Abstract:
OBJECTIVES:Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine, have modest clinical benefit and marginal survival advantage. MicroRNAs have been shown to have a role in oncogenesis, invasion, and metastases via epigenetic posttranscriptional gene regulation. Our objective was to discuss the clinical impact of microRNAs within PDAC. METHODS:This review details the understanding of microRNAs to date and explores the clinical utility of microRNAs in PDAC. RESULTS:Recent studies have focused on the impact of microRNA expression in PDAC, many of which have shown the diagnostic, predictive, and prognostic utility of microRNA profiling in PDAC identifying numerous potential targets including miR-21, miR-196a, and miR-217. CONCLUSIONS:MicroRNA stability in body fluid and tissue samples makes this area one of the most promising for earlier detection of PDAC. Indeed, microRNAs may in the future serve as a long-awaited screening tool for PDAC. Furthermore, microRNA expression profiling in PDAC may be incorporated into modern treatment algorithms to enhance therapeutic management. Equally as exciting is the potential for novel therapeutics directed against these important disease mediators.
journal_name
Pancreasjournal_title
Pancreasauthors
Steele CW,Oien KA,McKay CJ,Jamieson NBdoi
10.1097/MPA.0b013e3182218ffbsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
1165-71issue
8eissn
0885-3177issn
1536-4828pii
00006676-201111000-00002journal_volume
40pub_type
杂志文章,评审相关文献
PANCREAS文献大全abstract:OBJECTIVE:Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma oc...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e31816907ab
更新日期:2008-07-01 00:00:00
abstract::Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181f66cdf
更新日期:2010-11-01 00:00:00
abstract::The nuclear DNA content was assessed by image cytometry on cytologic specimens obtained with fine-needle aspiration biopsy in 96 patients with pancreatic duct carcinoma. Twenty-two of these patients had pancreaticoduodenal resection. According to DNA analysis there were 27 (28%) diploid, 17 (18%) tetraploid, and 52 (5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199411000-00016
更新日期:1994-11-01 00:00:00
abstract::Changes in pancreatic growth and in mRNA concentrations in rat pancreas were monitored by dot-blot hybridization with cloned cDNAs of rat amylase, chymotrypsinogen B, proinsulin I, and actin during the pre- and postnatal period in the rat. Wistar rats were killed at the 18th day of gestation and at the 1st, 10th, 20th...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199007000-00008
更新日期:1990-07-01 00:00:00
abstract::It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to deter...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00015
更新日期:1993-09-01 00:00:00
abstract::Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...
journal_title:Pancreas
pub_type:
doi:10.1097/00006676-200311000-00014
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001390
更新日期:2019-10-01 00:00:00
abstract::Chronic pancreatitis (CP) is one condition in which epidemiologic studies have demonstrated a definite association with pancreatic adenocarcinoma (PAC). The pathophysiologic and molecular events that either predispose to the development of, or potentiate the growth of, PAC are unknown. Mutation of the codon 12 K-ras g...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200004000-00005
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d705d4
更新日期:2010-10-01 00:00:00
abstract::Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00016
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00001
更新日期:2004-05-01 00:00:00
abstract::Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199605000-00004
更新日期:1996-05-01 00:00:00
abstract::It has been suggested that the severity of an attack of acute pancreatitis is related to the presence of intraglandular trypsinogen activation and that disease severity is also reflected by the degree of the acute-phase protein response. In this study we examine the relationships among amylase release, the degree of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199505000-00005
更新日期:1995-05-01 00:00:00
abstract::Adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. In the present work the effects of ADP beta S on insulin somatostatin, and glucagon secretions were investigated in dogs. In vivo, in anesthetized fasted dogs, i.v...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Benign pancreatic hyperenzymemia is characterized by a long-term increase of serum pancreatic enzymes in otherwise healthy subjects. This study was designed to determine (a) whether all pancreatic enzymes are elevated, (b) the extent of each enzyme increase, (c) the relative frequency of the familial form, an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000138
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:In a continuation of previous work, Reg3γ protein was further evaluated as a biomarker of pancreatic injury using immunohistochemistry in an additional species. METHODS:Mice and rats were treated with intraperitoneal cerulein injections, creating acute pancreatic injury. Mice received 2, 4, or 6 doses, and r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001382
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000637
更新日期:2016-08-01 00:00:00
abstract::This review article has 4 major objectives to follow pancreatic physiology development more than close to 70 years of intensive and productive basic research. At first, the review will focus on secretion of the pancreatic enzymes with (1) the controls involved, (2) the interrelations existing between secretion and syn...
journal_title:Pancreas
pub_type: 历史文章,杂志文章
doi:10.1097/MPA.0000000000000226
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Although cell kinetics of the gastrointestinal mucosa has been extensively examined, that of the pancreas has not been fully analyzed. AIM:To determine the renewal rate of pancreatic cells directly. METHODOLOGY:Postnatal proliferative activity and cellular renewal of the parenchymal cells in ICR mouse pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200203000-00006
更新日期:2002-03-01 00:00:00
abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract::The effects of manganese (Mn2+) on phosphorylation activity in the rat pancreas were examined in an in vitro phosphorylation assay and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of endogenous proteins. Several histones were phosphorylated in the presence of pancreatic supernatant obtained ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199009000-00015
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVES:Neoadjuvant chemotherapy (NAC) has improved overall survival in patients with pancreatic ductal adenocarcinoma (PDAC), but its effects on immune gene signatures are unknown. Here, we examined the immune transcriptome after NAC for PDAC. METHODS:Resected tumor specimens were obtained from 140 patients with P...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001665
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001188
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d7ace1
更新日期:2010-10-01 00:00:00
abstract::A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199710000-00008
更新日期:1997-10-01 00:00:00
abstract::Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199201000-00017
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:The role of melatonin in human insulin regulation is poorly understood. AIM:To investigate the influence of melatonin supplementation on glucose and insulin levels and on lipid metabolism in blood serum and the liver. METHODOLOGY:The acute melatonin effects on insulin secretion in male Wistar rats were i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200208000-00009
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS:The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirme...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00054
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Survivin, an antiapoptotic gene inhibited by p53, is overexpressed in human cancers and correlates with chemotherapy resistance. Here, we investigated the mutual regulatory mechanism between MGMT (O-methylguanine DNA methyltransferase) and survivin. METHODS:This study used standard techniques for protein an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000299
更新日期:2015-05-01 00:00:00
abstract::A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00023
更新日期:1993-01-01 00:00:00