Type 1 and Type 2 Autoimmune Pancreatitis: Distinctive Clinical and Pathological Features, But Are There Any Differences at Magnetic Resonance? Experience From a Referral Center.

Abstract:

OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalities, enhancement pattern, extrapancreatic involvement, and main pancreatic duct alterations. RESULTS:Pancreatic parenchyma resulted in hypointensity on T1-weighted images in 65 (98.5%) of 66 cases in type 1 and in 17 (94.5%) of 18 in type 2 (P > 0.05) and in hyperintensity on T2-weighted images in 41 (62%) of 66 and in 15 (83.4%) of 18, respectively (P > 0.05). Lesions were hypovascular in 64 (97%) of 66 cases in type 1 and in 16 (88.9%) of 18 in type 2 with delayed contrast retention in 56 (84.8%) of 66 and in 17 (94.5%) of 18, respectively (P > 0.05). Autoimmune cholangitis was found in 29 (43.9%) of 66 patients with type 1 and in 3 (16.7%) of 18 with type 2 (P = 0.02); renal involvement was observed in 20 (30.3%) of 66 and 1 (5.5%) of 18, respectively (P = 0.02). Both subtypes presented with multiple stenoses (P > 0.05). Dilation of upstream duct was more frequent in type 1 (P = 0.02). CONCLUSIONS:Magnetic resonance imaging is useful in detecting extrapancreatic involvement, typically seen in type 1. Dilation of the upstream duct suggests type 1 AIP.

journal_name

Pancreas

journal_title

Pancreas

authors

Negrelli R,Boninsegna E,Avesani G,Zamboni GA,Brozzi L,Frulloni L,Manfredi R,Pozzi Mucelli R

doi

10.1097/MPA.0000000000001142

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1115-1122

issue

9

eissn

0885-3177

issn

1536-4828

journal_volume

47

pub_type

杂志文章

相关文献

PANCREAS文献大全
  • Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.

    abstract::Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199805000-00006

    authors: Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

    更新日期:1998-05-01 00:00:00

  • Protective effect of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced acute pancreatitis in rats.

    abstract::This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199003000-00008

    authors: Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

    更新日期:1990-03-01 00:00:00

  • Efficacy of stone density on noncontrast computed tomography in predicting the outcome of extracorporeal shock wave lithotripsy for patients with pancreatic stones.

    abstract:OBJECTIVES:Patients with chronic pancreatitis are managed by extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones. Stone density on noncontrast computed tomography (NCCT) is used to predict stone composition and fragility, but no report investigating the pancreatic stone density has been documented. We ai...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000277

    authors: Ohyama H,Mikata R,Ishihara T,Tsuyuguchi T,Sakai Y,Sugiyama H,Yasui S,Ishii K,Itoh S,Nishikawa T,Watanabe Y,Yokosuka O

    更新日期:2015-04-01 00:00:00

  • Clinical study of chronic pancreatitis with focal irregular narrowing of the main pancreatic duct and mass formation: comparison with chronic pancreatitis showing diffuse irregular narrowing of the main pancreatic duct.

    abstract:INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-200210000-00011

    authors: Wakabayashi T,Kawaura Y,Satomura Y,Fujii T,Motoo Y,Okai T,Sawabu N

    更新日期:2002-10-01 00:00:00

  • Conversion of human pancreatic acinar cells toward a ductal-mesenchymal phenotype and the role of transforming growth factor β and activin signaling.

    abstract:OBJECTIVE:Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal tr...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000154

    authors: De Waele E,Wauters E,Ling Z,Bouwens L

    更新日期:2014-10-01 00:00:00

  • "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas.

    abstract:OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000199

    authors: Aso T,Ohtsuka T,Matsunaga T,Kimura H,Watanabe Y,Tamura K,Ideno N,Osoegawa T,Takahata S,Shindo K,Ushijima Y,Aishima S,Oda Y,Ito T,Mizumoto K,Tanaka M

    更新日期:2014-11-01 00:00:00

  • Endocrine pancreas development: effects of metabolic and intergenerational programming caused by a protein-restricted diet.

    abstract::Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...

    journal_title:Pancreas

    pub_type: 杂志文章,评审

    doi:10.1097/MPA.0b013e3182236320

    authors: Frantz ED,Peixoto-Silva N,Pinheiro-Mulder A

    更新日期:2012-01-01 00:00:00

  • Highly selective inhibition of inducible nitric oxide synthase ameliorates experimental acute pancreatitis.

    abstract:OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is increased in experimental acute pancreatitis. The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis. METHODS:Acute pancreatitis was in...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:

    authors: Sandstrom P,Brooke-Smith ME,Thomas AC,Grivell MB,Saccone GT,Toouli J,Svanvik J

    更新日期:2005-01-01 00:00:00

  • Late development of pancreas necrosis during acute pancreatitis: an underestimated phenomenon associated with high morbidity and mortality.

    abstract:OBJECTIVE:The purpose of this study is to assess the prognostic significance of late parenchymal pancreas necrosis as observed on serial contrast-enhanced computed tomographic (CT) scan. METHODS:Eighty-four patients with acute necrotizing pancreatitis were included. All initial CT scans were examined on complete contr...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e31802e01ec

    authors: Wijffels NA,van Walraven LA,Ophof PJ,Hop WC,van der Harst E,Lange JF

    更新日期:2007-03-01 00:00:00

  • Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis.

    abstract:OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3181d6bc69

    authors: Mitnala S,Pondugala PK,Guduru VR,Rabella P,Thiyyari J,Chivukula S,Boddupalli S,Hardikar AA,Reddy DN

    更新日期:2010-08-01 00:00:00

  • Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas.

    abstract:OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/01.mpa.0000172566.70619.58

    authors: Tei E,Mehta S,Tulachan SS,Yew H,Hembree M,Preuett B,Snyder CL,Yamataka A,Miyano T,Gittes GK

    更新日期:2005-08-01 00:00:00

  • Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis.

    abstract:OBJECTIVE:The transcription factor Stat1 is a member of the family of signal transducers and transcription activators and responds to interferon-γ stimulation. p21 is a p53-responsive gene for cell cycle regulation and mediates Stat1 antitumor activity. The aim of this study was to analyze their expression for predicti...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000074

    authors: Sun Y,Yang S,Sun N,Chen J

    更新日期:2014-05-01 00:00:00

  • Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia.

    abstract:OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e318162cb26

    authors: Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa T

    更新日期:2008-08-01 00:00:00

  • Racial Differences in Gastroenteropancreatic Neuroendocrine Tumor Treatment and Survival in the United States.

    abstract:OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000001707

    authors: Kessel E,Naparst M,Alpert N,Diaz K,Ahn E,Wolin E,Taioli E,Kim MK

    更新日期:2021-01-01 00:00:00

  • Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling.

    abstract:OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3181ce719e

    authors: Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

    更新日期:2010-08-01 00:00:00

  • Impact of Antibiotic-Resistant Bacterial and Fungal Infections in Outcome of Acute Pancreatitis.

    abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000001019

    authors: Moka P,Goswami P,Kapil A,Xess I,Sreenivas V,Saraya A

    更新日期:2018-04-01 00:00:00

  • Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy.

    abstract:OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0000000000000203

    authors: Estrella JS,Ma LT,Milton DR,Yao JC,Wang H,Rashid A,Broaddus RR

    更新日期:2014-10-01 00:00:00

  • Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology, Carcinoembryonic Antigen, and Amylase in Intraductal Papillary Mucinous Neoplasm.

    abstract:OBJECTIVES:The aim of this study was to determine the accuracy of cytology, carcinoembryonic antigen (CEA), and amylase levels in the preoperative diagnosis of intraductal papillary mucinous neoplasms (IPMNs). METHODS:An international registry was started in 2005 and included patients with clinically suspected IPMNs. ...

    journal_title:Pancreas

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPA.0000000000000559

    authors: Moris M,Raimondo M,Woodward TA,Skinner V,Arcidiacono PG,Petrone MC,De Angelis C,Manfrè S,Fusaroli P,Asbun H,Stauffer J,Wallace MB

    更新日期:2016-07-01 00:00:00

  • Treatment of duct carcinoma of the pancreas with the LH-RH analogue buserelin.

    abstract::Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199209000-00002

    authors: Friess H,Büchler M,Krüger M,Beger HG

    更新日期:1992-01-01 00:00:00

  • Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.

    abstract:OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:

    authors: Jia D,Taguchi M,Otsuki M

    更新日期:2005-01-01 00:00:00

  • Manganese modulates protein phosphorylation in the rat pancreas: in vitro evidence for cation selective regulation.

    abstract::The effects of manganese (Mn2+) on phosphorylation activity in the rat pancreas were examined in an in vitro phosphorylation assay and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of endogenous proteins. Several histones were phosphorylated in the presence of pancreatic supernatant obtained ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199009000-00015

    authors: Brockenbrough JS,Korc M

    更新日期:1990-09-01 00:00:00

  • Microvessel Density and Impact of Angiogenesis on Survival of Resected Pancreatic Cancer Patients: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...

    journal_title:Pancreas

    pub_type: 杂志文章,meta分析

    doi:10.1097/MPA.0000000000001237

    authors: Ntellas P,Dadouli K,Perivoliotis K,Sogka E,Pentheroudakis G,Ioannou M,Hadjichristodoulou C,Tepetes K,Mauri D

    更新日期:2019-02-01 00:00:00

  • Effects of dexamethasone on intercellular adhesion molecule 1 expression and inflammatory response in necrotizing acute pancreatitis in rats.

    abstract:OBJECTIVES:Adhesion molecules are involved in the inflammatory response during acute pancreatitis (AP). We investigated the effect of dexamethasone (Dx) on intercellular adhesion molecule 1 (ICAM-1) expression during AP and its consequences on leukocyte recruitment and pancreatic damage. METHODS:Acute pancreatitis was...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3181da0f3e

    authors: Ramudo L,Yubero S,Manso MA,Sanchez-Recio J,Weruaga E,De Dios I

    更新日期:2010-10-01 00:00:00

  • Effectiveness of discriminant analysis of serum CA 19-9 and elastase 1 in diagnosis of pancreatic carcinoma.

    abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-198908000-00002

    authors: Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

    更新日期:1989-01-01 00:00:00

  • Venous bypass grafting for celiac occlusion in radical pancreaticoduodenectomy.

    abstract::Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199105000-00014

    authors: Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

    更新日期:1991-05-01 00:00:00

  • Nonsurgical treatment of acute necrotizing pancreatitis.

    abstract::Our objective was to analyze conservative management in a large series of acute necrotizing pancreatitis (ANP) patients in a specialized center for pancreatic disease in the Internal Medicine and Emergency Department of a 1,500-bed hospital. One hundred ninety-nine patients with ANP were considered (mean age, 55.4 +/-...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199603000-00006

    authors: Uomo G,Visconti M,Manes G,Calise F,Laccetti M,Rabitti PG

    更新日期:1996-03-01 00:00:00

  • Long-term culture in matrigel enhances the insulin secretion of fetal porcine islet-like cell clusters in vitro.

    abstract::To study the influence of extracellular matrix (ECM) on isolated fetal porcine islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel (MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix for 20 days. The insulin accumulation in the culture medium was determined every fifth...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-200103000-00008

    authors: Oberg-Welsh C

    更新日期:2001-03-01 00:00:00

  • Deleterious effect of dithizone-DMSO staining on insulin secretion in rat and human pancreatic islets.

    abstract::Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/00006676-199403000-00003

    authors: Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

    更新日期:1994-03-01 00:00:00

  • Is a nonstented duct-to-mucosa anastomosis using the modified Kakita method a safe procedure?

    abstract:OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3181bd672c

    authors: Satoi S,Toyokawa H,Yanagimoto H,Yamamoto T,Hirooka S,Yui R,Yamaki S,Takahashi K,Matsui Y,Mergental H,Kwon AH

    更新日期:2010-03-01 00:00:00

  • A population-based study of severity in patients with acute on chronic pancreatitis.

    abstract:OBJECTIVES:The objectives of this study were to evaluate the severity of patients with acute pancreatitis (AP) on chronic pancreatitis (CP) and compare this to patients with AP without CP. METHODS:The Maryland Health Services database was queried for all adult inpatient discharges with a primary diagnosis of AP from 1...

    journal_title:Pancreas

    pub_type: 杂志文章

    doi:10.1097/MPA.0b013e3182a85af3

    authors: Akshintala VS,Hutfless SM,Yadav D,Khashab MA,Lennon AM,Makary MA,Hirose K,Andersen DK,Kalloo AN,Singh VK

    更新日期:2013-11-01 00:00:00