Abstract:
:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression of the disease. This finding prompted us to look for a similar pattern in patients with obstructive acute pancreatitis due to biliary stones. Forty-two patients with biliary acute pancreatitis were prospectively studied. Twenty-one patients underwent urgent endoscopic sphincterotomy (ES), and 21 received conservative medical treatment (CMT). The two groups were comparable for sex, age, onset of pain, and severity. Serum amylase and lipase were determined in all patients on admission and 24 h later. The percentage variation of serum amylase and lipase was calculated considering, for each patient, the concentrations of the two enzymes assayed on admission and 24 h later. On admission, all patients had elevated serum concentrations of amylase (mean +/- SEM: ES, 2,560+/-473 U/L; CMT, 1,783+/-481 U/L) and lipase (ES, 3,037+/-574 U/L; CMT, 3,179+/-724 U/L). The serum amylase variation (mean +/- SEM) was -65.6+/-5.5% in the ES and -47.2.1+/-8.1% in the CMT patients. The serum lipase variation was -59.1+/-7.7 and -33.1+/-18% in the same groups, respectively. These differences were not statistically significant. Acute pancreatitis worsened in one patient in the ES group and in seven in the CMT group; this difference was statistically significant (p < 0.02). The mean length of hospitalization was 8.9 days in the ES group and 19.7 days in the CMT group (p < 0.001). Serum pancreatic enzymes determination is not useful to evaluate the results of the early decompression of biliary duct in human acute pancreatitis. Indeed, early endoscopic sphincterotomy may result in a substantial improvement in the outcome of biliary acute pancreatitis.
journal_name
Pancreasjournal_title
Pancreasauthors
Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio Fdoi
10.1097/00006676-199803000-00010subject
Has Abstractpub_date
1998-03-01 00:00:00pages
165-8issue
2eissn
0885-3177issn
1536-4828journal_volume
16pub_type
杂志文章相关文献
PANCREAS文献大全abstract:UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3181f95104
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:A selective therapy for pancreatitis is total pancreatectomy and islet autotransplantation. Outcomes and geographical variability of patients who had total pancreatectomy (TP) alone or total pancreatectomy with islet autotransplantation (TPIAT) were assessed. METHODS:Data were obtained from the Healthcare C...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001405
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000199
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180304825
更新日期:2007-04-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000150
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas include neoplasms with varying likelihood of progression to malignancy. The aim of this study was to investigate a natural course of main duct IPMNs with a lower likelihood of malignancy. METHODS:Twenty main duct IPMNs with a lower l...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c81b52
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001606
更新日期:2020-08-01 00:00:00
abstract::This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199003000-00008
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001682
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001142
更新日期:2018-10-01 00:00:00
abstract::Wheat amylase inhibitor (WAI) was given to growing rats to determine whether chronic inhibition of intraluminal amylase activity alters pancreatic growth, pancreatic enzyme composition, and secretory responsiveness to cholecystokinin octapeptide (CCK-OP) and carbachol. For 21 days 13 rats were fed amylase inhibitor (A...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199807000-00006
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraducta...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001002
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000431
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000633
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153336.50482.59
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001434
更新日期:2019-11-01 00:00:00
abstract::The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000001203
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200208000-00019
更新日期:2002-08-01 00:00:00
abstract::Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00011
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182a85e1e
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001229
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000434
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200205000-00008
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:Association between acute pancreatitis and acute viral hepatitis (AVH) is more frequent than previously thought. Most cases are hepatitis A or B virus related. Only 6 cases of acute pancreatitis with acute hepatitis E virus (HEV)-related hepatitis has been reported so far. METHODS:We analyzed the hospital r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31815d9d53
更新日期:2008-05-01 00:00:00
abstract::The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199101000-00015
更新日期:1991-01-01 00:00:00
abstract::Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199105000-00014
更新日期:1991-05-01 00:00:00
abstract::The aim of this study was to document the natural history of chronic hereditary pancreatitis and to compare its evolution to that of chronic alcoholic pancreatitis. Twelve subjects with chronic hereditary pancreatitis were followed up for a mean duration of 15.8 years (range, 1-23) and compared to subjects with chroni...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199810000-00007
更新日期:1998-10-01 00:00:00