Abstract:
:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the OCI group survived 71 +/- 2.17 days (range, 69-75 days), and in the OTI group, 73.8 +/- 4.03 days (range, 58-80 days). After necropsy, spontaneous metastases were noted in 100% of the animals. Direct invasion to adjacent organs was observed in four animals, and liver metastases, in three in the OTI group, which were significantly higher compared with the OCI group. On the other hand, peritoneal dissemination was observed only in the OCI group. Other metastatic sites showed no significant difference between the groups. All the histologically noted metastases had K-ras point mutation confirmed by polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP) analysis. We conclude that the homologous OTI model may be more useful than the OCI model. The OTI model may contribute to the development of therapeutic strategies in the field of pancreatic cancer research because of the capacity for invasion to adjacent organs, higher liver metastatic rate, and similarity to the clinical picture of the disease.
journal_name
Pancreasjournal_title
Pancreasauthors
Morioka CY,Saito S,Ohzawa K,Watanabe Adoi
10.1097/00006676-200003000-00007subject
Has Abstractpub_date
2000-03-01 00:00:00pages
152-7issue
2eissn
0885-3177issn
1536-4828journal_volume
20pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd6470
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000911
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000861
更新日期:2017-08-01 00:00:00
abstract::This review article has 4 major objectives to follow pancreatic physiology development more than close to 70 years of intensive and productive basic research. At first, the review will focus on secretion of the pancreatic enzymes with (1) the controls involved, (2) the interrelations existing between secretion and syn...
journal_title:Pancreas
pub_type: 历史文章,杂志文章
doi:10.1097/MPA.0000000000000226
更新日期:2014-11-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract::: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200404000-00021
更新日期:2004-04-01 00:00:00
abstract::In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198910000-00013
更新日期:1989-01-01 00:00:00
abstract::Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leu...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200101000-00001
更新日期:2001-01-01 00:00:00
abstract::Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199701000-00011
更新日期:1997-01-01 00:00:00
abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00004
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of A...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31819975f4
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318247d6af
更新日期:2012-05-01 00:00:00
abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001482
更新日期:2020-02-01 00:00:00
abstract::Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199209000-00002
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181da0f3e
更新日期:2010-10-01 00:00:00
abstract::Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199005000-00004
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153336.50482.59
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200304000-00007
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3180a6f366
更新日期:2007-11-01 00:00:00
abstract::To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199511000-00005
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000175892.97036.a7
更新日期:2005-10-01 00:00:00
abstract::Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199109000-00006
更新日期:1991-09-01 00:00:00
abstract::Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00004
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:Prior studies have indicated that endogenous or exogenous cholecystokinin (CCK) induces transient acinar cell proliferation at about 24 hours after its stimulation. The aims of the present study were to determine the time point when the administration of the CCK-A-receptor antagonist loxiglumide had its maxi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000202960.63977.d1
更新日期:2006-03-01 00:00:00
abstract::Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198808000-00019
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes. METHODS:One hundred twenty-three patients who underwent pancreatectomy for IPMN were analyzed clinicopathologically and radiologically. Invasive IPM carcinomas (IPMCs) were su...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318181b90d
更新日期:2009-01-01 00:00:00
abstract::Nicotine is a possible risk factor for chronic pancreatitis and pancreatic cancer. To study the loci where nicotine might exert its effect, we examined interactions between nicotine and rat pancreatic acini. When pancreatic acini were incubated with [3H]nicotine, [3H]nicotine levels in pancreatic acini were increased ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199503000-00008
更新日期:1995-03-01 00:00:00
abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200308000-00004
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000087
更新日期:2014-03-01 00:00:00