Abstract:
:Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. We studied the effect of IAPP on proinsulin biosynthesis in rat insulinoma (RINr) cells. Glucose at concentrations of 0, 15, 30, 60, 100, and 300 mg/dl stimulated proinsulin biosynthesis in a dose-responsive and and actino-mycin D-inhibitable manner after 6 h of incubation. At a glucose concentration of 300 mg/dl, IAPP decreased the mean responses of proinsulin biosynthesis to 61.2 and 29% at concentrations of 0.1 and 1 microM, respectively, compared with the IAPP-free control. In conclusion, IAPP inhibits glucose-induced proinsulin biosynthesis in RINr cells. IAPP might play an important role in the pathogenesis of type 2 diabetes mellitus.
journal_name
Pancreasjournal_title
Pancreasauthors
Chuang LM,Wu HP,Jou TS,Tai TY,Lin BJdoi
10.1097/00006676-199207000-00009subject
Has Abstractpub_date
1992-01-01 00:00:00pages
472-6issue
4eissn
0885-3177issn
1536-4828journal_volume
7pub_type
杂志文章相关文献
PANCREAS文献大全abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199311000-00010
更新日期:1993-11-01 00:00:00
abstract::The effect of a potent and long-acting bradykinin B2-receptor antagonist (HOE140) on acute pancreatitis induced by retrograde infusion of trypsin and taurocholate into the pancreatic duct was studied in rats. HOE140 was administered subcutaneously immediately before and 3 h after the induction of pancreatitis and the ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199610000-00011
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:The present study describes a simple and cost-effective islet isolation procedure. Using this method, allogeneic islets reverse diabetes in cynomolgus monkeys. METHODS:Pancreatic tissue from 11 cynomolgus monkeys were digested, collected, and purified using a simplified method. Islet quantification, purity,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000437322.44975.13
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:To investigate embryology of complete and incomplete pancreas divisum (PD). METHODS:We analyzed anatomy of the pancreatic duct system in 44 cases of complete PD and 41 cases of incomplete PD. Under the concept of branch fusion between the ventral and dorsal pancreatic ducts, incomplete PD was divided into 3...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000240607.49183.7e
更新日期:2007-01-01 00:00:00
abstract::Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199007000-00005
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVES:The authors investigated differential expression of cdx2 in intraductal papillary mucinous neoplasm of the pancreas (IPMN) and ductal adenocarcinoma. METHODS:Patients with IPMN (n = 23) and pancreatic ductal adenocarcinoma (n = 30) were studied. Expression of cdx2 mRNA, CDX2 protein, muc2 mRNA, MUC2 apomuci...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153615.55761.00
更新日期:2005-04-01 00:00:00
abstract::Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199801000-00006
更新日期:1998-01-01 00:00:00
abstract::We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both se...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00005
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:The aim was to determine whether serum levels of carbohydrate antigen (CA) 19-9, interleukin 6 (IL-6), and YKL-40 could identify advanced disease and poor prognosis in pancreatic cancer (PC) patients intraoperatively diagnosed with locally advanced or metastatic disease. METHODS:Two hundred ninety patients ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001466
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200210000-00021
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182016a08
更新日期:2011-03-01 00:00:00
abstract::Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Co...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199701000-00001
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200111000-00001
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001123
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dab19a
更新日期:2010-10-01 00:00:00
abstract::Fetal and neonatal pancreatic islets have lower insulin secretory responses compared with adult islets. In culture conditions and after treatment with mammosomatotropic hormones, neonatal islets undergo maturation of the secretory machinery that might involve regulation of cell-cell contacts within the islet. This stu...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200108000-00008
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31827b2d7c
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000786
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000605
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001496
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes. METHODS:One hundred twenty-three patients who underwent pancreatectomy for IPMN were analyzed clinicopathologically and radiologically. Invasive IPM carcinomas (IPMCs) were su...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318181b90d
更新日期:2009-01-01 00:00:00
abstract::In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199608000-00003
更新日期:1996-08-01 00:00:00
abstract::Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00016
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Ethnic disparities in pancreatic cancer (PanCan) incidence exist, but little is known about incidence trends in heterogeneous Asian Americans. We examined PanCan incidence and temporal patterns among detailed ethnic populations, including Asian American subgroups. METHODS:A total of 71,099 invasive exocrine ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001337
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Serum pancreastatin is a sensitive and specific diagnostic biomarker in neuroendocrine tumors (NETs). Elevated pancreastatin levels are associated with worse progression-free survival and overall survival in small bowel and pancreatic NETs. In this study, we investigated the clinical significance of elevated...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000572
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318247d6af
更新日期:2012-05-01 00:00:00
abstract::To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199511000-00005
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001229
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001064
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000334
更新日期:2015-07-01 00:00:00