Effects of hydrogen sulfide on rat pancreatic stellate cells.

abstract：OBJECTIVES:Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine,...

journal_title：Pancreas

authors： Steele CW,Oien KA,McKay CJ,Jamieson NB

更新日期：2011-11-01 00:00:00

abstract：:Our objective was to analyze conservative management in a large series of acute necrotizing pancreatitis (ANP) patients in a specialized center for pancreatic disease in the Internal Medicine and Emergency Department of a 1,500-bed hospital. One hundred ninety-nine patients with ANP were considered (mean age, 55.4 +/-...

journal_title：Pancreas

authors： Uomo G,Visconti M,Manes G,Calise F,Laccetti M,Rabitti PG

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...

journal_title：Pancreas

authors： Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

更新日期：2010-08-01 00:00:00

abstract：:Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...

journal_title：Pancreas

authors： von Rosen A,Linder S,Harmenberg U,Pegert S

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance. METHODS:Rats underwent pancreatic duct ligation (PDL) and were followed through 12 months. Aging rats were studied at 12 and...

journal_title：Pancreas

authors： Bluth M,Mueller CM,Pierre J,Callender G,Kandil E,Viterbo D,Fu SL,Sugawara A,Okamoto H,Zenilman ME

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...

journal_title：Pancreas

authors： Crucitti F,Doglietto GB,Frontera D,Viola G,Morganti AG,Valentini V,Alfonsi G,Trodella L,Cellini N

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：:Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...

journal_title：Pancreas

authors： Yokomatsu H,Satake K,Hiura A,Tsutsumi M,Suganuma M

更新日期：1994-07-01 00:00:00

abstract：:Human pure pancreatic juice (PPJ) and serum were analyzed for free fatty acids (FFAs) to study whether the damage to pancreatic cell membranes in pancreatitis is reflected as abnormal FFAs concentration and composition. Patients consisted of 13 normal controls, 7 patients with acute pancreatitis (AP) in remission, and...

journal_title：Pancreas

authors： Miyake H,Harada H,Ochi K,Oka H,Ishibashi T,Kimura I

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the tumor necrosis factor alpha (TNF-alpha) releasing capacity in whole blood stimulated by lipopolysaccharide (LPS) in patients with pancreatic cancer during the perioperative period, and before and after chemotherapy. METHODS:The current study involved a total of 39 pa...

journal_title：Pancreas

authors： Terakawa N,Satoi S,Takai S,Yanagimoto H,Takahashi K,Komiyama Y,A-Hon K,Kamiyama Y,Takahashi H

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...

journal_title：Pancreas

authors： Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa T

更新日期：2008-08-01 00:00:00

abstract：:Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...

journal_title：Pancreas

authors： Andersson R,Wang X,Sun Z,Deng X,Soltesz V,Ihse I

更新日期：1998-08-01 00:00:00

abstract：:Stimulation of intact rat pancreatic acini with cholecystokinin (CCK) enhances the phosphorylation of the ribosomal protein S6 in a dose-dependent manner with half maximal stimulation at 40 pM and maximal stimulation at 1 nM CCK octapeptide. Soluble cellular extracts contained S6 kinase activity assayed using purified...

journal_title：Pancreas

authors： Sung CK,Williams JA

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...

journal_title：Pancreas

authors： Jutric Z,Grendar J,Hoen HM,Cho SW,Cassera MA,Newell PH,Hammill CW,Hansen PD,Wolf RF

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:Pancreatic trauma is rare and often missed during initial assessment of patients with abdominal trauma. This study reviews our experience of managing pancreatic trauma at a tertiary referral center and discusses the diagnostic and therapeutic challenges. METHODS:A retrospective study of our prospectively ma...

journal_title：Pancreas

authors： Thomas H,Madanur M,Bartlett A,Marangoni G,Heaton N,Rela M

更新日期：2009-03-01 00:00:00

abstract：:In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...

journal_title：Pancreas

authors： Howard JM,Woldenberg LS,Conover SV

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:We evaluated how well phase II trials in locally advanced and metastatic pancreatic cancer (LAMPC) meet current recommendations for trial design. METHODS:We conducted a systematic review of phase II first-line treatment trial for LAMPC. We assessed baseline characteristics, type of comparison, and primary e...

journal_title：Pancreas

authors： Tang M,Chen J,Goldstein D,Links M,Lord S,Marschner I,Simes RJ,Lee CK

更新日期：2019-11-01 00:00:00

abstract：:Protein phosphatases have recently been recognized to represent an important, independently regulated portion of cellular signaling cascades. Although reversible phosphorylation of multiple pancreatic proteins has been described, suggesting a role for these enzymes, little is known about the characteristics of protein...

journal_title：Pancreas

authors： Lutz MP,Pinon DI,Miller LJ

更新日期：1994-07-01 00:00:00

abstract：:This review critically analyzes how machine learning is being used to support clinical decision-making in the management of potentially resectable pancreatic cancer. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines, electronic searches of MEDLINE, Embase, PubMed, and Coc...

journal_title：Pancreas

authors： Bradley A,van der Meer R,McKay C

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Ethnic disparities in pancreatic cancer (PanCan) incidence exist, but little is known about incidence trends in heterogeneous Asian Americans. We examined PanCan incidence and temporal patterns among detailed ethnic populations, including Asian American subgroups. METHODS:A total of 71,099 invasive exocrine ...

journal_title：Pancreas

authors： Liu L,Zhang J,Deapen D,Stern MC,Sipin A,Pandol SJ,Setiawan VW

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...

journal_title：Pancreas

authors： Benson AB 3rd,Strosberg J,Joish VN,Dharba S,Sapre D,Lapuerta P

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...

journal_title：Pancreas

authors： Celli R,Tang LH,Cai G,Freedman-Weiss M,Colunga M,Salem RR,Majumdar S,Jain D

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...

journal_title：Pancreas

authors： Rogers MB,Aveson V,Firek B,Yeh A,Brooks B,Brower-Sinning R,Steve J,Banfield JF,Zureikat A,Hogg M,Boone BA,Zeh HJ,Morowitz MJ

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer. METHODS:We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 pati...

journal_title：Pancreas

authors： Niu L,Chen J,He L,Liao M,Yuan Y,Zeng J,Li J,Zuo J,Xu K

更新日期：2013-10-01 00:00:00

abstract：:Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...

journal_title：Pancreas

authors： Song M,Zaninovic V,Kim D,Gukovsky I,Gukovskaya A,Kang K,Pandol S

更新日期：1999-04-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...

journal_title：Pancreas

authors： Lin Y,Kikuchi S,Tamakoshi A,Yagyu K,Obata Y,Kurosawa M,Inaba Y,Kawamura T,Motohashi Y,Ishibashi T,JACC Study Group.

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is the main diagnostic modality for pancreatic mass lesions. However, cytology is often indeterminate, leading to repeat FNAs and delay in care. Here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (FISH) ...

journal_title：Pancreas

authors： Reicher S,Boyar FZ,Albitar M,Sulcova V,Agersborg S,Nga V,Zhou Y,Li G,Venegas R,French SW,Chung DS,Stabile BE,Eysselein VE,Anguiano A

更新日期：2011-10-01 00:00:00

abstract：AIM:To assess the feasibility and usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) for evaluation of pancreatic exocrine function. METHODOLOGY:S-MRCP was performed in 20 patients with mild (n = 8) or severe (n = 12) chronic pancreatitis (according to the grade of exocrine pancreatic...

journal_title：Pancreas

authors： Czakó L,Endes J,Takács T,Boda K,Lonovics J

更新日期：2001-10-01 00:00:00