Implementation of a simplified method of islet isolation for allogeneic islet transplantation in cynomolgus monkeys.

abstract：:Nicotine is a possible risk factor for chronic pancreatitis and pancreatic cancer. To study the loci where nicotine might exert its effect, we examined interactions between nicotine and rat pancreatic acini. When pancreatic acini were incubated with [3H]nicotine, [3H]nicotine levels in pancreatic acini were increased ...

journal_title：Pancreas

authors： Doi R,Chowdhury P,Nishikawa M,Takaori K,Inoue K,Imamura M,Rayford PL

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...

journal_title：Pancreas

authors： Sugimoto M,Sonntag DP,Flint GS,Boyce CJ,Kirkham JC,Harris TJ,Carr SM,Nelson BD,Bell DA,Barton JG,Traverso LW

更新日期：2018-07-01 00:00:00

abstract：:The influence of the neuropeptide galanin, present in intrapancreatic nerve endings, on the endocrine pancreas is well known. The most potent effect of galanin is inhibition of insulin release. Little is known of its effect on the exocrine pancreas. Whether galanin plays a role in the regulation of exocrine pancreatic...

journal_title：Pancreas

authors： Rünzi M,Müller MK,Schmid P,von Schönfeld J,Goebell H

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS:Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study....

journal_title：Pancreas

authors： Joo KR,Shin HP,Cha JM,Nam S,Huh Y

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...

journal_title：Pancreas

authors： Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...

journal_title：Pancreas

authors： Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

更新日期：2008-08-01 00:00:00

abstract：:We simultaneously measured hepatic insulin removal invasively and estimated hepatic clearance and extraction of insulin pharmacokinetically from cardiac output and peripheral plasma concentrations (relatively) noninvasively. The invasive methods involved continuous electromagnetic measurements of portal venous and hep...

journal_title：Pancreas

authors： Berzins R,Tam YK,Molnar GD,Rajotte RV,Wieczorek KR,McGregor JR,Fawcett DM

更新日期：1986-01-01 00:00:00

abstract：:Metastatic pancreatic cancer (PC) is an aggressive malignancy, with most patients deriving benefit only from first-line chemotherapy. Increasingly, the recommended treatment for those with a germline mutation in a gene involved in homologous recombination repair is with a platinum drug followed by a poly (ADP-ribose) ...

journal_title：Pancreas

authors： Martino C,Pandya D,Lee R,Levy G,Lo T,Lobo S,Frank RC

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...

journal_title：Pancreas

authors： Schneider L,Hackert T,Longerich T,Hartwig W,Fritz S,Krych R,Fortunato F,Gebhard MM,Werner J

更新日期：2010-05-01 00:00:00

abstract：:We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Tsai WY,Lai CS,Tai TY,Lin BJ

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...

journal_title：Pancreas

authors： Gangi A,Malafa M,Klapman J

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...

journal_title：Pancreas

authors： Mouratidis PX,Dalgleish AG,Colston KW

更新日期：2006-01-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...

journal_title：Pancreas

authors： Schlosser W,Gansauge F,Schlosser S,Gansauge S,Beger HG

更新日期：2001-11-01 00:00:00

abstract：:To study the influence of extracellular matrix (ECM) on isolated fetal porcine islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel (MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix for 20 days. The insulin accumulation in the culture medium was determined every fifth...

journal_title：Pancreas

authors： Oberg-Welsh C

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...

journal_title：Pancreas

authors： Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa T

更新日期：2008-08-01 00:00:00

abstract：:Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...

journal_title：Pancreas

authors： De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...

journal_title：Pancreas

authors： Bertilsson S,Kalaitzakis E

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...

journal_title：Pancreas

authors： Maehira H,Iida H,Mori H,Kitamura N,Miyake T,Shimizu T,Tani M

更新日期：2019-02-01 00:00:00

abstract：:Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...

journal_title：Pancreas

authors： Bhat ST,Talkad VD,Pollo DA,Gardner JD

更新日期：1994-01-01 00:00:00

abstract：:Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...

journal_title：Pancreas

authors： Friess H,Büchler M,Krüger M,Beger HG

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...

journal_title：Pancreas

authors： Hane Y,Tsuchikawa T,Nakamura T,Hatanaka KC,Saito T,Tanaka K,Nakanishi Y,Asano T,Noji T,Okamura K,Shichinohe T,Yokota I,Hatanaka Y,Hirano S

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS:MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measure...

journal_title：Pancreas

authors： Baker AF,Koh MY,Williams RR,James B,Wang H,Tate WR,Gallegos A,Von Hoff DD,Han H,Powis G

更新日期：2008-03-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：:We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...

journal_title：Pancreas

authors： Yamaguchi Y,Matsumura F,Liang J,Okabe K,Matsuda T,Ohshiro H,Ishihara K,Akizuki E,Yamada S,Ogawa M

更新日期：1999-05-01 00:00:00

abstract：:Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...

journal_title：Pancreas

authors： Mundlos S,Adler G,Schaar M,Koop I,Arnold R

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...

journal_title：Pancreas

authors： Jutric Z,Grendar J,Hoen HM,Cho SW,Cassera MA,Newell PH,Hammill CW,Hansen PD,Wolf RF

更新日期：2017-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...

journal_title：Pancreas

authors： Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

journal_title：Pancreas

authors： Shah P,Singh MH,Yang YX,Metz DC

更新日期：2013-08-01 00:00:00