Abstract:
OBJECTIVES:Treatment of the pain caused by chronic pancreatitis (CP) is not standardized. Knowledge of the response to placebo in this setting may aid the design of future trials. We aimed at investigating the placebo effect on abdominal pain remission rates in patients with CP. METHODS:MEDLINE, EMBASE, and Scopus were searched, and randomized placebo-controlled trials in CP providing data on abdominal pain remission rates in placebo arms were included. Pooled estimates of the placebo rate were calculated using random-effects logistic regression analysis. Stratum-specific rates for different patients and study-level covariates were calculated to account for heterogeneity. RESULTS:Seven randomized controlled trials (202 placebo-treated patients) met the predefined criteria. The pooled estimate of the placebo rate for pain remission was 19.9% (95% confidence interval, 9%-36%). There was a statistically significant heterogeneity among the studies (I(2) = 76%; P < 0.001). A multicenter design, a run-in period of less than 2 weeks, and absence of a washout in crossover trials were all significant sources of heterogeneity associated with higher placebo responses. CONCLUSIONS:This meta-analysis identifies for the first time the efficacy of placebo for pain in CP and variables determining it. These data provide a sound basis for designing future placebo-controlled randomized clinical trials for the treatment of pain in CP.
journal_name
Pancreasjournal_title
Pancreasauthors
Capurso G,Cocomello L,Benedetto U,Cammà C,Delle Fave Gdoi
10.1097/MPA.0b013e318249ce93subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1125-31issue
7eissn
0885-3177issn
1536-4828journal_volume
41pub_type
杂志文章,meta分析相关文献
PANCREAS文献大全abstract::In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199608000-00003
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000161888.02244.7a
更新日期:2005-05-01 00:00:00
abstract::Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199508000-00005
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. METHODS:This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182480ab7
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180547709
更新日期:2007-07-01 00:00:00
abstract::The present investigation provides follow-up data (up to 36 months) of exocrine and endocrine pancreatic function, inflammatory activity, pain, and body weight in 23 chronic pancreatitis patients submitted to Whipple's procedure plus intraoperative Ethibloc occlusion of the remaining pancreatic duct system between Jan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198711000-00016
更新日期:1987-01-01 00:00:00
abstract::The involvement of endogenous prostaglandins (PGs) in pancreatic endocrine and exocrine secretion was investigated, using the isolated and perfused dog pancreas. Spontaneous production of both PGE2 and 6-keto-PGF1 alpha was recorded in venous effluent. Prostaglandin production increased following stimulation with both...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198912000-00008
更新日期:1989-01-01 00:00:00
abstract::Phospholipase C (PLC) isozymes are believed to play a role in regulating pancreatic exocrine and endocrine secretion. In an attempt to investigate the role of PLC, we examined the distribution patterns of PLC isozymes in the normal rat pancreas by Western blot analysis and immunohistochemistry. Western blot analysis w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200101000-00008
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31823ba75a
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB). This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP). METHODS:Male CD mice (median weight,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181b28d11
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180304825
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001188
更新日期:2019-01-01 00:00:00
abstract::The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199107000-00011
更新日期:1991-07-01 00:00:00
abstract::To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198611000-00001
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:The role of melatonin in human insulin regulation is poorly understood. AIM:To investigate the influence of melatonin supplementation on glucose and insulin levels and on lipid metabolism in blood serum and the liver. METHODOLOGY:The acute melatonin effects on insulin secretion in male Wistar rats were i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200208000-00009
更新日期:2002-08-01 00:00:00
abstract::Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199605000-00004
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000072
更新日期:2014-05-01 00:00:00
abstract::The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00006
更新日期:1994-01-01 00:00:00
abstract::Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199705000-00004
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181a9f12a
更新日期:2009-08-01 00:00:00
abstract::Acute pancreatic duct obstruction causes hyperamylasemia and mild pancreatic inflammation. We hypothesized that bile exclusion from the gut, which stimulates pancreatic secretion, exacerbates acute pancreatitis caused by pancreatic duct obstruction. Rats were surgically prepared with gastric, duodenal, bile, and pancr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199103000-00008
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVES:Intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasia (PanIN) are both precancerous lesions. Papillary mucinous neoplasms have been described in patients with IPMN, but their relationship is still poorly understood. The aims of this study were to look for PanIN lesions in ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000437639.38383.41
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200208000-00019
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000685
更新日期:2017-01-01 00:00:00
abstract::The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervation was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholinesterase (AChE) activity and the induced fluor...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00013
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunoh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181a16d28
更新日期:2009-07-01 00:00:00
abstract::In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198910000-00013
更新日期:1989-01-01 00:00:00
abstract::A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-198802000-00020
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182258a15
更新日期:2011-08-01 00:00:00
abstract::Chronic pancreatitis (CP) is one condition in which epidemiologic studies have demonstrated a definite association with pancreatic adenocarcinoma (PAC). The pathophysiologic and molecular events that either predispose to the development of, or potentiate the growth of, PAC are unknown. Mutation of the codon 12 K-ras g...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200004000-00005
更新日期:2000-04-01 00:00:00