Contribution of thymidylate synthase to gemcitabine therapy for advanced pancreatic cancer.

abstract：UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...

journal_title：Pancreas

authors： Grochola LF,Taubert H,Greither T,Bhanot U,Udelnow A,Würl P

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...

journal_title：Pancreas

authors： Sarac B,Durmus N,Bagcivan I,Altun A,Turan M,Sencan M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...

journal_title：Pancreas

authors： Yeh TS,Ho YP,Chiu CT,Chen TC,Jan YY,Chen MF

更新日期：2005-04-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) binding sites in adult rat exocrine pancreas were studied by autoradiography using slide-mounted frozen tissue sections with mono-iodinated ANF (101-126) as the tracer. Radiolabel was displaced by unlabeled atrial peptide (IC50 = 2 X 10(-11) M). High specific labeling was found in pancr...

journal_title：Pancreas

authors： Chabot JG,Morel G,Kopelman H,Belles-Isles M,Heisler S

更新日期：1987-01-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to evaluate the severity of patients with acute pancreatitis (AP) on chronic pancreatitis (CP) and compare this to patients with AP without CP. METHODS:The Maryland Health Services database was queried for all adult inpatient discharges with a primary diagnosis of AP from 1...

journal_title：Pancreas

authors： Akshintala VS,Hutfless SM,Yadav D,Khashab MA,Lennon AM,Makary MA,Hirose K,Andersen DK,Kalloo AN,Singh VK

更新日期：2013-11-01 00:00:00

abstract：:This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...

journal_title：Pancreas

authors： Nichols MT,Russ PD,Chen YK

更新日期：2006-10-01 00:00:00

abstract：:Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...

journal_title：Pancreas

authors： Göke B,Keim V,Dagorn JC,Arnold R,Adler G

更新日期：1990-05-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：:We examined whether pancreas grafts preserved by the two-layer method maintained adenine nucleotides pool as substrates for ATP synthesis before reperfusion and had the ability to recover pancreatic tissue perfusion and synthesize ATP promptly after reperfusion. After preservation by the two-layer cold storage method ...

journal_title：Pancreas

authors： Kim Y,Kuroda Y,Tanioka Y,Matsumoto S,Fujita H,Sakai T,Hamano M,Suzuki Y,Ku Y,Saitoh Y

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies. METHODS:Data were assessed in 2 dimensions, based on RNA-seq si...

journal_title：Pancreas

authors： Blobner BM,Bellin MD,Beilman GJ,Shelton CA,Park HJ,Whitcomb DC

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...

journal_title：Pancreas

authors： Olesen SS,Graversen C,Bouwense SA,Wilder-Smith OH,van Goor H,Drewes AM

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance. METHODS:Rats underwent pancreatic duct ligation (PDL) and were followed through 12 months. Aging rats were studied at 12 and...

journal_title：Pancreas

authors： Bluth M,Mueller CM,Pierre J,Callender G,Kandil E,Viterbo D,Fu SL,Sugawara A,Okamoto H,Zenilman ME

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of t...

journal_title：Pancreas

authors： Tanaka T,Kuroki T,Adachi T,Ono S,Hirabaru M,Soyama A,Kitasato A,Takatsuki M,Hayashi T,Eguchi S

更新日期：2013-04-01 00:00:00

abstract：:Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...

journal_title：Pancreas

authors： Joly I,David A,Payan MJ,Sahel J,Sarles H

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...

journal_title：Pancreas

authors： Ostenson CG,Chen J,Sheu L,Gaisano HY

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:The consumption of green tea is associated with a lower risk of several types of human carcinomas. A number of studies have focused on the possible mechanisms of cancer prevention by tea extracts, especially polyphenols such as epigallocatechin-3-gallate (EGCG). AIMS AND METHODOLOGY:Green tea-derived EGCG...

journal_title：Pancreas

authors： Takada M,Nakamura Y,Koizumi T,Toyama H,Kamigaki T,Suzuki Y,Takeyama Y,Kuroda Y

更新日期：2002-07-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...

journal_title：Pancreas

authors： Azria D,Ychou M,Jacot W,Thezenas S,Lemanski C,Senesse P,Prost P,Delard R,Masson B,Dubois JB

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Image-guided radiation therapy allows precise tumor targeting using real-time tracking of radiopaque fiducial markers. To enable appropriate tracking, it is recommended to place fiducials with "ideal fiducial geometry" (IFG). Our objectives were to determine the proportion of patients in whom IFG can be achie...

journal_title：Pancreas

authors： Majumder S,Berzin TM,Mahadevan A,Pawa R,Ellsmere J,Sepe PS,Larosa SA,Pleskow DK,Chuttani R,Sawhney MS

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...

journal_title：Pancreas

authors： Mayumi T,Inui K,Maetani I,Yokoe M,Sakamoto T,Yoshida M,Ko S,Hirata K,Takada T,Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group).

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：:The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to disc...

journal_title：Pancreas

authors： Brunicardi FC,Mullen Y

更新日期：1994-05-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...

journal_title：Pancreas

authors： Jo JH,Chung MJ,Park JY,Bang S,Park SW,Chung JB,Song SY

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...

journal_title：Pancreas

authors： Celli R,Tang LH,Cai G,Freedman-Weiss M,Colunga M,Salem RR,Majumdar S,Jain D

更新日期：2019-01-01 00:00:00