Abstract:
:The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to discuss their clinical results and ways to achieve higher success rates. The Islet Transplantation Registry revealed there have been 178 islet transplants in human subjects worldwide: 11% of the patients have achieved insulin-independence; however, 20% of the patients have achieved insulin-independence during 1990-1992; 20% of the patients have functioning islet grafts as determined by circulating C-peptide levels; however 65% have functioning grafts during 1990-1992. These patients still require exogenous insulin; however, many demonstrate improved glucose control and decreased insulin requirements, and are considered to have a partially successful transplant. The major issues for clinical success are islet preparation, donor islet number, and prevention of rejection. We are hopeful that islet transplantation will realize its full potential this decade and await the advance in technology that will result in clinical success rates approaching that of solid organ transplantation.
journal_name
Pancreasjournal_title
Pancreasauthors
Brunicardi FC,Mullen Ydoi
10.1097/00006676-199405000-00001subject
Has Abstractpub_date
1994-05-01 00:00:00pages
281-90issue
3eissn
0885-3177issn
1536-4828journal_volume
9pub_type
杂志文章,评审相关文献
PANCREAS文献大全abstract::It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199803000-00010
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001505
更新日期:2020-03-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199805000-00006
更新日期:1998-05-01 00:00:00
abstract::A 50-year-old female was referred to our hospital because of postprandial epigastric pain and pancreatic head mass. On admission, an elastic hard mass with tenderness was palpable in the epigastric region. Laboratory findings showed no abnormalities, except for a slightly elevated C-reactive protein value and iron def...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236730.08747.69
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200303000-00008
更新日期:2003-03-01 00:00:00
abstract::Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00003
更新日期:1999-04-01 00:00:00
abstract::Protein phosphatases have recently been recognized to represent an important, independently regulated portion of cellular signaling cascades. Although reversible phosphorylation of multiple pancreatic proteins has been described, suggesting a role for these enzymes, little is known about the characteristics of protein...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199407000-00002
更新日期:1994-07-01 00:00:00
abstract:INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001707
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182258a15
更新日期:2011-08-01 00:00:00
abstract::Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199001000-00007
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Pancreatic stellate cells (PSCs) play a crucial role during pancreatic fibrosis development. Hydrogen sulfide (H2S) is a recently discovered gaseous transmitter, whose role in PSCs has not been explored yet. In the present study, we examined the effects of sodium hydrosulfide (NaHS), an H2S donor, on rat PSC...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318223645b
更新日期:2012-01-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00019
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000000475
更新日期:2016-03-01 00:00:00
abstract::Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199510000-00008
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract::Solid pseudopapillary tumor of the pancreas is a rare neoplasm with low malignant potential, which affects predominantly young females. Only approximately 10% to 15% cases of solid pseudopapillary tumors (SPTs) are malignant. We present the case of a 57-year-old woman who developed malignant SPT of the pancreas. Meanw...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e31824d52c7
更新日期:2012-11-01 00:00:00
abstract::The diagnostic value of bile salt-dependent lipase for pancreatic diseases was tested in sera of 187 patients. Of these patients, 76 suffered from pancreatic carcinoma, 43 from nonmalignant liver diseases (cirrhosis and chronic hepatitis), 18 from acute pancreatitis, and 20 from chronic pancreatitis. The remaining sub...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00009
更新日期:1993-09-01 00:00:00
abstract::Diabetes mellitus secondary to chronic pancreatitis is characterized by a progressive destruction of the pancreas, including loss of the islet cells, leading to a form of diabetes that can mimic both type 1 and type 2 diabetes. Glucagon-like peptide 1(7-36)amide (GLP-1), an intestinally derived insulinotropic hormone,...
journal_title:Pancreas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006676-200001000-00004
更新日期:2000-01-01 00:00:00
abstract::The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001634
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS:One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis usi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001147
更新日期:2018-10-01 00:00:00
abstract::A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198812000-00013
更新日期:1988-01-01 00:00:00
abstract:UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180547709
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318247d6af
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:This study aimed to compare severity of acute pancreatitis (AP) and mortality rates between transferred and nontransferred patients and to determine the factors that influence the decision to transfer. METHODS:A retrospective analysis coding a statewide administrative database in Maryland was conducted. Sev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000179
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000633
更新日期:2016-10-01 00:00:00
abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001382
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000204
更新日期:2015-01-01 00:00:00
abstract::Cutaneous metastasis of an occult malignancy to the umbilicus has come to be known as a Sister Mary Joseph's nodule (SMJN). More than 400 cases of this well-described clinical presentation of advanced gastrointestinal and gynecologic cancers have been reported. Pancreatic cancer presenting as a SMJN is a rare phenomen...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000240602.18688.43
更新日期:2007-01-01 00:00:00