Crosstalk Between Activated Myofibroblasts and β Cells in Injured Mouse Pancreas.

abstract：:The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...

journal_title：Pancreas

authors： Hackert T,Klaiber U,Pausch T,Mihaljevic AL,Büchler MW

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Activation of "nicotinic anti-inflammatory pathway" could reduce severity of inflammation and injury induced by acute pancreatitis. However, the role of regulatory T (Treg) cells in this pathway is unclear. METHODS:Severe acute pancreatitis (SAP) was induced in mice through retrograde injection of 50-μL 2% ...

journal_title：Pancreas

authors： Zheng YS,Wu ZS,Zhang LY,Ke L,Li WQ,Li N,Li JS

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Treatment of the pain caused by chronic pancreatitis (CP) is not standardized. Knowledge of the response to placebo in this setting may aid the design of future trials. We aimed at investigating the placebo effect on abdominal pain remission rates in patients with CP. METHODS:MEDLINE, EMBASE, and Scopus wer...

journal_title：Pancreas

authors： Capurso G,Cocomello L,Benedetto U,Cammà C,Delle Fave G

更新日期：2012-10-01 00:00:00

abstract：:Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...

journal_title：Pancreas

authors： Wu F,Jagir M,Powell JS

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：INTRODUCTION:The role of melatonin in human insulin regulation is poorly understood. AIM:To investigate the influence of melatonin supplementation on glucose and insulin levels and on lipid metabolism in blood serum and the liver. METHODOLOGY:The acute melatonin effects on insulin secretion in male Wistar rats were i...

journal_title：Pancreas

authors： Fabiś M,Pruszyńska E,Maćkowiak P

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...

journal_title：Pancreas

authors： Bashaw H,Brownell JN,Schall JI,Stallings VA

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...

journal_title：Pancreas

authors： Coppola D,Helm J,Ghayouri M,Malafa MP,Wang HG

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...

journal_title：Pancreas

authors： Yasuda T,Ueda T,Takeyama Y,Shinzeki M,Sawa H,Nakajima T,Ajiki T,Fujino Y,Suzuki Y,Kuroda Y

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To establish new biomarkers for accurate diagnosis of pancreatic cancer (PC) using a standardized serum peptidome profiling and compare the results with those from the tumor marker, CA 19-9. METHODS:Serum samples from 102 patients (55 with chronic pancreatitis and 47 with PC) and 56 healthy controls were col...

journal_title：Pancreas

authors： Zapico-Muñiz E,Farré-Viladrich A,Rico-Santana N,González-Sastre F,Mora-Brugués J

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...

journal_title：Pancreas

authors： Karabatas LM,Pastorale C,de Bruno LF,Maschi F,Pivetta OH,Lombardo YB,Chemes H,Basabe JC

更新日期：2005-05-01 00:00:00

abstract：:Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...

journal_title：Pancreas

authors： Frantz ED,Peixoto-Silva N,Pinheiro-Mulder A

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...

journal_title：Pancreas

authors： Wakabayashi T,Kawaura Y,Satomura Y,Fujii T,Motoo Y,Okai T,Sawabu N

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...

journal_title：Pancreas

authors： Cavallini G,Talamini G,Vaona B,Bovo P,Filippini M,Rigo L,Angelini G,Vantini I,Riela A,Frulloni L

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...

journal_title：Pancreas

authors： Rosenblum RE,Harris CK,Baeg KJ,Starr JA,Brais LK,Stashek KM,Ward SC,Katona BW,Clancy TE,Wisnivesky JP,Kulke MH,Metz DC,Kim MK,Chan JA

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...

journal_title：Pancreas

authors： Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

更新日期：2008-01-01 00:00:00

abstract：:To study the influence of extracellular matrix (ECM) on isolated fetal porcine islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel (MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix for 20 days. The insulin accumulation in the culture medium was determined every fifth...

journal_title：Pancreas

authors： Oberg-Welsh C

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies. METHODS:Data were assessed in 2 dimensions, based on RNA-seq si...

journal_title：Pancreas

authors： Blobner BM,Bellin MD,Beilman GJ,Shelton CA,Park HJ,Whitcomb DC

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Presentation of pancreatic adenocarcinoma (PC) as acute pancreatitis (AP), association of chronic pancreatitis (CP) with PC, and role of inflammation in PC carcinogenesis are well recognized. We hypothesized that inflammatory changes associated with remote history of AP (≥2 years before PC diagnosis) would r...

journal_title：Pancreas

authors： Phillips AE,Shah N,Borhani AA,Yadav D,Brand RE

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...

journal_title：Pancreas

authors： Kitamura T,Asanuma N,Inaba M,Otsuki M,Kasayama S,Kouhara H,Kawase I

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...

journal_title：Pancreas

authors： Borowitz D,Goss CH,Stevens C,Hayes D,Newman L,O'Rourke A,Konstan MW,Wagener J,Moss R,Hendeles L,Orenstein D,Ahrens R,Oermann CM,Aitken ML,Mahl TC,Young KR Jr,Dunitz J,Murray FT

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...

journal_title：Pancreas

authors： Ben Q,An W,Wang L,Wang W,Yu L,Yuan Y

更新日期：2015-04-01 00:00:00

abstract：:Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...

journal_title：Pancreas

authors： De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

更新日期：2003-10-01 00:00:00

abstract：:Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...

journal_title：Pancreas

authors： Roza AM,Pieper GM,Johnson CP,Adams MB

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...

journal_title：Pancreas

authors： Morinville VD,Barmada MM,Lowe ME

更新日期：2010-01-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00