Is Multifocality an Indicator of Aggressive Behavior in Small Bowel Neuroendocrine Tumors?


OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to determine the frequency of multifocal and unifocal SBNETs and compare clinicopathologic factors, somatostatin receptor 2 expression, and survival. METHODS:Clinicopathologic variables from 179 patients with surgically managed SBNETs were collected. Statistical comparisons were made using Welch t-test, Wilcoxon test, and Fisher's exact test. Survival was assessed using the Kaplan-Meier method. Somatostatin receptor 2 expression was analyzed by quantitative polymerase chain reaction, and Ki-67 expression by immunohistochemistry. RESULTS:Multifocal tumors were found in 45% of patients with SBNETs. Clinicopathologic factors such as grade, TNM stage, presence of distant metastases, mean somatostatin receptor 2 expression, success of imaging modalities, and preoperative and postoperative hormone levels were not significantly different between multifocal and unifocal groups. Progression-free survival and overall survival were also not significantly affected by multifocality. CONCLUSIONS:Clinicopathologic features and survival of patients with MFTs and unifocal tumors are remarkably similar. Although the etiology of MFTs is unclear, patients with MFTs do not have a more aggressive clinical course than patients with unifocal SBNETs.






Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR




Has Abstract


2017-10-01 00:00:00
















  • Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy.

    abstract:OBJECTIVES:Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunoh...


    pub_type: 杂志文章


    authors: Nakashima A,Murakami Y,Uemura K,Hayashidani Y,Sudo T,Hashimoto Y,Ohge H,Oda M,Sueda T,Hiyama E

    更新日期:2009-07-01 00:00:00

  • Whipple's procedure plus intraoperative pancreatic duct occlusion for severe chronic pancreatitis: clinical, exocrine, and endocrine consequences during a 3-year follow-up.

    abstract::The present investigation provides follow-up data (up to 36 months) of exocrine and endocrine pancreatic function, inflammatory activity, pain, and body weight in 23 chronic pancreatitis patients submitted to Whipple's procedure plus intraoperative Ethibloc occlusion of the remaining pancreatic duct system between Jan...


    pub_type: 杂志文章


    authors: Schneider MU,Meister R,Domschke S,Zirngibl H,Strebl H,Heptner G,Gebhardt C,Gall FP,Domschke W

    更新日期:1987-01-01 00:00:00

  • Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity?

    abstract:OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...


    pub_type: 杂志文章


    authors: Aoufi Rabih S,García Agudo R,Legaz Huidobro ML,Ynfante Ferrús M,González Carro P,Pérez Roldán F,Ruiz Carrillo F,Tenías Burillo JM

    更新日期:2014-07-01 00:00:00

  • Conversion of human pancreatic acinar cells toward a ductal-mesenchymal phenotype and the role of transforming growth factor β and activin signaling.

    abstract:OBJECTIVE:Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal tr...


    pub_type: 杂志文章


    authors: De Waele E,Wauters E,Ling Z,Bouwens L

    更新日期:2014-10-01 00:00:00

  • Decreased insulin secretion and insulin sensitivity are associated with liver function in subjects with fasting glucose between 100 and 109 mg/dL in Taiwanese population.

    abstract:OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...


    pub_type: 杂志文章


    authors: Hsiao JY,Wang CL,Hsia PJ,Hsieh MC,Hsin SC,Lin KD,Shin SJ

    更新日期:2007-11-01 00:00:00

  • Staplers in palliative bypass surgery for unresectable pancreatic cancer.

    abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...


    pub_type: 杂志文章


    authors: Kairaluoma MI,Kiviniemi H,Laitinen S,Ståhlberg M

    更新日期:1987-01-01 00:00:00

  • Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways.

    abstract:OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...


    pub_type: 杂志文章


    authors: Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

    更新日期:2010-01-01 00:00:00

  • Pancreatic abscess caused by Corynebacterium coyleae mimicking malignant neoplasm.

    abstract::A 50-year-old female was referred to our hospital because of postprandial epigastric pain and pancreatic head mass. On admission, an elastic hard mass with tenderness was palpable in the epigastric region. Laboratory findings showed no abnormalities, except for a slightly elevated C-reactive protein value and iron def...


    pub_type: 杂志文章


    authors: Taguchi M,Nishikawa S,Matsuoka H,Narita R,Abe S,Fukuda K,Miyamoto H,Taniguchi H,Otsuki M

    更新日期:2006-11-01 00:00:00

  • Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.

    abstract:OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...


    pub_type: 杂志文章


    authors: Sarac B,Durmus N,Bagcivan I,Altun A,Turan M,Sencan M

    更新日期:2010-08-01 00:00:00

  • Duct epithelial cells cultured from human pancreas processed for transplantation retain differentiated ductal characteristics.

    abstract::A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...


    pub_type: 杂志文章


    authors: Kolar C,Caffrey T,Hollingsworth M,Scheetz M,Sutherlin M,Weide L,Lawson T

    更新日期:1997-10-01 00:00:00

  • Coagulation, platelets, and acute pancreatitis.

    abstract::Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemos...


    pub_type: 杂志文章,评审


    authors: Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DP

    更新日期:2007-01-01 00:00:00

  • Prediction and Management for Relapse of Type 1 Autoimmune Pancreatitis After Initial Steroid Treatment: A Long-Term Follow-up From China.

    abstract:OBJECTIVES:This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS:One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis usi...


    pub_type: 杂志文章


    authors: Xin L,Meng QQ,Hu LH,Lin H,Pan J,Hao L,Liu PP,Qian W,Wang LW,Li ZS

    更新日期:2018-10-01 00:00:00

  • Acute pancreatitis: which patient is most at risk?

    abstract::This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...


    pub_type: 杂志文章


    authors: Lankisch PG,Pflichthofer D,Lehnick D

    更新日期:1999-11-01 00:00:00

  • Factors predicting recurrence after resection of pancreatic ductal carcinoma.

    abstract:OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...


    pub_type: 杂志文章


    authors: Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

    更新日期:2005-07-01 00:00:00

  • Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...


    pub_type: 杂志文章


    authors: Matsushita Y,Smith B,Delannoy M,Trujillo MA,Chianchiano P,McMillan R,Kamiyama H,Liang H,Thompson ED,Hruban RH,Matsui W,Wood LD,Roberts NJ,Eshleman JR

    更新日期:2019-10-01 00:00:00

  • Long-term correction of hyperglycemia in diabetic mice after implantation of cultured human cells derived from fetal pancreas.

    abstract::Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...


    pub_type: 杂志文章


    authors: Wu F,Jagir M,Powell JS

    更新日期:2004-07-01 00:00:00

  • Clinical study of chronic pancreatitis with focal irregular narrowing of the main pancreatic duct and mass formation: comparison with chronic pancreatitis showing diffuse irregular narrowing of the main pancreatic duct.

    abstract:INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...


    pub_type: 杂志文章


    authors: Wakabayashi T,Kawaura Y,Satomura Y,Fujii T,Motoo Y,Okai T,Sawabu N

    更新日期:2002-10-01 00:00:00

  • Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets.

    abstract:OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...


    pub_type: 杂志文章


    authors: Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

    更新日期:2004-08-01 00:00:00

  • Pancreatic function tests in the rat model of chronic pancreatic insufficiency.

    abstract::It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to deter...


    pub_type: 杂志文章


    authors: Henry JP,Steinberg WM

    更新日期:1993-09-01 00:00:00

  • Pancreatic antioxidant enzyme activity in normoglycemic diabetic prone BB rats.

    abstract::Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...


    pub_type: 杂志文章


    authors: Roza AM,Pieper GM,Johnson CP,Adams MB

    更新日期:1995-01-01 00:00:00

  • Human leukocyte antigens as genetic markers in Greek patients with sporadic pancreatic cancer.

    abstract:PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirme...


    pub_type: 杂志文章


    authors: Kouerinis IA,Zografos G,Tarassi KE,Athanasiades TH,Liontos M,Gorgoulis VG,Korkolis D,Konstandoulakis MM,Fotiadis CI,Androulakis G,Papasteriades CA

    更新日期:2004-07-01 00:00:00

  • PANC-1 pancreatic cancer cell growth inhibited by cucurmosin alone and in combination with an epidermal growth factor receptor-targeted drug.

    abstract:OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...


    pub_type: 杂志文章


    authors: Wang C,Yang A,Zhang B,Yin Q,Huang H,Chen M,Xie J

    更新日期:2014-03-01 00:00:00

  • Interleukin-36α Induces Inflammatory Mediators From Human Pancreatic Myofibroblasts Via a MyD88 Dependent Pathway.

    abstract:OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...


    pub_type: 杂志文章


    authors: Nishida A,Inatomi O,Fujimoto T,Imaeda H,Tani M,Andoh A

    更新日期:2017-04-01 00:00:00

  • Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma.

    abstract:OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...


    pub_type: 杂志文章


    authors: Coppola D,Helm J,Ghayouri M,Malafa MP,Wang HG

    更新日期:2011-04-01 00:00:00

  • Aggressive surgery for borderline resectable pancreatic cancer: evaluation of National Comprehensive Cancer Network guidelines.

    abstract:OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...


    pub_type: 杂志文章


    authors: Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

    更新日期:2013-08-01 00:00:00

  • Racial Differences in Gastroenteropancreatic Neuroendocrine Tumor Treatment and Survival in the United States.

    abstract:OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...


    pub_type: 杂志文章


    authors: Kessel E,Naparst M,Alpert N,Diaz K,Ahn E,Wolin E,Taioli E,Kim MK

    更新日期:2021-01-01 00:00:00

  • High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome.

    abstract:OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...


    pub_type: 杂志文章


    authors: Einama T,Kagata Y,Tsuda H,Morita D,Ogata S,Ueda S,Takigawa T,Kawarabayashi N,Fukatsu K,Sugiura Y,Matsubara O,Hatsuse K

    更新日期:2006-05-01 00:00:00

  • Reported findings on endoscopic ultrasound examinations for chronic pancreatitis: toward establishing an endoscopic ultrasound quality benchmark.

    abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...


    pub_type: 杂志文章


    authors: Gardner TB,Taylor DJ,Gordon SR

    更新日期:2014-01-01 00:00:00

  • Acute Pancreatitis and Use of Pancreatitis-Associated Drugs: A 10-Year Population-Based Cohort Study.

    abstract:OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...


    pub_type: 杂志文章


    authors: Bertilsson S,Kalaitzakis E

    更新日期:2015-10-01 00:00:00

  • The natural history of hereditary chronic pancreatitis: a study of 12 cases compared to chronic alcoholic pancreatitis.

    abstract::The aim of this study was to document the natural history of chronic hereditary pancreatitis and to compare its evolution to that of chronic alcoholic pancreatitis. Twelve subjects with chronic hereditary pancreatitis were followed up for a mean duration of 15.8 years (range, 1-23) and compared to subjects with chroni...


    pub_type: 杂志文章


    authors: Paolini O,Hastier P,Buckley M,Maes B,Demarquay JF,Staccini P,Bellon S,Caroli-Bosc FX,Dumas R,Delmont J

    更新日期:1998-10-01 00:00:00