Manganese modulates protein phosphorylation in the rat pancreas: in vitro evidence for cation selective regulation.

abstract：:Conscious rats were infused with optimal doses of secretin (16 clinical units [CU]/kg/h), cerulein (0.25 microgram/kg/h), and both for varying periods of time over 24 h. The presence of zymogen granules in acinar cells and the tissue content of enzymes showed progressive decreases over 3 and 12 h for cerulein and secr...

journal_title：Pancreas

authors： Rausch U,Rüdiger K,Vasiloudes P,Kern H,Scheele G

更新日期：1986-01-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...

journal_title：Pancreas

authors： Dong X,Gao SL,Xie QP,Xu L,Xu YL,Wu YL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...

journal_title：Pancreas

authors： Bertilsson S,Kalaitzakis E

更新日期：2015-10-01 00:00:00

abstract：:Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...

journal_title：Pancreas

authors： Nakano S,Tachibana I,Otsuki M

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...

journal_title：Pancreas

authors： Wang H,Xiu D,Jiang B,Ma C,Yuan C

更新日期：2014-05-01 00:00:00

abstract：:Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...

journal_title：Pancreas

authors： Song M,Zaninovic V,Kim D,Gukovsky I,Gukovskaya A,Kang K,Pandol S

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:Serum pancreastatin is a sensitive and specific diagnostic biomarker in neuroendocrine tumors (NETs). Elevated pancreastatin levels are associated with worse progression-free survival and overall survival in small bowel and pancreatic NETs. In this study, we investigated the clinical significance of elevated...

journal_title：Pancreas

authors： Khan TM,Garg M,Warner RR,Uhr JH,Divino CM

更新日期：2016-08-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：:The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...

journal_title：Pancreas

authors： Terashima H,Debas HT,Bunnett NW

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...

journal_title：Pancreas

authors： Schneider L,Hackert T,Longerich T,Hartwig W,Fritz S,Krych R,Fortunato F,Gebhard MM,Werner J

更新日期：2010-05-01 00:00:00

abstract：:It has been suggested that the severity of an attack of acute pancreatitis is related to the presence of intraglandular trypsinogen activation and that disease severity is also reflected by the degree of the acute-phase protein response. In this study we examine the relationships among amylase release, the degree of t...

journal_title：Pancreas

authors： Heath DI,Cruickshank A,Gudgeon AM,Jehanli A,Shenkin A,Imrie CW

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...

journal_title：Pancreas

authors： Law JK,Ahmed A,Singh VK,Akshintala VS,Olson MT,Raman SP,Ali SZ,Fishman EK,Kamel I,Canto MI,Dal Molin M,Moran RA,Khashab MA,Ahuja N,Goggins M,Hruban RH,Wolfgang CL,Lennon AM

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION AND AIM:Recent studies have suggested that CCK is not essential for normal pancreatic growth in mice. We examined whether the treatment of hyperglycemia participates in a non-CCK-1-receptor-mediated mechanism of pancreatic regeneration after partial (30%) pancreatectomy (Px) with use of Otsuka Long-Evans T...

journal_title：Pancreas

authors： Yamamoto M,Jia DM,Fukumitsu K,Otsuki M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...

journal_title：Pancreas

authors： Ikemoto T,Noguchi H,Fujita Y,Takita M,Shimoda M,Sugimoto K,Jackson A,Naziruddin B,Shimada M,Levy MF,Matsumoto S

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...

journal_title：Pancreas

authors： Matsushita Y,Smith B,Delannoy M,Trujillo MA,Chianchiano P,McMillan R,Kamiyama H,Liang H,Thompson ED,Hruban RH,Matsui W,Wood LD,Roberts NJ,Eshleman JR

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...

journal_title：Pancreas

authors： Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...

journal_title：Pancreas

authors： Sell NM,Lee GC,Fernández-Del Castillo C,Ferrone CR,Warshaw AL,Hong TS,Blaszkowsky LS,Lillemoe KD,Qadan M

更新日期：2020-08-01 00:00:00

abstract：:The secretin stimulation test is the most sensitive and specific test for pancreatic function. It is usually performed using biologically derived porcine secretin. Several shortages of biologic porcine secretin have occurred in the past few years. The aim of this study was to compare synthetic porcine secretin to biol...

journal_title：Pancreas

authors： Somogyi L,Cintron M,Toskes PP

更新日期：2000-10-01 00:00:00

abstract：INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...

journal_title：Pancreas

authors： Wakabayashi T,Kawaura Y,Satomura Y,Fujii T,Motoo Y,Okai T,Sawabu N

更新日期：2002-10-01 00:00:00

abstract：:In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...

journal_title：Pancreas

authors： Howard JM,Woldenberg LS,Conover SV

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...

journal_title：Pancreas

authors： LaBarre NT,Morgan KA,Adams DB,Waljee AK,Coté GA,Elmunzer BJ

更新日期：2019-01-01 00:00:00

abstract：:Although surgical procedures that improve pancreatic drainage alleviate abdominal pain in the vast majority of patients with chronic pancreatitis, postoperative absorption and nutritional status are less predictable. The present study was designed to determine the efficacy of pancreatic enzyme supplementation in maint...

journal_title：Pancreas

authors： Van Hoozen CM,Peeke PG,Taubeneck M,Frey CF,Halsted CH

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas include neoplasms with varying likelihood of progression to malignancy. The aim of this study was to investigate a natural course of main duct IPMNs with a lower likelihood of malignancy. METHODS:Twenty main duct IPMNs with a lower l...

journal_title：Pancreas

authors： Uehara H,Ishikawa O,Ikezawa K,Kawada N,Inoue T,Takakura R,Takano Y,Tanaka S,Takenaka A

更新日期：2010-07-01 00:00:00

abstract：:Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...

journal_title：Pancreas

authors： Conget I,Sarri Y,Somoza N,Vives M,Novials A,Ariza A,Fernández-Alvarez J,Pujol-Borrell R,Gomis R

更新日期：1997-01-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...

journal_title：Pancreas

authors： Majumder S,Gierisch JM,Bastian LA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma oc...

journal_title：Pancreas

authors： Woltering EA,Salvo VA,O'Dorisio TM,Lyons J 3rd,Li G,Zhou Y,Seward JR,Go VL,Vinik AI,Mamikunian P,Mamikunian G

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...

journal_title：Pancreas

authors： Tian Y,Xue Y,Ruan G,Cheng K,Tian J,Qiu Q,Xiao M,Li H,Yang H,Wang L

更新日期：2015-01-01 00:00:00