A 5-year experience of benign pancreatic hyperenzymemia.

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00

abstract：:We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Tsai WY,Lai CS,Tai TY,Lin BJ

更新日期：1996-04-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...

journal_title：Pancreas

authors： Morioka CY,Saito S,Ohzawa K,Watanabe A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...

journal_title：Pancreas

authors： Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

更新日期：2014-04-01 00:00:00

abstract：:To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...

journal_title：Pancreas

authors： Lee YL,Kwon HY,Park HS,Lee TH,Park HJ

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:Recent observations demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in sensory ganglion neurons. Because sensory nerves are implicated in pancreatic inflammatory processes, we studied the colocal...

journal_title：Pancreas

authors： Lázár BA,Jancsó G,Oszlács O,Nagy I,Sántha P

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...

journal_title：Pancreas

authors： Schlosser W,Gansauge F,Schlosser S,Gansauge S,Beger HG

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as ...

journal_title：Pancreas

authors： Miyasaka K,Kawanami T,Shimokata H,Ohta S,Funakoshi A

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...

journal_title：Pancreas

authors： Marabita F,Islam MS

更新日期：2017-01-01 00:00:00

abstract：:The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular f...

journal_title：Pancreas

authors： Satake K,Hiura A,Ha SS,Nishiwaki H,Umeyama K

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...

journal_title：Pancreas

authors： Wang X,Li YG,Du Y,Zhu JY,Li Z

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...

journal_title：Pancreas

authors： Eibl G,Forgacs B,Hotz HG,Buhr HJ,Foitzik T

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...

journal_title：Pancreas

authors： Apodaca-Torrez FR,Goldenberg A,Lobo EJ,Farah JF,Triviño T,Montero EF,Schraibman V,Benvenuto RB,Artigiani Neto R

更新日期：2007-11-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is synthesized in islet B cells and stored in the secretory granules. We examined whether IAPP and insulin are released in parallel in humans. Arginine hydrochloride (5 g) was injected intravenously at three glucose levels in 11 healthy 58-year-old female subjects. In the fasting state...

journal_title：Pancreas

authors： Larsson H,Ahrén B

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00

abstract：:This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...

journal_title：Pancreas

authors： Nichols MT,Russ PD,Chen YK

更新日期：2006-10-01 00:00:00

abstract：:A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...

journal_title：Pancreas

authors： Lee WY,Tzeng CC,Jin YT,Chow NH,Yip CM,Lee JC

更新日期：1993-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...

journal_title：Pancreas

authors： Jamal H,Suda K,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1993-03-01 00:00:00

abstract：:Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...

journal_title：Pancreas

authors： Yao CZ,Poston GJ,Ishizuka J,Townsend CM Jr,Thompson JC

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:Protein kinase C (PKC) is involved in cell growth, differentiation, and apoptosis. We investigated the effects of the PKC activator, the tetradecanylphorbol acetate (TPA), in human pancreatic cancer cells. METHODS:Cell proliferation was measured by thymidine incorporation. Expression of cell cycle proteins ...

journal_title：Pancreas

authors： Salabat MR,Ding XZ,Flesche JB,Ujiki MB,Robin TP,Talamonti MS,Bell RH Jr,Adrian TE

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP). METHODS:Fifty patients with AP were prospectively enrolled. Erythrocyte sedimentation rate and CRP were measured at admission and every 12 hours for 48 hours aft...

journal_title：Pancreas

authors： Pongprasobchai S,Jianjaroonwong V,Charatcharoenwitthaya P,Komoltri C,Tanwandee T,Leelakusolvong S,Pausawasdi N,Srikureja W,Chainuvati S,Prachayakul V,Manatsathit S,Kachintorn U

更新日期：2010-11-01 00:00:00

abstract：:We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...

journal_title：Pancreas

authors： Imai Y,Morishita S,Ikeda Y,Toyoda M,Ashizawa T,Yamamoto K,Inoue T,Ishikawa T

更新日期：1999-04-01 00:00:00

abstract：:Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...

journal_title：Pancreas

authors： Hosch SB,Knoefel WT,Metz S,Stoecklein N,Niendorf A,Broelsch CE,Izbicki JR

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:This study aimed to compare severity of acute pancreatitis (AP) and mortality rates between transferred and nontransferred patients and to determine the factors that influence the decision to transfer. METHODS:A retrospective analysis coding a statewide administrative database in Maryland was conducted. Sev...

journal_title：Pancreas

authors： Anand G,Hutfless SM,Akshintala VS,Khashab MA,Lennon AM,Makary MA,Hirose K,Andersen DK,Kalloo AN,Singh VK

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...

journal_title：Pancreas

authors： Ikemoto T,Noguchi H,Fujita Y,Takita M,Shimoda M,Sugimoto K,Jackson A,Naziruddin B,Shimada M,Levy MF,Matsumoto S

更新日期：2010-10-01 00:00:00

abstract：:Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...

journal_title：Pancreas

authors： Hine RJ,Srivastava S,Milner JA,Ross SA

更新日期：2003-11-01 00:00:00

abstract：:Neuroendocrine tumors (NETs) arise in most organs of the body and share many common pathologic features. However, a variety of different organ-specific systems have been developed for nomenclature, grading, and staging of NETs, causing much confusion. This review examines issues in the pathologic assessment of NETs th...

journal_title：Pancreas

authors： Klimstra DS,Modlin IR,Coppola D,Lloyd RV,Suster S

更新日期：2010-08-01 00:00:00

abstract：:We examined whether pancreas grafts preserved by the two-layer method maintained adenine nucleotides pool as substrates for ATP synthesis before reperfusion and had the ability to recover pancreatic tissue perfusion and synthesize ATP promptly after reperfusion. After preservation by the two-layer cold storage method ...

journal_title：Pancreas

authors： Kim Y,Kuroda Y,Tanioka Y,Matsumoto S,Fujita H,Sakai T,Hamano M,Suzuki Y,Ku Y,Saitoh Y

更新日期：1997-04-01 00:00:00