Abstract:
:The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four segments; the duodenum and three distal segments of equal length. Weight of intestine and mucosa, and mucosal sucrase, isomaltase, lactase, and alkaline phosphatase activity were measured 10-15 days following pancreatic duct occlusion, or sham-operation. The duodenum of pancreatic duct-occluded animals exhibited significant hypertrophy. In general, specific and total disaccharidase activities were greater in duct-occluded animals than in controls throughout the intestine. The increase was more pronounced in distal than in proximal segments. The sucrase/isomaltase ratio was significantly greater in pancreatic duct-occluded animals than in controls in the two distal segments. Alkaline phosphatase activity was not affected by pancreatic duct occlusion. The greater relative increase of disaccharidase activities and sucrase/isomaltase activity ratios in the distal segments of duct-occluded animals, indicates a more important regulatory role of pancreatic enzymes in the distal small intestine. It is concluded that regulation of intestinal brush-border enzyme activity by pancreatic secretion is selective for enzyme and site as follows: disaccharidases, but not alkaline phosphatase, are regulated; the sucrase subunit of the sucrase/isomaltase complex is most sensitive to regulation, while lactase is least sensitive; and the regulatory effect on disaccharidases is greater in distal than in proximal intestine.
journal_name
Pancreasjournal_title
Pancreasauthors
Hauer-Jensen M,Christensen K,Wilson HD,Schedl HPdoi
10.1097/00006676-198705000-00008subject
Has Abstractpub_date
1987-01-01 00:00:00pages
295-302issue
3eissn
0885-3177issn
1536-4828journal_volume
2pub_type
杂志文章相关文献
PANCREAS文献大全abstract::This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000227912.71202.2c
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000431
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001019
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to perform an external validation of 2 Asian prognostic indices for patients with advanced pancreatic cancer. METHODS:A score was calculated in patients treated with frontline therapy derived from the factors Eastern Cooperative Oncology Group Performance Status, localization...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31823bcc7b
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001721
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182649979
更新日期:2013-03-01 00:00:00
abstract::Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000620
更新日期:2016-07-01 00:00:00
abstract::Although previous reports suggest interactions between the endocrine and the exocrine pancreas, insulin's effect on pancreatic exocrine function remains unclear. Chronic pancreatic fistulae were created in five dogs; these animals were studied using the euglycemic, hyperinsulinemic clamp technique. After a 30-min unst...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199605000-00004
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is increased in experimental acute pancreatitis. The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis. METHODS:Acute pancreatitis was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to determine whether the efficacy of pancrelipase/pancreatin (CREON®) may be affected by the concomitant use of proton pump inhibitors (PPIs)/histamine-2 receptor antagonists (H2RAs). METHODS:An analysis of integrated data from all clinical trials of pancrelipase/pancreatin supported by Abb...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31828784ef
更新日期:2013-08-01 00:00:00
abstract::We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199604000-00006
更新日期:1996-04-01 00:00:00
abstract::Leucine is known to enhance insulin secretion from islets of Langerhans, and insulin promotes leucine uptake in peripheral tissues. The present studies were designed to elucidate the effects of leucine on glucose responsiveness and stimulus secretion coupling in mouse islets of Langerhans. The effects of 20 mM leucine...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199103000-00015
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001434
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001142
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION:Although cell kinetics of the gastrointestinal mucosa has been extensively examined, that of the pancreas has not been fully analyzed. AIM:To determine the renewal rate of pancreatic cells directly. METHODOLOGY:Postnatal proliferative activity and cellular renewal of the parenchymal cells in ICR mouse pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200203000-00006
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:Thymidylate synthase (TS) inhibitors activate human equilibrative nucleoside transporter 1. We evaluated the contribution of TS expression to determine a treatment method providing an effect from gemcitabine (GEM). METHODS:The expression of 5-fluorouracil (5-FU) and GEM metabolic factors (5-FU: TS, dihydrop...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181dec17d
更新日期:2010-11-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199805000-00006
更新日期:1998-05-01 00:00:00
abstract::Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181f66cdf
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION AND AIMS:Extracellular matrix (ECM) components participate in the process of tissue repair and development of fibrosis in the pancreas. We studied the production kinetics of ECM components and transforming growth factor (TGF)-beta1 and identified their production sites in the pancreas following pancreatiti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200303000-00018
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180304825
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this s...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MPA.0000000000001370
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:The aim was to determine whether serum levels of carbohydrate antigen (CA) 19-9, interleukin 6 (IL-6), and YKL-40 could identify advanced disease and poor prognosis in pancreatic cancer (PC) patients intraoperatively diagnosed with locally advanced or metastatic disease. METHODS:Two hundred ninety patients ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001466
更新日期:2020-01-01 00:00:00
abstract::Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00016
更新日期:1993-07-01 00:00:00
abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00004
更新日期:1987-01-01 00:00:00
abstract::In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198805000-00004
更新日期:1988-01-01 00:00:00
abstract::The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000179727.15716.82
更新日期:2005-11-01 00:00:00
abstract::A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199710000-00008
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVES:The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001642
更新日期:2020-10-01 00:00:00
abstract::ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00011
更新日期:2004-05-01 00:00:00