Regional Metastatic Behavior of Nonfunctional Pancreatic Neuroendocrine Tumors: Impact of Lymph Node Positivity on Survival.

abstract：OBJECTIVES:Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of t...

journal_title：Pancreas

authors： Tanaka T,Kuroki T,Adachi T,Ono S,Hirabaru M,Soyama A,Kitasato A,Takatsuki M,Hayashi T,Eguchi S

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS:We inhibited I...

journal_title：Pancreas

authors： Li JH,McMillan RH,Begum A,Gocke CB,Matsui W

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides. METHODS:The effects of antisense to miR-21 and miR-221 on cell proliferation, cell cycle arrest, induction of apoptosis, combinat...

journal_title：Pancreas

authors： Park JK,Lee EJ,Esau C,Schmittgen TD

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...

journal_title：Pancreas

authors： Mayumi T,Inui K,Maetani I,Yokoe M,Sakamoto T,Yoshida M,Ko S,Hirata K,Takada T,Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group).

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of A...

journal_title：Pancreas

authors： Neale RE,Youlden DR,Krnjacki L,Kimlin MG,van der Pols JC

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraducta...

journal_title：Pancreas

authors： Nakazato T,Suzuki Y,Tanaka R,Abe N,Masaki T,Mori T,Ohkura Y,Sugiyama M

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...

journal_title：Pancreas

authors： Wang H,Xiu D,Jiang B,Ma C,Yuan C

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...

journal_title：Pancreas

authors： Ntellas P,Dadouli K,Perivoliotis K,Sogka E,Pentheroudakis G,Ioannou M,Hadjichristodoulou C,Tepetes K,Mauri D

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....

journal_title：Pancreas

authors： Xu S,Wei S,Guo Y,Cui D,Yao J

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...

journal_title：Pancreas

authors： Philips T,Kusmartseva I,Gerling IC,Campbell-Thompson M,Wasserfall C,Pugliese A,Longmate JA,Schatz DA,Atkinson MA,Kaddis JS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...

journal_title：Pancreas

authors： Ortega AR,Gómez-Rodríguez R,Romero M,Fernández-Zapardiel S,Céspedes Mdel M,Carrobles JM

更新日期：2011-03-01 00:00:00

abstract：:Wheat amylase inhibitor (WAI) was given to growing rats to determine whether chronic inhibition of intraluminal amylase activity alters pancreatic growth, pancreatic enzyme composition, and secretory responsiveness to cholecystokinin octapeptide (CCK-OP) and carbachol. For 21 days 13 rats were fed amylase inhibitor (A...

journal_title：Pancreas

authors： Kataoka K,DiMagno EP

更新日期：1998-07-01 00:00:00

abstract：:Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...

journal_title：Pancreas

authors： Suda K,Hosokawa Y,Kuroda J,Yuminamochi T,Ishii Y,Nakazawa K

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha) has been implicated as one of the numerous likely mediators of the systemic complications of acute pancreatitis. Recent suggestions that calcium (Ca2+) acts as a signal not only for TNF alpha release but also for TNF alpha action at distant sites led us to hypothesize that the c...

journal_title：Pancreas

authors： Hughes CB,el-Din AB,Kotb M,Gaber LW,Gaber AO

更新日期：1996-07-01 00:00:00

abstract：:To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...

journal_title：Pancreas

authors： Sahel J,Cros RC,Durbec JP,Sarles H,Bank S,Marks IN,Bettarello A,Duarte I,Guarita D,Machado M

更新日期：1986-01-01 00:00:00

abstract：:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...

journal_title：Pancreas

authors： Morioka CY,Saito S,Ohzawa K,Watanabe A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Image-guided radiation therapy allows precise tumor targeting using real-time tracking of radiopaque fiducial markers. To enable appropriate tracking, it is recommended to place fiducials with "ideal fiducial geometry" (IFG). Our objectives were to determine the proportion of patients in whom IFG can be achie...

journal_title：Pancreas

authors： Majumder S,Berzin TM,Mahadevan A,Pawa R,Ellsmere J,Sepe PS,Larosa SA,Pleskow DK,Chuttani R,Sawhney MS

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...

journal_title：Pancreas

authors： Maehira H,Iida H,Mori H,Kitamura N,Miyake T,Shimizu T,Tani M

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...

journal_title：Pancreas

authors： Singh P,Srinivasan R,Wig JD

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...

journal_title：Pancreas

authors： Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) are at a higher risk of developing post-ERCP pancreatitis than patients undergoing diagnostic ERCP. The aim of this study was to evaluate the effectiveness of somatostatin in preventing post-therapeutic ERCP pancreatitis. ...

journal_title：Pancreas

authors： Lee KT,Lee DH,Yoo BM

更新日期：2008-11-01 00:00:00

abstract：:The transport specificity of L-glutamine influx in the perfused rat exocrine pancreas has been investigated using a dual isotope tracer dilution technique. During a single circulation through the isolated pancreas, an epithelial uptake of 71 +/- 1% (n = 10) was measured for L-(3H)glutamine relative to the extracellula...

journal_title：Pancreas

authors： Mann GE,Habara Y,Peran S

更新日期：1986-01-01 00:00:00

abstract：:Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...

journal_title：Pancreas

authors： Lévy P,Lettéron P,Paye F,Molas G,Guimont MC,Pessayre D,Bernades P,Rozé C

更新日期：1997-05-01 00:00:00

abstract：:The nuclear DNA content was assessed by image cytometry on cytologic specimens obtained with fine-needle aspiration biopsy in 96 patients with pancreatic duct carcinoma. Twenty-two of these patients had pancreaticoduodenal resection. According to DNA analysis there were 27 (28%) diploid, 17 (18%) tetraploid, and 52 (5...

journal_title：Pancreas

authors： Linder S,Falkmer U,Hagmar T,Blåsjö M,Sundelin P,von Rosen A

更新日期：1994-11-01 00:00:00

abstract：:The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...

journal_title：Pancreas

authors： Duan RD,Erlanson-Albertsson C

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...

journal_title：Pancreas

authors： Xia QS,Ishigaki Y,Zhao X,Shimasaki T,Nakajima H,Nakagawa H,Takegami T,Chen ZH,Motoo Y

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The aim was to determine whether serum levels of carbohydrate antigen (CA) 19-9, interleukin 6 (IL-6), and YKL-40 could identify advanced disease and poor prognosis in pancreatic cancer (PC) patients intraoperatively diagnosed with locally advanced or metastatic disease. METHODS:Two hundred ninety patients ...

journal_title：Pancreas

authors： Palmquist C,Dehlendorff C,Calatayud D,Hansen CP,Hasselby JP,Johansen JS

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...

journal_title：Pancreas

authors： Kvinlaug K,Kriegler S,Moser M

更新日期：2009-08-01 00:00:00