Abstract:
OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients. RESULTS:Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP. CONCLUSIONS:Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
journal_name
Pancreasjournal_title
Pancreasauthors
Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VLdoi
10.1097/MPA.0b013e3182258a15subject
Has Abstractpub_date
2011-08-01 00:00:00pages
809-14issue
6eissn
0885-3177issn
1536-4828journal_volume
40pub_type
杂志文章,多中心研究相关文献
PANCREAS文献大全abstract:OBJECTIVES:Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is a promising diagnostic marker for pancreatic cancer. In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunoh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181a16d28
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The present study aimed to assess the clinical significance of PXR in pancreatic adenocarcinoma. METHODS:Pregnane X receptor and its...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000405
更新日期:2015-10-01 00:00:00
abstract::The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00006
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides. METHODS:The effects of antisense to miR-21 and miR-221 on cell proliferation, cell cycle arrest, induction of apoptosis, combinat...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181ba82e1
更新日期:2009-10-01 00:00:00
abstract::Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199005000-00004
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318201654a
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000175892.97036.a7
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0b013e3182557c24
更新日期:2013-01-01 00:00:00
abstract::Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199201000-00017
更新日期:1992-01-01 00:00:00
abstract::We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant (CINC) expression by bronchoalveolar macrophages in acute pancreatitis. Pancreatitis was induced by four intramuscular injections of cerulein (50 micrograms/kg at 1-h intervals) in Wistar ra...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199905000-00005
更新日期:1999-05-01 00:00:00
abstract:INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200304000-00007
更新日期:2003-04-01 00:00:00
abstract::This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000227912.71202.2c
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000588
更新日期:2016-07-01 00:00:00
abstract::Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199701000-00011
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Nuclear factor κB (NF-κB) plays an intrinsic role in promoting growth, angiogenesis, and metastasis in pancreatic cancer (PC) and serves as a mechanism underlying therapeutic resistance. Accordingly, we investigated the efficacy of bioactive phytochemicals in inhibiting radiotherapy (RT)-induced NF-κB activi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821f677d
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000147084.70125.41
更新日期:2005-03-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199207000-00009
更新日期:1992-01-01 00:00:00
abstract::Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181f66cdf
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effects of exogenously administered lactate and pyruvate on blood perfusion in endogenous and transplanted islets. METHODS:Anesthetized Wistar-Furth rats were given lactate or pyruvate intravenously, and regional blood perfusion was studied 3 or 30 minutes late...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31824bd97c
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:Scutellaria baicalensis has been a subject of research interest due to its potential multiple therapeutic benefits. This study was to examine the distribution of baicalein, wogonin, oroxylin A and their glucuronide/sulfate-conjugated metabolites in plasma, colon, small intestine, lung, liver, pancreas, kidne...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318232e130
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d6bc69
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...
journal_title:Pancreas
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MPA.0000000000000301
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000199
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d7ace1
更新日期:2010-10-01 00:00:00
abstract:UNLABELLED:Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. METHODS:: In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31816fd7b6
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000431
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000150110.45017.fc
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3180a6f366
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153615.55761.00
更新日期:2005-04-01 00:00:00
abstract::To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199005000-00013
更新日期:1990-05-01 00:00:00