Relationship between morphological changes detected by ultrasonography and pancreatic exocrine function in chronic pancreatitis.

abstract：:Previous studies have shown that the DU-PAN-2 antigen is elevated in approximately 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (less than 400 U/ml) in 99% of normal subjects. In this study, the DU-PAN-2 antigen level of the serum and pancreatic ductal fluid in pat...

journal_title：Pancreas

authors： Mahvi DM,Seigler HF,Meyers WC,Kalthoff H,Schmiegel WH,Metzgar RS

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

journal_title：Pancreas

authors： Shah P,Singh MH,Yang YX,Metz DC

更新日期：2013-08-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...

journal_title：Pancreas

authors： Hirono S,Kawai M,Okada KI,Miyazawa M,Shimizu A,Kitahata Y,Ueno M,Yamaue H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Porcine islets are the most suitable for xeno-islet transplantation. However, it is necessary to establish an effective preservation method against its fragility. Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of ...

journal_title：Pancreas

authors： Ikemoto T,Noguchi H,Fujita Y,Takita M,Shimoda M,Sugimoto K,Jackson A,Naziruddin B,Shimada M,Levy MF,Matsumoto S

更新日期：2010-10-01 00:00:00

abstract：:Utilizing scanning electron microscopy and isolated, vascularly perfused rat pancreas, we studied the angioarchitecture and the effect of the insulinotropic hormone, gastric inhibitory polypeptide (GIP), on cholecystokinin (CCK)-stimulated exocrine secretion. We tried to correlate the microcirculation with the physiol...

journal_title：Pancreas

authors： Mueller MK,Scheck T,Dreesmann V,Miodonski A,Goebell H

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...

journal_title：Pancreas

authors： Morishita K,Shimizu K,Haruta I,Kawamura S,Kobayashi M,Shiratori K

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...

journal_title：Pancreas

authors： Toomey DP,Manahan E,McKeown C,Rogers A,McMillan H,Geary M,Conlon KC,Murphy JF

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...

journal_title：Pancreas

authors： Jelski W,Chrostek L,Szmitkowski M

更新日期：2007-08-01 00:00:00

abstract：:Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...

journal_title：Pancreas

authors： Nakano S,Tachibana I,Otsuki M

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...

journal_title：Pancreas

authors： Gangi A,Malafa M,Klapman J

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...

journal_title：Pancreas

authors： Yasuda T,Ueda T,Takeyama Y,Shinzeki M,Sawa H,Nakajima T,Ajiki T,Fujino Y,Suzuki Y,Kuroda Y

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Protein kinase C (PKC) is involved in cell growth, differentiation, and apoptosis. We investigated the effects of the PKC activator, the tetradecanylphorbol acetate (TPA), in human pancreatic cancer cells. METHODS:Cell proliferation was measured by thymidine incorporation. Expression of cell cycle proteins ...

journal_title：Pancreas

authors： Salabat MR,Ding XZ,Flesche JB,Ujiki MB,Robin TP,Talamonti MS,Bell RH Jr,Adrian TE

更新日期：2006-08-01 00:00:00

abstract：:Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...

journal_title：Pancreas

authors： Joly I,David A,Payan MJ,Sahel J,Sarles H

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:The present study describes a simple and cost-effective islet isolation procedure. Using this method, allogeneic islets reverse diabetes in cynomolgus monkeys. METHODS:Pancreatic tissue from 11 cynomolgus monkeys were digested, collected, and purified using a simplified method. Islet quantification, purity,...

journal_title：Pancreas

authors： Qi M,Wang Y,Formo K,Marchese E,Wang S,McGarrigle JJ,Bochenek MA,Kinzer K,Vaca P,Davis M,Ahn SJ,Chang K,Bartholomew A,Benedetti E,Oberholzer J

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Pancreatic ductal adenocarcinoma remains as a chemoresistant disease with the poorest prognosis. Gemcitabine has been the standard treatment during the last decade. Erlotinib, a tyrosine kinase inhibitor, in combination with gemcitabine produces a small increase in survival. However, these results remain ins...

journal_title：Pancreas

authors： Torres C,Linares A,Alejandre MJ,Palomino-Morales RJ,Delgado JR,Perales S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...

journal_title：Pancreas

authors： Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:The objectives of the study were to compare endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in the etiological diagnosis of patients initially diagnosed with idiopathic acute pancreatitis and to determine the clinical and analytical factors related to the end result of...

journal_title：Pancreas

authors： Ortega AR,Gómez-Rodríguez R,Romero M,Fernández-Zapardiel S,Céspedes Mdel M,Carrobles JM

更新日期：2011-03-01 00:00:00

abstract：:It has been suggested that the severity of an attack of acute pancreatitis is related to the presence of intraglandular trypsinogen activation and that disease severity is also reflected by the degree of the acute-phase protein response. In this study we examine the relationships among amylase release, the degree of t...

journal_title：Pancreas

authors： Heath DI,Cruickshank A,Gudgeon AM,Jehanli A,Shenkin A,Imrie CW

更新日期：1995-05-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:Scanning electron microscopy (SEM) and energy dispersive x-ray fluorescence (EDXRF) have been used in this study to investigate the morphology, nature, and arrangement of major, minor, and trace elements in human pancreatic calculi (PC) obtained from patients with alcoholic and tropical pancreatitis. The present study...

journal_title：Pancreas

authors： Pitchumoni CS,Viswanathan KV,Gee Varghese PJ,Banks PA

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with an established role in the treatment of cutaneous and liver tumors. This study was designed...

journal_title：Pancreas

authors： Dežman R,Čemažar M,Serša G,Seliškar A,Erjavec V,Trotovšek B,Gašljevič G,Bošnjak M,Lampreht Tratar U,Kos B,Djokić M,Milevoj N,Štukelj M,Boc N,Izlakar J,Popovič P

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...

journal_title：Pancreas

authors： Law JK,Ahmed A,Singh VK,Akshintala VS,Olson MT,Raman SP,Ali SZ,Fishman EK,Kamel I,Canto MI,Dal Molin M,Moran RA,Khashab MA,Ahuja N,Goggins M,Hruban RH,Wolfgang CL,Lennon AM

更新日期：2014-04-01 00:00:00

abstract：:Cutaneous metastasis of an occult malignancy to the umbilicus has come to be known as a Sister Mary Joseph's nodule (SMJN). More than 400 cases of this well-described clinical presentation of advanced gastrointestinal and gynecologic cancers have been reported. Pancreatic cancer presenting as a SMJN is a rare phenomen...

journal_title：Pancreas

authors： Yendluri V,Centeno B,Springett GM

更新日期：2007-01-01 00:00:00

abstract：:With a nitrosamine induced hamster pancreatic cancer cell line (HaP-T1), survival time and metastatic rates were compared between orthotopic cell implantation (OCI; n = 5) and orthotopic tissue implantation (OTI; n = 5) models. All the tumors were palpable (100% tumor take) after 1 week in both groups. Hamsters in the...

journal_title：Pancreas

authors： Morioka CY,Saito S,Ohzawa K,Watanabe A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to assess the prognostic significance of late parenchymal pancreas necrosis as observed on serial contrast-enhanced computed tomographic (CT) scan. METHODS:Eighty-four patients with acute necrotizing pancreatitis were included. All initial CT scans were examined on complete contr...

journal_title：Pancreas

authors： Wijffels NA,van Walraven LA,Ophof PJ,Hop WC,van der Harst E,Lange JF

更新日期：2007-03-01 00:00:00

abstract：:Solid pseudopapillary tumor of the pancreas is a rare neoplasm with low malignant potential, which affects predominantly young females. Only approximately 10% to 15% cases of solid pseudopapillary tumors (SPTs) are malignant. We present the case of a 57-year-old woman who developed malignant SPT of the pancreas. Meanw...

journal_title：Pancreas

authors： Ji S,Xu J,Zhang B,Xu Y,Liu C,Long J,Ni Q,Yu X

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this s...

journal_title：Pancreas

authors： Coté GA,Durkalski-Mauldin VL,Serrano J,Klintworth E,Williams AW,Cruz-Monserrate Z,Arain M,Buxbaum JL,Conwell DL,Fogel EL,Freeman ML,Gardner TB,van Geenen E,Groce JR,Jonnalagadda SS,Keswani RN,Menon S,Moffatt DC,Papach

更新日期：2019-09-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...

journal_title：Pancreas

authors： Blanchard LM,Paquette B,Larose L,Morisset J

更新日期：1990-01-01 00:00:00