Effects of a bradykinin receptor antagonist (HOE140) on taurocholate-induced acute pancreatitis in rats.

abstract：OBJECTIVES:Animal models are essential to understand the pathogenesis of acute pancreatitis (AP) and to develop new therapeutic strategies. Although it has been shown that cerulein-induced AP is associated with pain in experimental animals, most experiments are carried out without any pain-relieving treatment because r...

journal_title：Pancreas

authors： Stumpf F,Algül H,Thoeringer CK,Schmid RM,Wolf E,Schneider MR,Dahlhoff M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...

journal_title：Pancreas

authors： Zhang X,Duan W,Lee WN,Zhang Y,Xiang F,Liu Q,Go VL,Xiao GG

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...

journal_title：Pancreas

authors： Mitnala S,Pondugala PK,Guduru VR,Rabella P,Thiyyari J,Chivukula S,Boddupalli S,Hardikar AA,Reddy DN

更新日期：2010-08-01 00:00:00

abstract：:The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...

journal_title：Pancreas

authors： Massoumi RL,Hines OJ,Eibl G,King JC

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of A...

journal_title：Pancreas

authors： Neale RE,Youlden DR,Krnjacki L,Kimlin MG,van der Pols JC

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...

journal_title：Pancreas

authors： Dong X,Gao SL,Xie QP,Xu L,Xu YL,Wu YL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...

journal_title：Pancreas

authors： Choi J,Wang J,Ren G,Thakor AS

更新日期：2018-08-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：:The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four s...

journal_title：Pancreas

authors： Hauer-Jensen M,Christensen K,Wilson HD,Schedl HP

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Administration of multiple low doses of streptozotocin (mld-SZ) to mice results in the development of autoimmune diabetes. Hyperglycemia does not develop until a few days after the last injection. In this study, we explored immune-related alterations found in the very early stages of this diabetic syndrome an...

journal_title：Pancreas

authors： Karabatas LM,Pastorale C,de Bruno LF,Maschi F,Pivetta OH,Lombardo YB,Chemes H,Basabe JC

更新日期：2005-05-01 00:00:00

abstract：:Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...

journal_title：Pancreas

authors： Mundlos S,Adler G,Schaar M,Koop I,Arnold R

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...

journal_title：Pancreas

authors： Bertilsson S,Kalaitzakis E

更新日期：2015-10-01 00:00:00

abstract：:Acute pancreatic duct obstruction causes hyperamylasemia and mild pancreatic inflammation. We hypothesized that bile exclusion from the gut, which stimulates pancreatic secretion, exacerbates acute pancreatitis caused by pancreatic duct obstruction. Rats were surgically prepared with gastric, duodenal, bile, and pancr...

journal_title：Pancreas

authors： Murayama KM,Drew JB,Yokoo H,Joehl RJ

更新日期：1991-03-01 00:00:00

abstract：:To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...

journal_title：Pancreas

authors： Fabris C,Munaretto S,Basso D,Dodi G,Infantino A,Piccoli A,Meggiato T,Fogar P,Panozzo MP,Del Favero G

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...

journal_title：Pancreas

authors： Inui K,Masamune A,Igarashi Y,Ohara H,Tazuma S,Sugiyama M,Suzuki Y,Miyoshi H,Yamamoto S,Takeyama Y,Nakano E,Takuma K,Sakagami J,Hayashi K,Kogure A,Ito T,Mukai T,Maetani I,Nagahama M,Serikawa M,Ueki T,Furuya K,I

更新日期：2018-07-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：:The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...

journal_title：Pancreas

authors： Hackert T,Klaiber U,Pausch T,Mihaljevic AL,Büchler MW

更新日期：2020-09-01 00:00:00

abstract：:The involvement of endogenous prostaglandins (PGs) in pancreatic endocrine and exocrine secretion was investigated, using the isolated and perfused dog pancreas. Spontaneous production of both PGE2 and 6-keto-PGF1 alpha was recorded in venous effluent. Prostaglandin production increased following stimulation with both...

journal_title：Pancreas

authors： Kuroda T,Sodeyama H,Hanazaki K,Horigome N,Kajikawa S,Yamagishi K,Horiuchi A,Iwatsuki K,Chiba S,Homma T

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...

journal_title：Pancreas

authors： Einama T,Kagata Y,Tsuda H,Morita D,Ogata S,Ueda S,Takigawa T,Kawarabayashi N,Fukatsu K,Sugiura Y,Matsubara O,Hatsuse K

更新日期：2006-05-01 00:00:00

abstract：:A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...

journal_title：Pancreas

authors： Bastid C,Sahel J,Choux R,Payan MJ,Sarles H

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...

journal_title：Pancreas

authors： Jo JH,Chung MJ,Park JY,Bang S,Park SW,Chung JB,Song SY

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...

journal_title：Pancreas

authors： Sugimoto M,Sonntag DP,Flint GS,Boyce CJ,Kirkham JC,Harris TJ,Carr SM,Nelson BD,Bell DA,Barton JG,Traverso LW

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...

journal_title：Pancreas

authors： Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：:A 66-year-old patient had been admitted four times for recurrent episodes of acute pancreatitis. At each time, elevated serum calcium levels, between 13.5-14.5 mg/dl, were found. Surgical drainage of necrotic pancreatic tissue had to be done on one occasion. Extensive investigations failed to disclose any conventional...

journal_title：Pancreas

authors： Waele BD,Smitz J,Willems G

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...

journal_title：Pancreas

authors： Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner H

更新日期：2016-07-01 00:00:00

abstract：:This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

journal_title：Pancreas

authors： Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

更新日期：1990-03-01 00:00:00

abstract：:Reports of a so-called "mucin-producing tumor of the pancreas" are increasing worldwide. Although the clinicopathologic features and therapeutic strategies of this tumor have been enthusiastically investigated, there are still many unanswered questions regarding this ailment. In this study, problems in the diagnosis a...

journal_title：Pancreas

authors： Kimura W,Kuroda A,Makuuchi M

更新日期：1998-04-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:It is of utmost importance that autoimmune pancreatitis (AIP) be differentiated from pancreatic cancer (PC) because some AIP cases undergo unnecessary laparotomy or pancreatic resection on suspicion of PC. This study aimed to develop an appropriate strategy for differentiating between AIP and PC. METHODS:Cl...

journal_title：Pancreas

authors： Kamisawa T,Imai M,Yui Chen P,Tu Y,Egawa N,Tsuruta K,Okamoto A,Suzuki M,Kamata N

更新日期：2008-10-01 00:00:00