journal_title：Pancreas

authors： Tian Y,Xue Y,Ruan G,Cheng K,Tian J,Qiu Q,Xiao M,Li H,Yang H,Wang L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer. METHODS:We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 pati...

journal_title：Pancreas

authors： Niu L,Chen J,He L,Liao M,Yuan Y,Zeng J,Li J,Zuo J,Xu K

更新日期：2013-10-01 00:00:00

abstract：:We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Tsai WY,Lai CS,Tai TY,Lin BJ

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:Nuclear factor κB (NF-κB) plays an intrinsic role in promoting growth, angiogenesis, and metastasis in pancreatic cancer (PC) and serves as a mechanism underlying therapeutic resistance. Accordingly, we investigated the efficacy of bioactive phytochemicals in inhibiting radiotherapy (RT)-induced NF-κB activi...

journal_title：Pancreas

authors： Veeraraghavan J,Natarajan M,Lagisetty P,Awasthi V,Herman TS,Aravindan N

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...

journal_title：Pancreas

authors： Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

更新日期：2014-04-01 00:00:00

abstract：:The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...

journal_title：Pancreas

authors： Hackert T,Klaiber U,Pausch T,Mihaljevic AL,Büchler MW

更新日期：2020-09-01 00:00:00

abstract：:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...

journal_title：Pancreas

authors： Morioka CY,Saito S,Ohzawa K,Watanabe A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Previously reported data suggest that serum leptin concentration changes in some acute and chronic inflammatory diseases. The aim of the present study was to assess serum leptin concentration in patients with chronic pancreatitis. METHODS:Forty-four male patients with chronic pancreatitis and 16 healthy (mal...

journal_title：Pancreas

authors： Adrych K,Smoczynski M,Goyke E,Stelmanska E,Swierczynski J

更新日期：2007-05-01 00:00:00

abstract：:A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...

journal_title：Pancreas

authors： Iwai K,Fushiki T,Fukuoka S

更新日期：1988-01-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...

journal_title：Pancreas

authors： Arita Y,Kimura T,Ogami Y,Nawata H

更新日期：1991-01-01 00:00:00

abstract：:Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive ja...

journal_title：Pancreas

authors： Estrella JS,Wang H,Bhosale PR,Evans HL,Abraham SC

更新日期：2015-08-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:To investigate embryology of complete and incomplete pancreas divisum (PD). METHODS:We analyzed anatomy of the pancreatic duct system in 44 cases of complete PD and 41 cases of incomplete PD. Under the concept of branch fusion between the ventral and dorsal pancreatic ducts, incomplete PD was divided into 3...

journal_title：Pancreas

authors： Kamisawa T,Egawa N,Tu Y,Tsuruta K,Okamoto A

更新日期：2007-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...

journal_title：Pancreas

authors： Jamal H,Suda K,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...

journal_title：Pancreas

authors： Marabita F,Islam MS

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...

journal_title：Pancreas

authors： Ramudo L,Yubero S,Manso MA,Sanchez-Recio J,Weruaga E,De Dios I

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...

journal_title：Pancreas

authors： Lin Y,Kikuchi S,Tamakoshi A,Yagyu K,Obata Y,Kurosawa M,Inaba Y,Kawamura T,Motohashi Y,Ishibashi T,JACC Study Group.

更新日期：2008-07-01 00:00:00

abstract：:We diverted bile and pancreatic juice from jejunal blind loops of different lengths in conscious rats to see if the pancreatic secretory response was dependent on the length of the jejunal blind loop. Short-term bile and pancreatic juice diversion from a short jejunal blind loop, representing only 8-10% of the total l...

journal_title：Pancreas

authors： Spannagel AW,Green GM

更新日期：1999-01-01 00:00:00

abstract：:To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...

journal_title：Pancreas

authors： Kairaluoma MI,Kiviniemi H,Laitinen S,Ståhlberg M

更新日期：1987-01-01 00:00:00

abstract：:The secretin stimulation test is the most sensitive and specific test for pancreatic function. It is usually performed using biologically derived porcine secretin. Several shortages of biologic porcine secretin have occurred in the past few years. The aim of this study was to compare synthetic porcine secretin to biol...

journal_title：Pancreas

authors： Somogyi L,Cintron M,Toskes PP

更新日期：2000-10-01 00:00:00

abstract：:Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...

journal_title：Pancreas

authors： Berry SM,Fink AS

更新日期：1996-05-01 00:00:00

abstract：:Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...

journal_title：Pancreas

authors： Takaya H,Andoh A,Shimada M,Hata K,Fujiyama Y,Bamba T

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...

journal_title：Pancreas

authors： Schöffel N,Krempel M,Bundschuh M,Bendels MH,Brüggmann D,Groneberg DA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...

journal_title：Pancreas

authors： Cizginer S,Turner BG,Bilge AR,Karaca C,Pitman MB,Brugge WR

更新日期：2011-10-01 00:00:00