Abstract:
:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to 140 mM NaHCO3, which is essential for normal digestion. This article provides an overview of the basics of pancreatic ductal physiology and pathophysiology. In the first part of the article, we discuss the ductal electrolyte and fluid transporters and their regulation. The central role of cystic fibrosis transmembrane conductance regulator (CFTR) is highlighted, which is much more than just a Cl channel. We also review the role of pancreatic ducts in severe debilitating diseases such as cystic fibrosis (caused by various genetic defects of cftr), pancreatitis, and diabetes mellitus. Stimulation of ductal secretion in cystic fibrosis and pancreatitis may have beneficial effects in their treatment.
journal_name
Pancreasjournal_title
Pancreasauthors
Pallagi P,Hegyi P,Rakonczay Z Jrdoi
10.1097/MPA.0000000000000421subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1211-33issue
8eissn
0885-3177issn
1536-4828pii
00006676-201511000-00009journal_volume
44pub_type
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