Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array.

abstract：OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...

journal_title：Pancreas

authors： Dong X,Gao SL,Xie QP,Xu L,Xu YL,Wu YL

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Invasion and metastasis of pancreatic cancer (PC) require cell motility and adhesion, which depend on the activity of cytoskeleton. A cytoskeletal component indispensable for these processes is myosin II, the cytoplasmic analogue of smooth and skeletal muscle myosin. AIMS AND METHODOLOGY:Because the activ...

journal_title：Pancreas

authors： Kaneko K,Satoh K,Masamune A,Satoh A,Shimosegawa T

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...

journal_title：Pancreas

authors： Wang Y,Qi M,McGarrigle JJ,Xing Y,Mendoza-Elias JE,Bochenek M,Marchese E,He Y,Oberholzer J

更新日期：2020-05-01 00:00:00

abstract：:Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...

journal_title：Pancreas

authors： Yao CZ,Poston GJ,Ishizuka J,Townsend CM Jr,Thompson JC

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...

journal_title：Pancreas

authors： Muehling B,Kolb A,Ramadani M,Schmidt E,Gansauge F,Beger HG

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...

journal_title：Pancreas

authors： Gardner TB,Taylor DJ,Gordon SR

更新日期：2014-01-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:To provide histologic correlation of endoscopic ultrasound (EUS) findings believed to represent chronic pancreatitis (CP). METHODS:Eighteen postmortem pancreatic specimens in patients dying of all causes were examined in vitro by EUS for features of CP: (1) echogenic foci, (2) hypoechoic foci, (3) echogenic...

journal_title：Pancreas

authors： Bhutani MS,Arantes VN,Verma D,Moezzi J,Suryaprasad S,Kapadia AS,Gopalswamy N

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...

journal_title：Pancreas

authors： Nishida A,Inatomi O,Fujimoto T,Imaeda H,Tani M,Andoh A

更新日期：2017-04-01 00:00:00

abstract：:Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...

journal_title：Pancreas

authors： Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

更新日期：1994-03-01 00:00:00

abstract：:Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcin...

journal_title：Pancreas

authors： Yong WH,Southern JF,Pins MR,Warshaw AL,Compton CC,Lewandrowski KB

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：:Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...

journal_title：Pancreas

authors： Lukás Z,Dvorák K,Kroupová I,Valásková I,Habanec B

更新日期：2006-04-01 00:00:00

abstract：:Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....

journal_title：Pancreas

authors： Thosani N,Dasari CS,Bhutani MS,Raimondo M,Guha S

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this s...

journal_title：Pancreas

authors： Coté GA,Durkalski-Mauldin VL,Serrano J,Klintworth E,Williams AW,Cruz-Monserrate Z,Arain M,Buxbaum JL,Conwell DL,Fogel EL,Freeman ML,Gardner TB,van Geenen E,Groce JR,Jonnalagadda SS,Keswani RN,Menon S,Moffatt DC,Papach

更新日期：2019-09-01 00:00:00

abstract：:We have studied the degree of pancreatic secretory alterations assessed by secretin-cerulein test (S-C) in relation to various morphological changes detected by real-time ultrasonography (US) in 42 patients affected by chronic pancreatitis. Exocrine insufficiency was found in 41 patients (97.6%), while morphological a...

journal_title：Pancreas

authors： Bolondi L,Priori P,Gullo L,Santi V,Li Bassi S,Barbara L,Labó G

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...

journal_title：Pancreas

authors： Rosenblum RE,Harris CK,Baeg KJ,Starr JA,Brais LK,Stashek KM,Ward SC,Katona BW,Clancy TE,Wisnivesky JP,Kulke MH,Metz DC,Kim MK,Chan JA

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...

journal_title：Pancreas

authors： Zhang X,Duan W,Lee WN,Zhang Y,Xiang F,Liu Q,Go VL,Xiao GG

更新日期：2016-08-01 00:00:00

abstract：:beta-1,4-Galactosyltransferase (GalTase) is the glycosyltransferase in the Golgi apparatus that transfers galactose from UDP-galactose to terminal N-acetylglucosamine residues in glycoconjugates with formation of a beta-1,4 linkage. Neoplasms undergo various changes in the carbohydrate moieties of their glycoconjugate...

journal_title：Pancreas

authors： Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H

更新日期：1999-08-01 00:00:00

abstract：:It was reported that free fatty acids degraded from triglycerides by lipase may play a major role in acute necrotizing or hyperlipidemia-induced pancreatitis. We hypothesized that this injury may be related to the peroxidation of cell membrane phospholipids and tested this hypothesis using isolated pancreatic acini. P...

journal_title：Pancreas

authors： Morita Y,Yoshikawa T,Takeda S,Matsuyama K,Takahashi S,Yoshida N,Clemens MG,Kondo M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:Acute pancreatic duct obstruction causes hyperamylasemia and mild pancreatic inflammation. We hypothesized that bile exclusion from the gut, which stimulates pancreatic secretion, exacerbates acute pancreatitis caused by pancreatic duct obstruction. Rats were surgically prepared with gastric, duodenal, bile, and pancr...

journal_title：Pancreas

authors： Murayama KM,Drew JB,Yokoo H,Joehl RJ

更新日期：1991-03-01 00:00:00

abstract：INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...

journal_title：Pancreas

authors： Reeve JR Jr,McVey DC,Bunnett NW,Solomon TE,Keire DA,Ho FJ,Davis MT,Lee TD,Shively JE,Vigna SR

更新日期：2002-10-01 00:00:00

abstract：:Stimulation of intact rat pancreatic acini with cholecystokinin (CCK) enhances the phosphorylation of the ribosomal protein S6 in a dose-dependent manner with half maximal stimulation at 40 pM and maximal stimulation at 1 nM CCK octapeptide. Soluble cellular extracts contained S6 kinase activity assayed using purified...

journal_title：Pancreas

authors： Sung CK,Williams JA

更新日期：1990-11-01 00:00:00

abstract：:The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...

journal_title：Pancreas

authors： Massoumi RL,Hines OJ,Eibl G,King JC

更新日期：2019-01-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:We recently established a method of isolation and primary monolayer culture of porcine pancreatic endocrine cells that involves the use of nicotinamide. AIM:To obtain genetic information on cultured porcine endocrine cells and to examine cell function in relation to insulin secretion during long-term cult...

journal_title：Pancreas

authors： Tsuchiya M,Tsuchiya K,Iwami Y,Ohgawara H

更新日期：2003-01-01 00:00:00

abstract：:A 50-year-old female was referred to our hospital because of postprandial epigastric pain and pancreatic head mass. On admission, an elastic hard mass with tenderness was palpable in the epigastric region. Laboratory findings showed no abnormalities, except for a slightly elevated C-reactive protein value and iron def...

journal_title：Pancreas

authors： Taguchi M,Nishikawa S,Matsuoka H,Narita R,Abe S,Fukuda K,Miyamoto H,Taniguchi H,Otsuki M

更新日期：2006-11-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...

journal_title：Pancreas

authors： Kiehne K,Herzig KH,Fölsch UR

更新日期：1997-07-01 00:00:00