In vivo assessment of lipid peroxidation in experimental edematous and necrotizing rat pancreatitis.

abstract：OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...

journal_title：Pancreas

authors： Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

更新日期：2005-07-01 00:00:00

abstract：:Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...

journal_title：Pancreas

authors： Yokomatsu H,Satake K,Hiura A,Tsutsumi M,Suganuma M

更新日期：1994-07-01 00:00:00

abstract：:A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...

journal_title：Pancreas

authors： Lee WY,Tzeng CC,Jin YT,Chow NH,Yip CM,Lee JC

更新日期：1993-01-01 00:00:00

abstract：:Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled mi...

journal_title：Pancreas

authors： DeMar AR,Graham LS,Lake R,Fink AS

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:The present study describes a simple and cost-effective islet isolation procedure. Using this method, allogeneic islets reverse diabetes in cynomolgus monkeys. METHODS:Pancreatic tissue from 11 cynomolgus monkeys were digested, collected, and purified using a simplified method. Islet quantification, purity,...

journal_title：Pancreas

authors： Qi M,Wang Y,Formo K,Marchese E,Wang S,McGarrigle JJ,Bochenek MA,Kinzer K,Vaca P,Davis M,Ahn SJ,Chang K,Bartholomew A,Benedetti E,Oberholzer J

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...

journal_title：Pancreas

authors： Yang Z,Chen M,Fialkow LB,Ellett JD,Wu R,Nadler JL

更新日期：2003-05-01 00:00:00

abstract：:Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...

journal_title：Pancreas

authors： De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

更新日期：2003-10-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The present study aimed to assess the clinical significance of PXR in pancreatic adenocarcinoma. METHODS:Pregnane X receptor and its...

journal_title：Pancreas

authors： Koutsounas I,Giaginis C,Alexandrou P,Zizi-Serbetzoglou A,Patsouris E,Kouraklis G,Theocharis S

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...

journal_title：Pancreas

authors： Apodaca-Torrez FR,Goldenberg A,Lobo EJ,Farah JF,Triviño T,Montero EF,Schraibman V,Benvenuto RB,Artigiani Neto R

更新日期：2007-11-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...

journal_title：Pancreas

authors： Langlois A,Morisset J

更新日期：1991-09-01 00:00:00

abstract：:Fetal and neonatal pancreatic islets have lower insulin secretory responses compared with adult islets. In culture conditions and after treatment with mammosomatotropic hormones, neonatal islets undergo maturation of the secretory machinery that might involve regulation of cell-cell contacts within the islet. This stu...

journal_title：Pancreas

authors： Collares-Buzato CB,Leite AR,Boschero AC

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...

journal_title：Pancreas

authors： Coppola D,Helm J,Ghayouri M,Malafa MP,Wang HG

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...

journal_title：Pancreas

authors： Marques RG,Fontaine MJ,Rogers J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00

abstract：:We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...

journal_title：Pancreas

authors： Kimura Y,Hirota M,Okabe A,Inoue K,Kuwata K,Ohmuraya M,Ogawa M

更新日期：2003-08-01 00:00:00

abstract：:The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...

journal_title：Pancreas

authors： Friess H,Malfertheiner P,Isenmann R,Kühne H,Beger HG,Büchler MW

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...

journal_title：Pancreas

authors： Bhopale KK,Amer SM,Kaphalia L,Soman KV,Wiktorowicz JE,Shakeel Ansari GA,Kaphalia BS

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...

journal_title：Pancreas

authors： Shea K,Rouse R

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...

journal_title：Pancreas

authors： Morinville VD,Barmada MM,Lowe ME

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...

journal_title：Pancreas

authors： Ostenson CG,Chen J,Sheu L,Gaisano HY

更新日期：2007-04-01 00:00:00

abstract：:Reports of a so-called "mucin-producing tumor of the pancreas" are increasing worldwide. Although the clinicopathologic features and therapeutic strategies of this tumor have been enthusiastically investigated, there are still many unanswered questions regarding this ailment. In this study, problems in the diagnosis a...

journal_title：Pancreas

authors： Kimura W,Kuroda A,Makuuchi M

更新日期：1998-04-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...

journal_title：Pancreas

authors： Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa T

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...

journal_title：Pancreas

authors： Hane Y,Tsuchikawa T,Nakamura T,Hatanaka KC,Saito T,Tanaka K,Nakanishi Y,Asano T,Noji T,Okamura K,Shichinohe T,Yokota I,Hatanaka Y,Hirano S

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Recent studies have suggested that CCK is not essential for normal pancreatic growth in mice. We examined whether the treatment of hyperglycemia participates in a non-CCK-1-receptor-mediated mechanism of pancreatic regeneration after partial (30%) pancreatectomy (Px) with use of Otsuka Long-Evans T...

journal_title：Pancreas

authors： Yamamoto M,Jia DM,Fukumitsu K,Otsuki M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...

journal_title：Pancreas

authors： Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

更新日期：2019-05-01 00:00:00