Abstract:
OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding without pancreatic stimulation, with particular reference to trypsin, because the avoidance of trypsin stimulation may optimize enteral feeding in acute pancreatitis. METHODS:The pancreatic secretory responses to feeding were studied in 36 healthy volunteers by standard double-lumen duodenal perfusion/aspiration techniques over 6 hours. Subjects were assigned to no feeding (n = 7), duodenal feeding with a polymeric diet (n = 7) or low-fat elemental diet (n = 6), mid-distal jejunal feeding (n = 11), or intravenous feeding (n = 5). All diets provided 40 kcal/kg ideal body weight/d and 1.5 g protein/kg ideal body weight/d. Plasma gut peptide responses were monitored in 15 subjects. RESULTS:In comparison with basal fasting trypsin secretion rates (mean = 134 [standard error = 22] U/h), duodenal feeding with the polymeric and elemental formulae stimulated trypsin secretion (mean = 408 [standard error = 51] U/h; P < 0.001), whereas intravenous feeding (mean = 171 [standard error = 34] U/h) and mid-distal jejunal (mean = 119 [standard error = 16] U/h) did not. Stimulation was associated with an increase in plasma cholecystokinin, whereas distal jejunal feeding resulted in an increase in plasma glucagon-like peptide-1 and peptide YY concentrations. CONCLUSIONS:Our results suggest that enteral feeding can be given without stimulating pancreatic trypsin secretion provided it is delivered into the mid-distal jejunum. The mechanism may involve activation of the ileal brake mechanism.
journal_name
Pancreasjournal_title
Pancreasauthors
Kaushik N,Pietraszewski M,Holst JJ,O'Keefe SJdoi
10.1097/01.mpa.0000183374.11919.e5subject
Has Abstractpub_date
2005-11-01 00:00:00pages
353-9issue
4eissn
0885-3177issn
1536-4828pii
00006676-200511000-00008journal_volume
31pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:The knowledge about pathogens and their antibiotic susceptibility patterns is essential to select an appropriate antibiotic. METHODS:We investigated the microbiological profile in pancreatic and extrapancreatic infections, and antibiotic sensitivity pattern in patients with acute pancreatitis. RESULTS:Of 5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001019
更新日期:2018-04-01 00:00:00
abstract::In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199205000-00016
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000150110.45017.fc
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:We investigated the relationship of pancreatic regenerating protein (reg) in models of acinar cell atrophy and aging, and the effect of reg I protein replacement on glucose tolerance. METHODS:Rats underwent pancreatic duct ligation (PDL) and were followed through 12 months. Aging rats were studied at 12 and...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31817f7893
更新日期:2008-11-01 00:00:00
abstract:INTRODUCTION:Severe acute pancreatitis (SAP) remains a serious disease state difficult to manage. Laparoscopic surgery represents a relatively new solution to this problem. This study was aimed to investigate the feasibility of laparoscopic treatment of SAP and the selection of laparoscopic procedures in various stages...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200310000-00019
更新日期:2003-10-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract::The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000202937.55460.0c
更新日期:2006-03-01 00:00:00
abstract::The present investigation provides follow-up data (up to 36 months) of exocrine and endocrine pancreatic function, inflammatory activity, pain, and body weight in 23 chronic pancreatitis patients submitted to Whipple's procedure plus intraoperative Ethibloc occlusion of the remaining pancreatic duct system between Jan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198711000-00016
更新日期:1987-01-01 00:00:00
abstract::Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199708000-00007
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000717
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e318150e557
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31823ba75a
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:Animal models are essential to understand the pathogenesis of acute pancreatitis (AP) and to develop new therapeutic strategies. Although it has been shown that cerulein-induced AP is associated with pain in experimental animals, most experiments are carried out without any pain-relieving treatment because r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000483
更新日期:2016-04-01 00:00:00
abstract::Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199501000-00007
更新日期:1995-01-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001505
更新日期:2020-03-01 00:00:00
abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199311000-00010
更新日期:1993-11-01 00:00:00
abstract::Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00016
更新日期:1992-01-01 00:00:00
abstract::Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00016
更新日期:1993-07-01 00:00:00
abstract::Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200007000-00049
更新日期:2000-07-01 00:00:00
abstract::In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199907000-00006
更新日期:1999-07-01 00:00:00
abstract::With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200003000-00007
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000060
更新日期:2014-04-01 00:00:00
abstract::The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervation was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholinesterase (AChE) activity and the induced fluor...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00013
更新日期:1987-01-01 00:00:00
abstract::A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00023
更新日期:1993-01-01 00:00:00
abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198908000-00002
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318205eb03
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:A selective therapy for pancreatitis is total pancreatectomy and islet autotransplantation. Outcomes and geographical variability of patients who had total pancreatectomy (TP) alone or total pancreatectomy with islet autotransplantation (TPIAT) were assessed. METHODS:Data were obtained from the Healthcare C...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001405
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00